Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

(2019) Christopher R. M. Asquith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK)

(2019) Christopher R.M. Asquith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective blockage of Serratia marcescens ShlA by nickel inhibits the pore forming toxin‐mediated phenotypes in eukaryotic cells

(2019) Martina Lazzaro et al.   CELLULAR MICROBIOLOGY

Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma

(2019) Christopher R. M. Asquith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections

(2018) Matthew B Calvert et al.   Beilstein Journal of Organic Chemistry

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

(2017) Seth W. Dickey et al.   NATURE REVIEWS DRUG DISCOVERY

The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases

(2016) Thibaut Boibessot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inactivation of Multiple Bacterial Histidine Kinases by Targeting the ATP-Binding Domain

(2015) Kaelyn E. Wilke et al.   ACS Chemical Biology

Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens

(2015) Christopher N. LaRock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Bacterial Nucleoid-Associated Protein Uncouples Transcription Levels from Transcription Timing

(2014) I. Zwir et al.   mBio

Bacterial Mg2+Homeostasis, Transport, and Virulence

(2013) Eduardo A. Groisman et al.   Annual Review of Genetics

Unsaturated Long Chain Free Fatty Acids Are Input Signals of theSalmonella entericaPhoP/PhoQ Regulatory System

(2013) Gastón Viarengo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Thin-layer Chromatography Autographic Method for the Detection of Inhibitors of theSalmonellaPhoP-PhoQ Regulatory System

(2013) Mario O. Salazar et al.   PHYTOCHEMICAL ANALYSIS

Identifying promoter features of co-regulated genes with similar network motifs

(2012) Oscar Harari et al.   BMC BIOINFORMATICS

Genome Expression Analysis of Nonproliferating Intracellular Salmonella enterica Serovar Typhimurium Unravels an Acid pH-Dependent PhoP-PhoQ Response Essential for Dormancy

(2012) Cristina Núñez-Hernández et al.   INFECTION AND IMMUNITY

Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa

(2012) Nicholas A Feasey et al.   LANCET

Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors

(2012) R. Figueira et al.   MICROBIOLOGY-SGM

The promoter architectural landscape of the Salmonella PhoP regulon

(2012) Igor Zwir et al.   MOLECULAR MICROBIOLOGY

Contribution of the PhoP/Q regulon to survival and replication of Salmonella enterica serovar Typhimurium in macrophages

(2011) J. A. Thompson et al.   MICROBIOLOGY-SGM

The Global Burden of NontyphoidalSalmonellaGastroenteritis

(2010) Shannon E. Majowicz et al.   CLINICAL INFECTIOUS DISEASES

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Biological Insights from Structures of Two-Component Proteins

(2009) Rong Gao et al.   Annual Review of Microbiology

The Roles of Antimicrobial Peptides in Innate Host Defense

(2009) Gill Diamond et al.   CURRENT PHARMACEUTICAL DESIGN

The Hsp90 Inhibitor Radicicol Interacts with the ATP-Binding Pocket of Bacterial Sensor Kinase PhoQ

(2008) Michael T. Guarnieri et al.   JOURNAL OF MOLECULAR BIOLOGY

FDA Drug Approval Summary: Lapatinib in Combination with Capecitabine for Previously Treated Metastatic Breast Cancer That Overexpresses HER-2

(2008) Q. Ryan et al.   ONCOLOGIST