Arene Trifunctionalization with Highly Fused Ring Systems through a Domino Aryne Nucleophilic and Diels-Alder Cascade

Total Synthesis of Actinorhodin

(2019) Mamiko Ninomiya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Benzo[b]fluoranthenes and Spiroacridines from Fluorene-Derived Alkenes and N-Arylimines via a Tandem Reaction with Benzynes

(2019) Weihua Wang et al.   ORGANIC LETTERS

One-Pot, Three-Aryne Cascade Strategy for Naphthalene Formation from 1,3-Diynes and 1,2-Benzdiyne Equivalents

(2019) Xiao Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes

(2019) Yu Nakamura et al.   ORGANIC LETTERS

Recent advances in molecular rearrangements involving aryne intermediates

(2018) Tony Roy et al.   CHEMICAL COMMUNICATIONS

Domino Aryne Annulation via a Nucleophilic–Ene Process

(2018) Hai Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The domino hexadehydro-Diels–Alder reaction transforms polyynes to benzynes to naphthynes to anthracynes to tetracynes (and beyond?)

(2018) Xiao Xiao et al.   Nature Chemistry

Aryne Trifunctionalization Enabled by 3-Silylaryne as a 1,2-Benzdiyne Equivalent

(2018) Chunjie Lv et al.   ORGANIC LETTERS

Cyclohexenynone Precursors: Preparation via Oxidative Dearomatization Strategy and Reactivity

(2018) Dachuan Qiu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hypervalent Iodine/Triflate Hybrid Benzdiyne Equivalents: Access to Controlled Synthesis of Polycyclic Aromatic Compounds

(2017) Tsugio Kitamura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Aryne Formation via Grob Fragmentation from the [2+2] Cycloadducts of 3-Triflyloxyarynes

(2017) Jiarong Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ergot alkaloids: synthetic approaches to lysergic acid and clavine alkaloids

(2017) Haichao Liu et al.   NATURAL PRODUCT REPORTS

Reactions of hexadehydro-Diels–Alder benzynes with structurally complex multifunctional natural products

(2017) Sean P. Ross et al.   Nature Chemistry

Three-Component Coupling of Triflyloxy-Substituted Benzocyclobutenones, Organolithium Reagents, and Arynophiles Promoted by Generation of Aryne via Carbon–Carbon Bond Cleavage

(2017) Keisuke Uchida et al.   ORGANIC LETTERS

Total synthesis of aristolactam alkaloids via synergistic C–H bond activation and dehydro-Diels–Alder reactions

(2017) Mallu Chenna Reddy et al.   Chemical Science

Aryne Insertion into σ Bonds

(2017) Manjoorahmed Asamdi et al.   Asian Journal of Organic Chemistry

Employing Arynes in Diels–Alder Reactions and Transition-Metal-Free Multicomponent Coupling and Arylation Reactions

(2016) Sachin Suresh Bhojgude et al.   ACCOUNTS OF CHEMICAL RESEARCH

A C60-aryne building block: synthesis of a hybrid all-carbon nanostructure

(2016) D. García et al.   CHEMICAL COMMUNICATIONS

Reactions of arynes promoted by silver ions

(2016) Rajdip Karmakar et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of biaryls using aryne intermediates

(2016) José-Antonio García-López et al.   CHEMICAL SOCIETY REVIEWS

Aryne 1,2,3-Trifunctionalization with Aryl Allyl Sulfoxides

(2016) Yuanyuan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vicinal Diamination of Arenes with Domino Aryne Precursors

(2016) Lu Li et al.   ORGANIC LETTERS

Diamination of Domino Aryne Precursor with Sulfonamides

(2016) Dachuan Qiu et al.   ORGANIC LETTERS

Bis-corannulenoanthracene: An Angularly Fused Pentacene as a Precursor for Barrelene-Tethered Receptors for Fullerenes

(2016) K. G. Upul R. Kumarasinghe et al.   ORGANIC LETTERS

Substrates as Electron-Donor Precursors: Synthesis of Naphtho-Fused Oxindoles via Benzannulation of 2-Halobenzaldehydes and Indolin-2-ones

(2016) Feng-Cheng Jia et al.   ORGANIC LETTERS

Aryne Relay Chemistry en Route to Aminoarenes: Synthesis of 3-Aminoaryne Precursors via Regioselective Silylamination of 3-(Triflyloxy)arynes

(2016) Suguru Yoshida et al.   ORGANIC LETTERS

1,3- and 1,4-Benzdiyne equivalents for regioselective synthesis of polycyclic heterocycles

(2016) Takashi Ikawa et al.   Chemical Science

Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

(2015) Adam E. Goetz et al.   CHEMICAL COMMUNICATIONS

Domino Aryne Precursor: Efficient Construction of 2,4-Disubstituted Benzothiazoles

(2015) Jiarong Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aryne Reaction with γ-Arylallenylcarboxyamides: Unexpected Diels-Alder Cycloaddition

(2015) Haixing Fu et al.   Asian Journal of Organic Chemistry

From Perylene to a 22-Ring Aromatic Hydrocarbon in One-Pot

(2014) Bruno Schuler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Synthesis of 9-Aryldihydrophenanthrenes by a Cascade Reaction Involving Arynes and Styrenes

(2014) Sachin Suresh Bhojgude et al.   ORGANIC LETTERS

Tandem Diels-Alder/Coupling Reaction Involving Two Arynes: Highly Stereoselective Synthesis of Dihydronaphtho-Fused Oxindole

(2014) Shikuan Su et al.   Asian Journal of Organic Chemistry

Direct One-Pot Synthesis of Naphthoxindoles from 4-Bromooxindoles by Suzuki-Miyaura Coupling and Aldol Condensation Reactions

(2013) Kyeong-Yong Park et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Aryne Cycloaddition Reactions in the Synthesis of Large Polycyclic Aromatic Compounds

(2013) Dolores Pérez et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Alkane desaturation by concerted double hydrogen atom transfer to benzyne

(2013) Dawen Niu et al.   NATURE

The aromatic ene reaction

(2013) Dawen Niu et al.   Nature Chemistry

Alder-ene reaction of aryne with olefins

(2013) Zhao Chen et al.   TETRAHEDRON LETTERS

Catalytic Generation of Arynes and Trapping by Nucleophilic Addition and Iodination

(2012) Toshiyuki Hamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Arynes and Cyclohexyne in Natural Product Synthesis

(2012) Christian M. Gampe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Comprehensive History of Arynes in Natural Product Total Synthesis

(2012) Pamela M. Tadross et al.   CHEMICAL REVIEWS

Recent advances in transition-metal-free carbon–carbon and carbon–heteroatom bond-forming reactions using arynes

(2012) Anup Bhunia et al.   CHEMICAL SOCIETY REVIEWS

Double CH Functionalization in Sequential Order: Direct Synthesis of Polycyclic Compounds by a Palladium-Catalyzed CH Alkenylation-Arylation Cascade

(2012) Hiroaki Ohno et al.   CHEMISTRY-A EUROPEAN JOURNAL

Development of an Intramolecular Aryne Ene Reaction and Application to the Formal Synthesis of (±)-Crinine

(2012) David A. Candito et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The hexadehydro-Diels–Alder reaction

(2012) Thomas R. Hoye et al.   NATURE

Use of benzynes for the synthesis of heterocycles

(2012) Anton V. Dubrovskiy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Construction of Naphtho-Fused Oxindoles via the Aryne Diels–Alder Reaction with Methyleneindolinones

(2012) Jian Li et al.   ORGANIC LETTERS

[16]Cloverphene: a Clover-Shaped cata-Condensed Nanographene with Sixteen Fused Benzene Rings

(2011) José M. Alonso et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Fully Palladium-Mediated Construction of Phenanthrenes and Naphthoxindoles

(2011) Luma Nassar-Hardy et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Intramolecular Aryne–Ene Reaction: Synthetic and Mechanistic Studies

(2011) David A. Candito et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hexaradialenes by Successive Ring Openings of Tris(alkoxy-tricyclobutabenzenes): Synthesis and Characterization

(2010) Shinya Shinozaki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RECENT APPLICATIONS OF ARYNE CHEMISTRY TO ORGANIC SYNTHESIS. A REVIEW

(2009) Roberto Sanz   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL