Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides

Product identification of non-reducing polyketide synthases with C-terminus methyltransferase domain from Talaromyces stipitatus using Aspergillus oryzae heterologous expression

(2015) Makoto Hashimoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Systematic Domain Swaps of Iterative, Nonreducing Polyketide Synthases Provide a Mechanistic Understanding and Rationale For Catalytic Reprogramming

(2014) Adam G. Newman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases

(2014) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenovirus: Current Epidemiology and Emerging Approaches to Prevention and Treatment

(2014) Uriel Sandkovsky et al.   Current Infectious Disease Reports

Multiplexing of Combinatorial Chemistry in Antimycin Biosynthesis: Expansion of Molecular Diversity and Utility

(2013) Yan Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An Efficient System for Heterologous Expression of Secondary Metabolite Genes in Aspergillus nidulans

(2013) Yi-Ming Chiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconstitution of Biosynthetic Machinery for Indole-Diterpene Paxilline in Aspergillus oryzae

(2013) Koichi Tagami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocatalytic Synthesis of Pikromycin, Methymycin, Neomethymycin, Novamethymycin, and Ketomethymycin

(2013) Douglas A. Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

(2013) Robert W. Huigens III et al.   Nature Chemistry

Structurally Diverse Chaetophenol Productions Induced by Chemically Mediated Epigenetic Manipulation of Fungal Gene Expression

(2013) Teigo Asai et al.   ORGANIC LETTERS

Structures of Spiroindicumides A and B, Unprecedented Carbon Skeletal Spirolactones, and Determination of the Absolute Configuration by Vibrational Circular Dichroism Exciton Approach

(2013) Teigo Asai et al.   ORGANIC LETTERS

Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence

(2012) Zhongli Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries

(2012) Andreas Kirschning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Diversity Sculpted by Fungal PKS-NRPS Hybrids

(2012) Daniela Boettger et al.   CHEMBIOCHEM

Precursor-Directed Syntheses and Biological Evaluation of New Elansolid Derivatives

(2012) Heinrich Steinmetz et al.   CHEMBIOCHEM

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Molecular Library Synthesis Using Complex Substrates: Expanding the Framework of Triterpenoids

(2012) Vasily A. Ignatenko et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Akuammiline Alkaloid (−)-Vincorine via Intramolecular Oxidative Coupling

(2012) Weiwei Zi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Precursor Directed Biosynthesis of an Orthogonally Functional Erythromycin Analogue: Selectivity in the Ribosome Macrolide Binding Pocket

(2012) Colin J. B. Harvey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The generation of “unNatural” products: Synthetic biology meets synthetic chemistry

(2012) Rebecca J. M. Goss et al.   NATURAL PRODUCT REPORTS

Aromatic Polyketide Production in Cordyceps indigotica, an Entomopathogenic Fungus, Induced by Exposure to a Histone Deacetylase Inhibitor

(2012) Teigo Asai et al.   ORGANIC LETTERS

Synthetic diversification of natural products: semi-synthesis and evaluation of triazole jadomycins

(2012) Stephanie N. Dupuis et al.   Chemical Science

The Interplay between Mutasynthesis and Semisynthesis: Generation and Evaluation of an Ansamitocin Library

(2011) Simone Eichner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering of an “Unnatural” Natural Product by Swapping Polyketide Synthase Domains inAspergillus nidulans

(2011) Ting Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anticancer compounds derived from fungal endophytes: their importance and future challenges

(2011) Ravindra N. Kharwar et al.   NATURAL PRODUCT REPORTS

Remodelling of the natural product fumagillol employing a reaction discovery approach

(2011) Bradley R. Balthaser et al.   Nature Chemistry

Efficient Generation of ortho-Quinone Methide: Application to the Biomimetic Syntheses of (±)-Schefflone and Tocopherol Trimers

(2011) Daohong Liao et al.   ORGANIC LETTERS

Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase

(2011) H. Morita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SMURF: Genomic mapping of fungal secondary metabolite clusters

(2010) Nora Khaldi et al.   FUNGAL GENETICS AND BIOLOGY

Fungal secondary metabolites – Strategies to activate silent gene clusters

(2010) Axel A. Brakhage et al.   FUNGAL GENETICS AND BIOLOGY

Human adenovirus replication in immunocompetent Syrian hamsters can be attenuated with chlorpromazine or cidofovir

(2010) Iulia Diaconu et al.   JOURNAL OF GENE MEDICINE

Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives

(2010) Karl-Heinz Altmann et al.   MOLECULAR DIVERSITY

Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger

(2009) K. M. Fisch et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Novel Chemical Space Exploration via Natural Products

(2009) Josefin Rosén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triggering cryptic natural product biosynthesis in microorganisms

(2009) Kirstin Scherlach et al.   ORGANIC & BIOMOLECULAR CHEMISTRY