Stability and uniqueness of clonal immunoglobulin CDR3 sequences for MRD tracking in multiple myeloma

Commonality despite exceptional diversity in the baseline human antibody repertoire

(2019) Bryan Briney et al.   NATURE

Baseline identification of clonal V(D)J sequences for DNA-based minimal residual disease detection in multiple myeloma

(2019) Even H. Rustad et al.   PLoS One

High frequency of shared clonotypes in human B cell receptor repertoires

(2019) Cinque Soto et al.   NATURE

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Immunoglobulin gene analysis as a tool for investigating human immune responses

(2018) Deborah Dunn-Walters et al.   IMMUNOLOGICAL REVIEWS

Daratumumab plus Bortezomib, Melphalan, and Prednisone for Untreated Myeloma

(2018) María-Victoria Mateos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Minimal residual disease detection of myeloma using sequencing of immunoglobulin heavy chain gene VDJ regions

(2018) Caleb Ho et al.   SEMINARS IN HEMATOLOGY

MRD Testing in Multiple Myeloma: From a Surrogate Marker of Clinical Outcomes to an Every-Day Clinical Tool

(2018) Ola Landgren   SEMINARS IN HEMATOLOGY

Many Routes to an Antibody Heavy-Chain CDR3: Necessary, Yet Insufficient, for Specific Binding

(2018) Sara D’Angelo et al.   Frontiers in Immunology

Minimal residual disease negativity using deep sequencing is a major prognostic factor in multiple myeloma

(2018) Aurore Perrot et al.   BLOOD

Establishment of Immunoglobulin Heavy Chain Clonality Testing by Next-Generation Sequencing for Routine Characterization of B-Cell and Plasma Cell Neoplasms

(2018) Maria E. Arcila et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Monitoring multiple myeloma by quantification of recurrent mutations in serum

(2017) Even Holth Rustad et al.   HAEMATOLOGICA

Monitoring multiple myeloma by next-generation sequencing of V(D)J rearrangements from circulating myeloma cells and cell-free myeloma DNA

(2017) Anna Oberle et al.   HAEMATOLOGICA

Antigen receptor repertoire profiling from RNA-seq data

(2017) Dmitriy A Bolotin et al.   NATURE BIOTECHNOLOGY

Monitoring multiple myeloma by quantification of recurrent mutations in serum

(2017) Even Holth Rustad et al.   HAEMATOLOGICA

Monitoring multiple myeloma by next-generation sequencing of V(D)J rearrangements from circulating myeloma cells and cell-free myeloma DNA

(2017) Anna Oberle et al.   HAEMATOLOGICA

Association of Minimal Residual Disease With Superior Survival Outcomes in Patients With Multiple Myeloma

(2017) Nikhil C. Munshi et al.   JAMA Oncology

Assembly-based inference of B-cell receptor repertoires from short read RNA sequencing data with V’DJer

(2016) Lisle E. Mose et al.   BIOINFORMATICS

Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma

(2016) N. Weinhold et al.   BLOOD

Role of MRD status in relation to clinical outcomes in newly diagnosed multiple myeloma patients: a meta-analysis

(2016) O Landgren et al.   BONE MARROW TRANSPLANTATION

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT)

(2015) Donavan T. Cheng et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

The predominant myeloma clone at diagnosis, CDR3 defined, is constantly detectable across all stages of disease evolution

(2015) N Puig et al.   LEUKEMIA

MiXCR: software for comprehensive adaptive immunity profiling

(2015) Dmitriy A Bolotin et al.   NATURE METHODS

Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma

(2015) Graeme Cowan et al.   Oncotarget

VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires

(2015) Mikhail Shugay et al.   PLoS Computational Biology

Treatment With Carfilzomib-Lenalidomide-Dexamethasone With Lenalidomide Extension in Patients With Smoldering or Newly Diagnosed Multiple Myeloma

(2015) Neha Korde et al.   JAMA Oncology

Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy

(2014) Jens G. Lohr et al.   CANCER CELL

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

(2014) Niccolo Bolli et al.   Nature Communications

Using synthetic templates to design an unbiased multiplex PCR assay

(2013) Christopher S. Carlson et al.   Nature Communications

Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

(2012) J. B. Egan et al.   BLOOD

Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia

(2012) M. Faham et al.   BLOOD