Article
Engineering, Biomedical
Song Xue, Xiaojun Zhou, Weilin Sang, Cong Wang, Haiming Lu, Yiming Xu, Yiming Zhong, Libo Zhu, Chuanglong He, Jinzhong Ma
Summary: A novel cartilage-targeting dual-drug delivery system was designed to effectively treat osteoarthritis by sequentially releasing two agents. The system demonstrated excellent ROS scavenging ability and anti-apoptotic effects, while also enhancing autophagy activity and chondrocyte protection. It has the potential to be a promising therapy for osteoarthritis.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Wenqian Wu, Xiaonan Sun, Xiaomeng Shi, Lo Lai, Charles Wang, Mingxin Xie, Gangjian Qin, Hongyu Qiu
Summary: The study found that loss of Hsp22 can lead to progressive cardiac dilation and declining function, affecting BAG3 and its associated cardiac autophagy, disrupting cardiac energy metabolism homeostasis, and increasing oxidative damage.
Article
Cell Biology
Tao Li, Hongyu Zhao, Gaofeng Guo, Shuwei Xia, Likun Wang
Summary: By studying cells deficient in vacuole membrane protein 1 (VMP1), a regulator of the unfolded protein response (UPR), researchers have uncovered a model of UPR regulation in which the three signaling pathways are controlled in different ways. Under basal conditions, calcium binding activates PERK, while under ER stress, ER-mitochondria interaction-induced mitochondrial stress works with PERK to suppress IRE1a and ATF6 by slowing down protein synthesis. This sophisticated regulation limits UPR activation and protects cells from chronic ER stress.
Article
Plant Sciences
Ammar Elakhdar, Ahmed A. El-Naggar, Takahiko Kubo, Toshihiro Kumamaru
Summary: Drought is a major stress that leads to crop yield losses, and understanding the molecular mechanisms behind drought response is important for developing drought-tolerant crops. This study identified core drought-induced marker genes and regulatory networks in barley using morpho-physiological and comparative RNA sequencing analyses. The results revealed changes in several physiological and morphological traits in response to drought stress, and identified candidate genes that could mitigate water stress and be used for developing drought-resilient barley cultivars.
PHYSIOLOGIA PLANTARUM
(2023)
Article
Plant Sciences
Ali Raza, Wei Su, Muhammad Azhar Hussain, Sundas Saher Mehmood, Xuekun Zhang, Yong Cheng, Xiling Zou, Yan Lv
Summary: Rapeseed is an important oilseed crop and enhancing cold stress tolerance is crucial for agricultural investigation and crop improvement. This study identified stress-responsive genes, metabolites, and pathways in cold-tolerant and cold-sensitive rapeseed varieties. Functional analysis revealed the significance of starch and sucrose metabolism and phenylalanine metabolism in cold stress adaption. Six candidate genes were selected for controlling adaption to low temperature and showed significant differences in freezing tolerance.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Fisheries
Liulan Zhao, Ji Liang, Hao Liu, Chenxin Gong, Xiaoli Huang, Yifan Hu, Qiao Liu, Zhi He, Xin Zhang, Song Yang, Samad Rahimnejad
Summary: Our study demonstrated that the addition of Yinchenhao Decoction (YD) in a high carbohydrate diet (HCD) enhances endoplasmic reticulum stress, autophagy, and programmed apoptosis, maintaining homeostasis, reducing uncontrolled necroptosis and inflammation, and ultimately improving immune response in largemouth bass.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Plant Sciences
Yu Tian, Kankan Peng, Guicheng Lou, Zhipeng Ren, Xianze Sun, Zhengwei Wang, Jinpu Xing, Chunhua Song, Jing Cang
Summary: This study is the first to explore the transcriptome of Dn1 under cold stress, and comprehensively analyzed the key genes involved in cold signal transduction and carbohydrate metabolism in Dn1 under cold stress.
Article
Nutrition & Dietetics
Matthew G. Pontifex, Aleena Mushtaq, Gwenaelle Le Gall, Ildefonso Rodriguez-Ramiro, Britt Anne Blokker, Mara E. M. Hoogteijling, Matthew Ricci, Michael Pellizzon, David Vauzour, Michael Muller
Summary: The addition of inulin and psyllium individually resulted in distinct changes in gut microbiota, with psyllium also leading to reductions in blood sugar and diabetes-associated metabolites. A combination diet benefitted from both inulin and psyllium related microbial changes.
Review
Immunology
Kareem Awad, Amany Sayed Maghraby, Dina Nadeem Abd-Elshafy, Mahmoud Mohamed Bahgat
Summary: This study investigates the changes in carbohydrate metabolism in immune cells in different types of infectious diseases, aiming to provide reasonable strategies for the diagnosis, prognosis, and treatment of immune cells under alternative metabolic burdens.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Jinjing Cheng, Leilei Xiang, Meizhen Yang, Ying Liu, Luyi Pan, Zhenfei Guo, Shaoyun Lu
Summary: This study analyzed the transcriptomic profiling of Kentucky bluegrass cultivar 'Qinghai' in response to osmotic stress, and identified key genes involved in carbohydrate metabolism, polyamine and amino acid metabolism, and plant hormone signaling pathway. These findings provide promising candidate genes for studying drought mechanisms and improving drought tolerance in Kentucky bluegrass and drought-sensitive crops.
Article
Engineering, Environmental
Ying Zhang, Yaqi Jiao, Yue Tao, Zixu Li, Hui Yu, Siyue Han, Yang Yang
Summary: Monobutyl phthalate (MBP) can cause acute effects on zebrafish liver, including endoplasmic reticulum stress, lipid synthesis promotion, lipid droplet accumulation, and inhibition of glucose metabolism, leading to cell death and liver damage.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Nese Vardar Acar, Ali Dursun, Damla Aygun, H. Esra Gurses Cila, Incilay Lay, Basri Gulbakan, R. Koksal Ozgul
Summary: Oxidative stress is associated with the pathologies of various diseases including IEMs. p62/SQSTM1 protects cells from stress through the activation of Nrf2/Keap1 and autophagy pathways. Our study shows that measuring antioxidant and oxidant capacity alone cannot fully reflect the clinical picture of IEMs. Different IEMs exhibit distinct cellular stress, mitochondrial dysfunction, and autophagy profiles.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Plant Sciences
Yue Wang, Tao Liu, Changjian Ma, Guoqing Li, Xinhong Wang, Jianghui Wang, Jin Chang, Cong Guan, Huimin Yao, Xuehui Dong
Summary: Starch and sucrose showed opposing trends during dormancy release in P. kingianum rhizome bud, while galactose and raffinose increased. Glucose, cellulose, mannose, arabinose, rhamnose, and stachyose exhibited various changes. The metabolism of carbohydrates may shift from anaerobic oxidation to the tricarboxylic acid cycle and pentose phosphate pathway during dormancy release. Gene co-expression analysis indicated interactions between sugar and hormone signaling pathways in the regulatory network of dormancy release in P. kingianum rhizome buds.
Article
Cell Biology
Andrew Blum, Kate Mostow, Kailey Jackett, Estelle Kelty, Tenzing Dakpa, Carly Ryan, Engda Hagos
Summary: The study indicates that KLF4 plays a role in regulating cell metabolism and promoting energy production, which may be beneficial for cancer treatment.
Article
Physiology
C. Ruperez, A. Blasco-Roset, D. Kular, M. Cairo, G. Ferrer-Curriu, J. Villarroya, M. Zamora, F. Crispi, F. Villarroya, A. Planavila
Summary: This study investigates the reversibility of cold-induced cardiac hypertrophy and the role of autophagy in this process. The results show that exposure to cold leads to cardiac hypertrophy in mice, but this hypertrophy is fully reversed after 1 week of deacclimation. Autophagy is proposed as a major mechanism underlying the heart remodeling seen in response to cold exposure and its posterior reversion after deacclimation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Midori Umekawa, Masato Ujihara, Daiki Nakai, Hiromu Takematsu, Mamoru Wakayama
Article
Biochemistry & Molecular Biology
Yuko Naito-Matsui, Leela R. L. Davies, Hiromu Takematsu, Hsun-Hua Chou, Pam Tangvoranuntakul, Aaron F. Carlin, Andrea Verhagen, Charles J. Heyser, Seung-Wan Yoo, Biswa Choudhury, James C. Paton, Adrienne W. Paton, Nissi M. Varki, Ronald L. Schnaar, Ajit Varki
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Amin Alborzian Deh Sheikh, Chizuru Akatsu, Akihiro Imamura, Hajjaj H. M. Abdu-Allah, Hiromu Takematsu, Hiromune Ando, Hideharu Ishida, Takeshi Tsubata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Makoto Tomioka, Mitsugu Shimobayashi, Makoto Kitabatake, Mutsuhito Ohno, Yasunori Kozutsumi, Shogo Oka, Hiromu Takematsu
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Naoko Matsubara, Akihiro Imamura, Tatsuya Yonemizu, Chizuru Akatsu, Hongrui Yang, Akiharu Ueki, Natsuki Watanabe, Hajjaj Abdu-Allah, Nobutaka Numoto, Hiromu Takematsu, Shinobu Kitazume, Thomas F. Tedder, Jamey D. Marth, Nobutoshi Ito, Hiromune Ando, Hideharu Ishida, Makoto Kiso, Takeshi Tsubata
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Ayasa Nakamura, Jyoji Morise, Keiko Yabuno-Nakagawa, Yuki Hashimoto, Hiromu Takematsu, Shogo Oka
Article
Biochemistry & Molecular Biology
Zentaro Kiuchi, Yukino Nishibori, Satoru Kutsuna, Masashi Kotani, Ichiro Hada, Toru Kimura, Toshiyuki Fukutomi, Daisuke Fukuhara, Noriko Ito-Nitta, Akihiko Kudo, Takanobu Takata, Yasuhito Ishigaki, Naohisa Tomosugi, Hirotoshi Tanaka, Satsuki Matsushima, Shinya Ogasawara, Yoshiaki Hirayama, Hiromu Takematsu, Kunimasa Yan
Article
Multidisciplinary Sciences
Jyoji Morise, Kenichi G. N. Suzuki, Ayaka Kitagawa, Yoshihiko Wakazono, Kogo Takamiya, Taka A. Tsunoyama, Yuri L. Nemoto, Hiromu Takematsu, Akihiro Kusumi, Shogo Oka
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Midori Umekawa, Daiki Shiraishi, Marin Fuwa, Kazuna Sawaguchi, Yosuke Mashima, Takane Katayama, Shuichi Karita
Article
Immunology
Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hajjaj H. M. Abdu-Allah, Yuki Suganuma, Akihiro Imamura, Hiromune Ando, Hiromu Takematsu, Hideharu Ishida, Takeshi Tsubata
Summary: CD22 is an inhibitory B cell coreceptor that regulates B cell development and activation by downregulating BCR signaling. CD45 plays a crucial role in CD22-mediated inhibition of BCR signaling, while disruption of ligand binding of CD22 enhances CD22 phosphorylation. SHP-1 is required for ligand-mediated regulation of CD22 and dephosphorylates CD22 as well as other substrates to enhance BCR signaling.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Jhon R. Enterina, Susmita Sarkar, Laura Streith, Jaesoo Jung, Britni M. Arlian, Sarah J. Meyer, Hiromu Takematsu, Changchun Xiao, Troy A. Baldwin, Lars Nitschke, Mark J. Shlomchick, James C. Paulson, Matthew S. Macauley
Summary: Germinal centers are critical for antibody affinity maturation, and glycan remodeling plays a key role in maintaining B cells in the germinal center. Downregulation of CD22 ligands on B cells in the germinal center leads to increased apoptosis, reduced production of memory B cells and plasma cells, and delayed affinity maturation of antibodies. These defects are CD22 dependent.
Article
Biochemistry & Molecular Biology
Daichi Ito, Emiri Nakano, Shuichi Karita, Midori Umekawa, Khanok Ratanakhanokchai, Chakrit Tachaapaikoon
Summary: Paenibacillus xylaniclasticus strain TW1, isolated from pineapple processing factory wastes, possesses a novel xylanolytic enzyme PxXyl43A with an unknown carbohydrate-binding module. This enzyme shows potential in hydrolyzing xylan-containing polysaccharides.
JOURNAL OF APPLIED GLYCOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Daichi Ito, Shuichi Karita, Midori Umekawa
Summary: This study investigated the C1/C4-oxidizing selectivity of the LPMO PxAA10A as well as its boosting effect on cellulose degradation. The results showed that PxAA10A is a C1/C4-oxidizing LPMO and its addition to a cellulase cocktail improves cellulose degradation efficiency.
JOURNAL OF APPLIED GLYCOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Midori Umekawa, Kaito Hamada, Naoto Isono, Shuichi Karita
JOURNAL OF APPLIED GLYCOSCIENCE
(2020)
Article
Physiology
Hisashi Takagi, Yukino Nishibori, Kan Katayama, Tomohisa Katada, Shohei Takahashi, Zentaro Kiuchi, Shin-Ichiro Takahashi, Hiroyasu Kamei, Hayato Kawakami, Yoshihiro Akimoto, Akihiko Kudo, Katsuhiko Asanuma, Hiromu Takematsu, Kunimasa Yan
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)