State-of-the-art in downstream processing of monoclonal antibodies: Process trends in design and validation

Analysis of host-cell proteins in biotherapeutic proteins by comprehensive online two-dimensional liquid chromatography/mass spectrometry

(2012) Catalin Doneanu et al.   mAbs

Cation exchange chromatography provides effective retrovirus clearance for antibody purification processes

(2011) Lisa Connell-Crowley et al.   BIOTECHNOLOGY AND BIOENGINEERING

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line

(2011) A.S. Tait et al.   BIOTECHNOLOGY AND BIOENGINEERING

Aggregates in monoclonal antibody manufacturing processes

(2011) María Vázquez-Rey et al.   BIOTECHNOLOGY AND BIOENGINEERING

Process and economic evaluation for monoclonal antibody purification using a membrane-only process

(2011) Hemanthram Varadaraju et al.   BIOTECHNOLOGY PROGRESS

The freezing step in lyophilization: Physico-chemical fundamentals, freezing methods and consequences on process performance and quality attributes of biopharmaceuticals

(2011) Julia Christina Kasper et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Photosensitizers Form in Histidine Buffer and Mediate the Photodegradation of a Monoclonal Antibody

(2011) Steven D. Stroop et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Fragmentation of monoclonal antibodies

(2011) Josef Vlasak et al.   mAbs

Advances in the production and downstream processing of antibodies

(2011) John H. Chon et al.   New Biotechnology

Theoretical and Experimental Analysis of Anti-A Antibody Capture in Novel Integrated Bead and Hollow Fiber Modules

(2010) Azadeh Alikhani et al.   ANNALS OF BIOMEDICAL ENGINEERING

Recovery and purification process development for monoclonal antibody production

(2010) Hui F. Liu et al.   mAbs

Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry

(2010) William Burkitt et al.   PROTEIN SCIENCE

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Host cell proteins in biologics development: Identification, quantitation and risk assessment

(2009) Xing Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Aggregation of a monoclonal antibody induced by adsorption to stainless steel

(2009) Jared S. Bee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development

(2009) Mi Jin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Virus filtration of high-concentration monoclonal antibody solutions

(2009) Bruno F. Marques et al.   BIOTECHNOLOGY PROGRESS

Refolding of scFv mini-antibodies using size-exclusion chromatography via arginine solution layer

(2009) K.K. Fursova et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Ultrafiltration concentration of monoclonal antibody solutions: Development of an optimized method minimizing aggregation

(2009) E. Rosenberg et al.   JOURNAL OF MEMBRANE SCIENCE

Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear

(2009) Thomas W. Patapoff et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

2-D DIGE to expedite downstream process development for human monoclonal antibody purification

(2009) Julita K. Grzeskowiak et al.   PROTEIN EXPRESSION AND PURIFICATION

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

(2009) Hai Pan et al.   PROTEIN SCIENCE

Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody

(2009) Sandipan Sinha et al.   PROTEIN SCIENCE

Efficient production of active form of recombinant cassava hydroxynitrile lyase using Escherichia coli in low-temperature culture

(2008) Hisashi Semba et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Viral clearance using disposable systems in monoclonal antibody commercial downstream processing

(2008) Joe X. Zhou et al.   BIOTECHNOLOGY AND BIOENGINEERING

Anion exchange chromatography provides a robust, predictable process to ensure viral safety of biotechnology products

(2008) Daniel M. Strauss et al.   BIOTECHNOLOGY AND BIOENGINEERING

Advances in Primary Recovery: Centrifugation and Membrane Technology

(2008) D.J. Roush et al.   BIOTECHNOLOGY PROGRESS

Demonstration of Robust Host Cell Protein Clearance in Biopharmaceutical Downstream Processes

(2008) A.A. Shukla et al.   BIOTECHNOLOGY PROGRESS

Bioseparation in Antibody Manufacturing: The Good, The Bad and The Ugly

(2008) U. Gottschalk   BIOTECHNOLOGY PROGRESS

Host cell protein clearance during protein a chromatography: Development of an improved column wash step

(2008) Abhinav A. Shukla et al.   BIOTECHNOLOGY PROGRESS

Monoclonal Antibodies as Innovative Therapeutics

(2008) Janice Reichert   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Robustness of virus removal by protein A chromatography is independent of media lifetime

(2008) Scott Lute et al.   JOURNAL OF CHROMATOGRAPHY A

Downstream processing of human antibodies integrating an extraction capture step and cation exchange chromatography

(2008) Ana M. Azevedo et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Fragmentation of a Recombinant Monoclonal Antibody at Various pH

(2008) Georgeen Gaza-Bulseco et al.   PHARMACEUTICAL RESEARCH