CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma

Cancer statistics, 2023

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In vitro reconstitution of calcium-dependent recruitment of the human ESCRT machinery in lysosomal membrane repair

(2022) Sankalp Shukla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response

(2022) Zhaoting Li et al.   Nature Communications

Modelling membrane reshaping by staged polymerization of ESCRT-III filaments

(2022) Xiuyun Jiang et al.   PLoS Computational Biology

Channelling inflammation: gasdermins in physiology and disease

(2021) Xing Liu et al.   NATURE REVIEWS DRUG DISCOVERY

KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer

(2021) Ye Yang et al.   Translational Cancer Research

Design principles of the ESCRT-III Vps24-Vps2 module

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Knocking ’em Dead: Pore-Forming Proteins in Immune Defense

(2020) Xing Liu et al.   Annual Review of Immunology

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

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ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation

(2020) Aurélie Bertin et al.   Nature Communications

Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study

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Structure and assembly of ESCRT-III helical Vps24 filaments

(2020) Stefan T. Huber et al.   Science Advances

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

(2020) Jasper E. Neggers et al.   Cell Reports

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages

(2019) Philippa J. Goddard et al.   Cell Reports

ESCRT-III–dependent membrane repair blocks ferroptosis

(2019) Enyong Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Management Strategies for Recurrent Endometrial Cancer

(2018) Elizabeth V. Connor et al.   Expert Review of Anticancer Therapy

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability

(2018) Jessica B. A. Sadler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes

(2018) John McCullough et al.   Annual Review of Cell and Developmental Biology

ATP-dependent force generation and membrane scission by ESCRT-III and Vps4

(2018) Johannes Schöneberg et al.   SCIENCE

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

(2017) Zdenek Skrott et al.   NATURE

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

(2017) Beata E. Mierzwa et al.   NATURE CELL BIOLOGY

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

(2017) Siyun Kuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Checkpoint inhibitors in endometrial cancer: preclinical rationale and clinical activity

(2017) Gloria Mittica et al.   Oncotarget

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo

(2015) Peng Liu et al.   Oncotarget

Copper Signaling Axis as a Target for Prostate Cancer Therapeutics

(2014) R. Safi et al.   CANCER RESEARCH

Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

(2014) Jie Zha et al.   Journal of Translational Medicine

Hallmarks of Cancer: The Next Generation

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Chmp1A functions as a novel tumor suppressor gene in human embryonic kidney and ductal pancreatic tumor cells

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ALIX-CHMP4 interactions in the human ESCRT pathway

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