Production of HIV-1-based virus-like particles for vaccination: achievements and limits

The Incorporation of Host Proteins into the External HIV-1 Envelope

(2019) Jonathan Burnie et al.   Viruses-Basel

Enhancement of HIV-1 VLP production using gene inhibition strategies

(2018) Javier Fuenmayor et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The NC domain of HIV-1 Gag contributes to the interaction of Gag with TSG101

(2018) Salah Edin El Meshri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Extended gene expression for Gag VLP production achieved at bioreactor scale

(2018) Javier Fuenmayor et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Intrastructural Help: Harnessing T Helper Cells Induced by Licensed Vaccines for Improvement of HIV Env Antibody Responses to Virus-Like Particle Vaccines

(2018) Hassan Elsayed et al.   JOURNAL OF VIROLOGY

A heterogeneous human immunodeficiency virus-like particle (VLP) formulation produced by a novel vector system

(2018) Joshua Pankrac et al.   npj Vaccines

Guiding the humoral response against HIV-1 toward a MPER adjacent region by immunization with a VLP-formulated antibody-selected envelope variant

(2018) Carolina Beltran-Pavez et al.   PLoS One

Immunogenicity and efficacy of DNA/MVA HIV vaccines in rhesus macaque models

(2017) Lynette Siv Chea et al.   Expert Review of Vaccines

Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development

(2017) Mattia Bonsignori et al.   IMMUNOLOGICAL REVIEWS

Production of HIV virus-like particles by transient transfection of CAP-T cells at bioreactor scale avoiding medium replacement

(2017) Sonia Gutiérrez-Granados et al.   JOURNAL OF BIOTECHNOLOGY

Separation of HIV-1 gag virus-like particles from vesicular particles impurities by hydroxyl-functionalized monoliths

(2017) Petra Steppert et al.   JOURNAL OF SEPARATION SCIENCE

Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike

(2017) Gabriel Ozorowski et al.   NATURE

Process intensification for high yield production of influenza H1N1 Gag virus-like particles using an inducible HEK-293 stable cell line

(2017) Alina Venereo-Sanchez et al.   VACCINE

Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction

(2017) Ema T. Crooks et al.   VIROLOGY

Membrane-anchored CCL20 augments HIV Env-specific mucosal immune responses

(2017) Xianliang Sun et al.   Virology Journal

Particle-based delivery of the HIV envelope protein

(2017) Benedikt Asbach et al.   Current Opinion in HIV and AIDS

A novel HIV vaccine targeting the protease cleavage sites

(2017) Hongzhao Li et al.   AIDS Research and Therapy

Gene overlapping and size constraints in the viral world

(2016) Nadav Brandes et al.   Biology Direct

Clarification of vaccines: An overview of filter based technology trends and best practices

(2016) Lise Besnard et al.   BIOTECHNOLOGY ADVANCES

Retroviral particles are effectively purified on an affinity matrix containing peptides selected by phage-display

(2016) Cláudia S. M. Fernandes et al.   Biotechnology Journal

Functional Segregation of Overlapping Genes in HIV

(2016) Jason D. Fernandes et al.   CELL

Purification of HIV-1 gag virus-like particles and separation of other extracellular particles

(2016) Petra Steppert et al.   JOURNAL OF CHROMATOGRAPHY A

Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques

(2016) Smita S. Iyer et al.   JOURNAL OF VIROLOGY

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

(2016) Sudhir Pai Kasturi et al.   JOURNAL OF VIROLOGY

Hemagglutinin and neuraminidase containing virus-like particles produced in HEK-293 suspension culture: An effective influenza vaccine candidate

(2016) Alina Venereo-Sanchez et al.   VACCINE

Adventitious agents and live viral vectored vaccines: Considerations for archiving samples of biological materials for retrospective analysis

(2016) Bettina Klug et al.   VACCINE

Toll-like receptor 3 adjuvant in combination with virus-like particles elicit a humoral response against HIV

(2016) Ethan Poteet et al.   VACCINE

Effects of modification of the HIV-1 Env cytoplasmic tail on immunogenicity of VLP vaccines

(2016) Andrei N. Vzorov et al.   VIROLOGY

Retroviral particles are effectively purified on an affinity matrix containing peptides selected by phage-display

(2016) Cláudia S. M. Fernandes et al.   Biotechnology Journal

Production of lentiviral vectors

(2016) Otto-Wilhelm Merten et al.   Molecular Therapy-Methods & Clinical Development

Immunological Characterization of Plant-Based HIV-1 Gag/Dgp41 Virus-Like Particles

(2016) Sarah A. Kessans et al.   PLoS One

Selection and optimization of transfection enhancer additives for increased virus-like particle production in HEK293 suspension cell cultures

(2015) Laura Cervera et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Optimized production of HIV-1 virus-like particles by transient transfection in CAP-T cells

(2015) Sonia Gutiérrez-Granados et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Extended gene expression by medium exchange and repeated transient transfection for recombinant protein production enhancement

(2015) Laura Cervera et al.   BIOTECHNOLOGY AND BIOENGINEERING

Improved virus purification processes for vaccines and gene therapy

(2015) Piergiuseppe Nestola et al.   BIOTECHNOLOGY AND BIOENGINEERING

HIV-1 Integration Landscape during Latent and Active Infection

(2015) Lillian B. Cohn et al.   CELL

Sizing the optimal dimensions of a vaccine delivery system: a particulate matter

(2015) Bram Slütter et al.   Expert Opinion on Drug Delivery

Bottlenecks in HIV-1 transmission: insights from the study of founder viruses

(2015) Sarah B. Joseph et al.   NATURE REVIEWS MICROBIOLOGY

ISCOMATRIX™ adjuvant promotes epitope spreading and antibody affinity maturation of influenza A H7N9 virus like particle vaccine that correlate with virus neutralization in humans

(2015) Ka Yan Chung et al.   VACCINE

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

(2015) Ema T. Crooks et al.   PLoS Pathogens

A Polyvalent Clade B Virus-Like Particle HIV Vaccine Combined with Partially Protective Oral Preexposure Prophylaxis Prevents Simian–Human Immunodeficiency Virus Infection in Macaques and Primes for Virus-Amplified Immunity

(2014) Ted M. Ross et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Optimised concentration and purification of retroviruses using membrane chromatography

(2014) D.J. McNally et al.   JOURNAL OF CHROMATOGRAPHY A

Basic Motifs Target PSGL-1, CD43, and CD44 to Plasma Membrane Sites Where HIV-1 Assembles

(2014) Jonathan R. Grover et al.   JOURNAL OF VIROLOGY

A Temporospatial Map That Defines Specific Steps at Which Critical Surfaces in the Gag MA and CA Domains Act during Immature HIV-1 Capsid Assembly in Cells

(2014) B. A. Robinson et al.   JOURNAL OF VIROLOGY

HIV-1 Uncoating Is Facilitated by Dynein and Kinesin 1

(2014) Z. Lukic et al.   JOURNAL OF VIROLOGY

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

Novel vaccine vectors for HIV-1

(2014) Dan H. Barouch et al.   NATURE REVIEWS MICROBIOLOGY

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

(2014) Erik Serrao et al.   NUCLEIC ACIDS RESEARCH

Long-Term Follow-up Observation of the Safety, Immunogenicity, and Effectiveness of Gardasil™ in Adult Women

(2014) Joaquin Luna et al.   PLoS One

ALIX Is Recruited Temporarily into HIV-1 Budding Sites at the End of Gag Assembly

(2014) Pei-I Ku et al.   PLoS One

Generation of a Recombinant Gag Virus-Like-Particle Panel for the Evaluation of p24 Antigen Detection by Diagnostic HIV Tests

(2014) Beatrice N. Vetter et al.   PLoS One

Multi-parameter exploration of HIV-1 virus-like particles as neutralizing antibody immunogens in guinea pigs, rabbits and macaques

(2014) Tommy Tong et al.   VIROLOGY

Structure of cellular ESCRT-III spirals and their relationship to HIV budding

(2014) Anil G Cashikar et al.   eLife

The High Cost of Fidelity

(2013) Sarah B. Lloyd et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Bioengineering virus-like particles as vaccines

(2013) Linda H.L. Lua et al.   BIOTECHNOLOGY AND BIOENGINEERING

Generation of HIV-1 Gag VLPs by transient transfection of HEK 293 suspension cell cultures using an optimized animal-derived component free medium

(2013) Laura Cervera et al.   JOURNAL OF BIOTECHNOLOGY

The Conserved Set of Host Proteins Incorporated into HIV-1 Virions Suggests a Common Egress Pathway in Multiple Cell Types

(2013) Michael E. Linde et al.   JOURNAL OF PROTEOME RESEARCH

Use of hollow fiber tangential flow filtration for the recovery and concentration of HIV virus-like particles produced in insect cells

(2013) Alejandro Negrete et al.   JOURNAL OF VIROLOGICAL METHODS

Robust Immunity to an Auxotrophic Mycobacterium bovis BCG-VLP Prime-Boost HIV Vaccine Candidate in a Nonhuman Primate Model

(2013) G. K. Chege et al.   JOURNAL OF VIROLOGY

Biological and biochemical characterization of HIV-1 Gag/dgp41 virus-like particles expressed inNicotiana benthamiana

(2013) Sarah A. Kessans et al.   PLANT BIOTECHNOLOGY JOURNAL

GagPol-specific CD4+ T-cells increase the antibody response to Env by intrastructural help

(2013) Ghulam Nabi et al.   Retrovirology

Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway

(2013) W. M. Henne et al.   Cold Spring Harbor Perspectives in Biology

HIV-1 Assembly, Budding, and Maturation

(2013) W. I. Sundquist et al.   Cold Spring Harbor Perspectives in Medicine

How to get out: ssRNA enveloped viruses and membrane fission

(2013) Winfried Weissenhorn et al.   Current Opinion in Virology

State-of-the-art in downstream processing of monoclonal antibodies: Process trends in design and validation

(2012) P. A. Marichal-Gallardo et al.   BIOTECHNOLOGY PROGRESS

The molecular basis of HIV entry

(2012) Per Johan Klasse   CELLULAR MICROBIOLOGY

Immunogenicity of HIV Virus-Like Particles in Rhesus Macaques by Intranasal Administration

(2012) Luigi Buonaguro et al.   Clinical and Vaccine Immunology

HIV-1 Virus-Like Particles Produced by Stably Transfected Drosophila S2 Cells: a Desirable Vaccine Component

(2012) L. Yang et al.   JOURNAL OF VIROLOGY

Construction and Characterization of Virus-Like Particles: A Review

(2012) Andris Zeltins   MOLECULAR BIOTECHNOLOGY

Targeting Antibody Responses to the Membrane Proximal External Region of the Envelope Glycoprotein of Human Immunodeficiency Virus

(2012) Donatien Kamdem Toukam et al.   PLoS One

A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

(2012) Stefanie Dietmair et al.   PLoS One

Human Immunodeficiency Virus gag and protease: partners in resistance

(2012) Axel Fun et al.   Retrovirology

Stability studies of HIV-1 Pr55gag virus-like particles made in insect cells after storage in various formulation media

(2012) Alisson Lynch et al.   Virology Journal

Elements in HIV-1 Gag contributing to virus particle assembly

(2012) Ina P. O’Carroll et al.   VIRUS RESEARCH

Plant-derived virus-like particles as vaccines

(2012) Qiang Chen et al.   Human Vaccines & Immunotherapeutics

Pathogenic Mechanisms of HIV Disease

(2011) Susan Moir et al.   Annual Review of Pathology-Mechanisms of Disease

Rational design and optimization of downstream processes of virus particles for biopharmaceutical applications: Current advances

(2011) Tiago Vicente et al.   BIOTECHNOLOGY ADVANCES

Mammalian cell protein expression for biopharmaceutical production

(2011) Jianwei Zhu   BIOTECHNOLOGY ADVANCES

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Virus‑like particles as a vaccine delivery system: Myths and facts

(2011) Polly Roy et al.   Human vaccines & immunotherapeutics

Large-scale production and purification of VLP-based vaccines

(2011) Tiago Vicente et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

HIV-1 Envelope Glycoprotein Biosynthesis, Trafficking, and Incorporation

(2011) Mary Ann Checkley et al.   JOURNAL OF MOLECULAR BIOLOGY

The Molecular Architecture of HIV

(2011) John A.G. Briggs et al.   JOURNAL OF MOLECULAR BIOLOGY

Induction of HIV Neutralizing Antibodies against the MPER of the HIV Envelope Protein by HA/gp41 Chimeric Protein-Based DNA and VLP Vaccines

(2011) Ling Ye et al.   PLoS One

CCL28 Induces Mucosal Homing of HIV-1-Specific IgA-Secreting Plasma Cells in Mice Immunized with HIV-1 Virus-Like Particles

(2011) Veronica Rainone et al.   PLoS One

Features, processing states, and heterologous protein interactions in the modulation of the retroviral nucleocapsid protein function

(2011) Gilles Mirambeau et al.   RNA Biology

HIV-Gag VLPs presenting trimeric HIV-1 gp140 spikes constitutively expressed in stable double transfected insect cell line

(2011) M. Tagliamonte et al.   VACCINE

Generation of representative primary virus isolates from blood plasma after isolation of HIV-1 with CD44 MicroBeads

(2010) Marion Cornelissen et al.   ARCHIVES OF VIROLOGY

Use of the piggyBac transposon to create HIV-1 gag transgenic insect cell lines for continuous VLP production

(2010) Alisson G Lynch et al.   BMC BIOTECHNOLOGY

Exosomes and retroviruses: the chicken or the egg?

(2010) Nuria Izquierdo-Useros et al.   CELLULAR MICROBIOLOGY

Virus-like particles in vaccine development

(2010) António Roldão et al.   Expert Review of Vaccines

Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication

(2010) M. E. Abram et al.   JOURNAL OF VIROLOGY

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

(2010) Thomas Wollert et al.   NATURE

Membrane budding and scission by the ESCRT machinery: it's all in the neck

(2010) James H. Hurley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Divergent pathways lead to ESCRT-III-catalyzed membrane fission

(2010) Suman Peel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Constitutive expression of HIV-VLPs in stably transfected insect cell line for efficient delivery system

(2010) M. Tagliamonte et al.   VACCINE

Optimization of chimeric HIV-1 virus-like particle production in a baculovirus-insect cell expression system

(2009) Sirika Pillay et al.   BIOTECHNOLOGY PROGRESS

The Cell Biology of HIV-1 Virion Genesis

(2009) Paul D. Bieniasz   Cell Host & Microbe

Divergent Bro1 Domains Share the Capacity To Bind Human Immunodeficiency Virus Type 1 Nucleocapsid and To Enhance Virus-Like Particle Production

(2009) S. Popov et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

(2009) M. D. Simek et al.   JOURNAL OF VIROLOGY

Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women

(2009) J Paavonen et al.   LANCET

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-level expression of the HIV-1 Pr55gag polyprotein in transgenic tobacco chloroplasts

(2009) Nunzia Scotti et al.   PLANTA

Structure and assembly of immature HIV

(2009) J. A. G. Briggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient and reproducible generation of high-expressing, stable human cell lines without need for antibiotic selection

(2008) Gudrun Schiedner et al.   BMC BIOTECHNOLOGY

Expression of HIV-1 antigens in plants as potential subunit vaccines

(2008) Ann Meyers et al.   BMC BIOTECHNOLOGY

Effect of particle ingestion on the fouling reduction and heat transfer enhancement of a No-Distributor-Fluidized heat exchanger

(2008) Yongdu Jun et al.   Journal of Mechanical Science and Technology

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET