Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3

B cell lymphoma with different metabolic characteristics show distinct sensitivities to metabolic inhibitors

(2018) Xiaoxia Liu et al.   Journal of Cancer

Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3

(2018) George Karageorgis et al.   Nature Chemistry

Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

(2017) Taro Ozaki et al.   Nature Communications

Identification of novel GLUT inhibitors

(2016) Holger Siebeneicher et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool

(2016) Ignacio Colomer et al.   CHEMICAL COMMUNICATIONS

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

(2016) Holger Siebeneicher et al.   ChemMedChem

Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

(2016) Haruhisa Kikuchi et al.   ORGANIC LETTERS

Anticancer agents interacting with membrane glucose transporters

(2016) C. Granchi et al.   MedChemComm

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Hide and seek: Identification and confirmation of small molecule protein targets

(2015) Andrei Ursu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides

(2015) Teigo Asai et al.   Nature Chemistry

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry

(2015) Holger Franken et al.   Nature Protocols

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

(2015) Anneleen Daemen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

One-Pot Synthesis of Azoline-Containing Peptides in a Cell-free Translation System Integrated with a Posttranslational Cyclodehydratase

(2014) Yuki Goto et al.   CHEMISTRY & BIOLOGY

Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms

(2014) Alvaro Marín-Hernández et al.   FEBS Journal

Biology-Oriented Synthesis: Harnessing the Power of Evolution

(2014) Hilde van Hattum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Complex and Diverse Compounds through Ring Distortion of Abietic Acid

(2013) Ryan J. Rafferty et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biomedical Importance of Indoles

(2013) Nagendra Kaushik et al.   MOLECULES

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

(2013) Robert W. Huigens III et al.   Nature Chemistry

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

The ChEMBL bioactivity database: an update

(2013) A. Patrícia Bento et al.   NUCLEIC ACIDS RESEARCH

Organocatalyzed Asymmetric Synthesis of Morphans

(2013) Ben Bradshaw et al.   ORGANIC LETTERS

Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries

(2012) Andreas Kirschning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expression of hypoxia-related glucose transporters GLUT1 and GLUT3 in benign, malignant and non-neoplastic thyroid lesions

(2012) PAWEŁ JÓźWIAK et al.   Molecular Medicine Reports

The generation of “unNatural” products: Synthetic biology meets synthetic chemistry

(2012) Rebecca J. M. Goss et al.   NATURAL PRODUCT REPORTS

Natural-product-derived fragments for fragment-based ligand discovery

(2012) Björn Over et al.   Nature Chemistry

Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers

(2012) Anna Krzeslak et al.   PATHOLOGY & ONCOLOGY RESEARCH

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An enzymatic fluorimetric assay to quantitate 2-deoxyglucose and 2-deoxyglucose-6-phosphate for in vitro and in vivo use

(2010) Norio Yamamoto et al.   ANALYTICAL BIOCHEMISTRY

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry

Asymmetric synthesis of 2-azabicyclo[3.3.1]nonanes by a microwave-assisted organocatalysed tandem desymmetrisation and intramolecular aldolisation

(2009) Faïza Diaba et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The facilitative glucose transporter GLUT3: 20 years of distinction

(2008) Ian A. Simpson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Epothilones as Lead Structures for the Synthesis-Based Discovery of New Chemotypes for Microtubule Stabilization

(2007) Fabian Feyen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Natural Product-likeness Score and Its Application for Prioritization of Compound Libraries

(2007) Peter Ertl et al.   Journal of Chemical Information and Modeling