Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
出版年份 2019 全文链接
标题
Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
作者
关键词
-
出版物
Pharmaceutics
Volume 11, Issue 8, Pages 411
出版商
MDPI AG
发表日期
2019-08-13
DOI
10.3390/pharmaceutics11080411
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Propagation Characteristics of Fasting Duodeno-Jejunal Contractions in Healthy Controls Measured by Clustered Closely-spaced Manometric Sensors
- (2019) Jason R Baker et al. Journal of Neurogastroenterology and Motility
- Derivation of adult canine intestinal organoids for translational research in gastroenterology
- (2019) Lawrance Chandra et al. BMC BIOLOGY
- Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model
- (2019) D. Dahlgren et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs
- (2018) D. Dahlgren et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport
- (2018) D. Dahlgren et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition
- (2018) Masayuki Fujii et al. Cell Stem Cell
- IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds
- (2017) Alison Margolskee et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
- (2017) Alison Margolskee et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes
- (2017) Adam S. Darwich et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Integrative physiology of transcellular and paracellular intestinal absorption
- (2017) William H. Karasov JOURNAL OF EXPERIMENTAL BIOLOGY
- Predicting a Drug’s Membrane Permeability: A Computational Model Validated With in Vitro Permeability Assay Data
- (2017) Brian J. Bennion et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker 51Cr-EDTA
- (2017) David Dahlgren et al. MOLECULAR PHARMACEUTICS
- In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context
- (2017) H. Lennernäs et al. MOLECULAR PHARMACEUTICS
- Regional Intestinal Permeability in Rats: A Comparison of Methods
- (2017) Carl Roos et al. MOLECULAR PHARMACEUTICS
- Established and emerging methods for assessment of small and large intestinal motility
- (2017) D. Grønlund et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat—Biophysical Model and Predictions Based on Caco-2
- (2017) Isabel Lozoya-Agullo et al. PHARMACEUTICAL RESEARCH
- When barriers ignore the “rule-of-five”
- (2016) Stefanie D. Krämer et al. ADVANCED DRUG DELIVERY REVIEWS
- Molecular simulation of nonfacilitated membrane permeation
- (2016) Ernest Awoonor-Williams et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Use of physiologically relevant biopharmaceutics tools within the pharmaceutical industry and in regulatory sciences: Where are we now and what are the gaps?
- (2016) Talia Flanagan et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Simulation-Based Approaches for Determining Membrane Permeability of Small Compounds
- (2016) Christopher T. Lee et al. Journal of Chemical Information and Modeling
- IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies
- (2016) Lasse Saaby et al. MOLECULAR PHARMACEUTICS
- In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models
- (2016) Erik Sjögren et al. MOLECULAR PHARMACEUTICS
- Regional Intestinal Permeability of Three Model Drugs in Human
- (2016) David Dahlgren et al. MOLECULAR PHARMACEUTICS
- Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms
- (2016) David Dahlgren et al. MOLECULAR PHARMACEUTICS
- Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule: influence of age, gender, study country and testing protocol
- (2015) Y. T. Wang et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective
- (2015) HM Jones et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data
- (2015) Erik Sjögren et al. MOLECULAR PHARMACEUTICS
- pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion
- (2015) Yi Zheng et al. PHARMACEUTICAL RESEARCH
- Intestinal Water Absorption Varies with Expected Dietary Water Load among Bats but Does Not Drive Paracellular Nutrient Absorption
- (2015) Edwin R. Price et al. PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
- Conceptual barriers to understanding physical barriers
- (2015) Amulya Lingaraju et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Ion-Induced Defect Permeation of Lipid Membranes
- (2014) Igor Vorobyov et al. BIOPHYSICAL JOURNAL
- In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects
- (2014) Erik Sjögren et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition
- (2014) Dennis Smith et al. MOLECULAR PHARMACEUTICS
- Surface area of the digestive tract – revisited
- (2014) Herbert F Helander et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements
- (2013) Caroline A. Larregieu et al. AAPS Journal
- PBPK models for the prediction of in vivo performance of oral dosage forms
- (2013) Edmund S. Kostewicz et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Claudins and the Modulation of Tight Junction Permeability
- (2013) Dorothee Günzel et al. PHYSIOLOGICAL REVIEWS
- Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
- (2013) T. Sato et al. SCIENCE
- The Colon
- (2013) Rani S. Sellers et al. TOXICOLOGIC PATHOLOGY
- Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance
- (2013) Albert J. van Hell et al. Scientific Reports
- The selective cyclooxygenase-2 inhibitor parecoxib markedly improves the ability of the duodenum to regulate luminal hypertonicity in anaesthetized rats
- (2012) J. Sedin et al. Acta Physiologica
- Apple juice greatly reduces systemic exposure to atenolol
- (2012) Hyewon Jeon et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so
- (2012) Douglas B. Kell et al. DRUG DISCOVERY TODAY
- Comprehensive study on regional human intestinal permeability and prediction of fraction absorbed of drugs using the Ussing chamber technique
- (2012) Åsa Sjöberg et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Quantifying the chemical beauty of drugs
- (2012) G. Richard Bickerton et al. Nature Chemistry
- QSAR-based permeability model for drug-like compounds
- (2011) Rafael Gozalbes et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only
- (2011) Douglas B. Kell et al. DRUG DISCOVERY TODAY
- Microdosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1), and Interaction (Grapefruit Juice) Profiles of Celiprolol Following the Oral Microdose and Therapeutic Dose
- (2011) Ichiro Ieiri et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
- (2011) Alexander Alex et al. MedChemComm
- The impact of cyclooxygenase inhibition on duodenal motility and mucosal alkaline secretion in anaesthetized rats
- (2010) O. Nylander Acta Physiologica
- Validation of a differential in situ perfusion method with mesenteric blood sampling in rats for intestinal drug interaction profiling
- (2010) Joachim Brouwers et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Fruit juice inhibition of uptake transport: a new type of food-drug interaction
- (2010) David G. Bailey BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- How Well Can the Caco-2/Madin−Darby Canine Kidney Models Predict Effective Human Jejunal Permeability?†
- (2010) Alex Avdeef et al. JOURNAL OF MEDICINAL CHEMISTRY
- Intramolecular Hydrogen Bonding in Medicinal Chemistry
- (2010) Bernd Kuhn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Enabling the Intestinal Absorption of Highly Polar Antiviral Agents: Ion-Pair Facilitated Membrane Permeation of Zanamivir Heptyl Ester and Guanidino Oseltamivir
- (2010) Jonathan M. Miller et al. MOLECULAR PHARMACEUTICS
- Coexistence of passive and carrier-mediated processes in drug transport
- (2010) Kiyohiko Sugano et al. NATURE REVIEWS DRUG DISCOVERY
- Permeability of drugs and hormones through a lipid bilayer: insights from dual-resolution molecular dynamics
- (2010) Mario Orsi et al. Soft Matter
- In silicoPrediction of Human Oral Absorption Based on QSAR Analyses of PAMPA Permeability
- (2009) Miki Akamatsu et al. CHEMISTRY & BIODIVERSITY
- How to Recognize and Workaround Pitfalls in QSAR Studies: A Critical Review
- (2009) T. Scior et al. CURRENT MEDICINAL CHEMISTRY
- INTESTINAL PERFUSION WITH MESENTERIC BLOOD SAMPLING IN WILD-TYPE AND KNOCKOUT MICE: Evaluation of a Novel Tool in Biopharmaceutical Drug Profiling
- (2009) R. Mols et al. DRUG METABOLISM AND DISPOSITION
- Introduction to computational oral absorption simulation
- (2009) Kiyohiko Sugano Expert Opinion on Drug Metabolism & Toxicology
- Free Energy for the Permeation of Na+and Cl−Ions and Their Ion-Pair through a Zwitterionic Dimyristoyl Phosphatidylcholine Lipid Bilayer by Umbrella Integration with Harmonic Fourier Beads
- (2009) Ilja V. Khavrutskii et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Toward an Increased Understanding of the Barriers to Colonic Drug Absorption in Humans: Implications for Early Controlled Release Candidate Assessment
- (2009) Christer Tannergren et al. MOLECULAR PHARMACEUTICS
- Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories
- (2008) Rose Hayeshi et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol
- (2008) Yukio Kato et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes
- (2008) Shinsuke Nakagawa et al. NEUROCHEMISTRY INTERNATIONAL
- Microdosing Assessment to Evaluate Pharmacokinetics and Drug Metabolism in Rats Using Liquid Chromatography-Tandem Mass Spectrometry
- (2008) Jinsong Ni et al. PHARMACEUTICAL RESEARCH
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