The nucleosome: orchestrating DNA damage signaling and repair within chromatin

Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks

(2016) Ozge Gursoy-Yuzugullu et al.   JOURNAL OF MOLECULAR BIOLOGY

Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome

(2016) Qianglin Fang et al.   eLife

Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners

(2015) H. F. O'Connor et al.   EMBO REPORTS

Removal of H2A.Z by INO80 promotes homologous recombination

(2015) H. E. Alatwi et al.   EMBO REPORTS

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

(2015) Fade Gong et al.   GENES & DEVELOPMENT

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

(2015) Tina Thorslund et al.   NATURE

Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair

(2015) Ozge Gursoy-Yuzugullu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Featuring the nucleosome surface as a therapeutic target

(2015) Isabel Torres Gomes da Silva et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Histone Variants and Epigenetics

(2015) Steven Henikoff et al.   Cold Spring Harbor Perspectives in Biology

BMI1–RING1B is an autoinhibited RING E3 ubiquitin ligase

(2015) Asad M. Taherbhoy et al.   Nature Communications

RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage

(2015) Marco Gatti et al.   Cell Reports

The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in Saccharomyces cerevisiae

(2015) Christine E. Cucinotta et al.   PLoS Genetics

Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z

(2014) Zhuo Mao et al.   CELL RESEARCH

Nucleosome Structure and Function

(2014) Robert K. McGinty et al.   CHEMICAL REVIEWS

Double strand break (DSB) repair in heterochromatin and heterochromatin proteins in DSB repair

(2014) Charlène Lemaître et al.   DNA REPAIR

ANP32E is a histone chaperone that removes H2A.Z from chromatin

(2014) Arnaud Obri et al.   NATURE

Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome

(2014) Robert K. McGinty et al.   NATURE

Unravelling the genomic targets of small molecules using high-throughput sequencing

(2014) Raphaël Rodriguez et al.   NATURE REVIEWS GENETICS

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks

(2014) Pierre-Alexandre Vidi et al.   NUCLEIC ACIDS RESEARCH

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

(2014) M. K. Ayrapetov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A

(2014) Francesca Mattiroli et al.   Nature Communications

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

(2014) Simran Khurana et al.   Cell Reports

BRCA1 Is a Histone-H2A-Specific Ubiquitin Ligase

(2014) Reinhard Kalb et al.   Cell Reports

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

(2014) Sophia X. Pfister et al.   Cell Reports

Isolation of Chromatin from Dysfunctional Telomeres Reveals an Important Role for Ring1b in NHEJ-Mediated Chromosome Fusions

(2014) Cristina Bartocci et al.   Cell Reports

Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling

(2014) Justin W. Leung et al.   PLoS Genetics

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

(2014) Sílvia Carvalho et al.   eLife

The Chromatin Response to DNA Breaks: Leaving a Mark on Genome Integrity

(2013) Godelieve Smeenk et al.   Annual Review of Biochemistry

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

H2A.Z depletion impairs proliferation and viability but not DNA double-strand breaks repair in human immortalized and tumoral cell lines

(2013) Gemael-Cedrick Taty-Taty et al.   CELL CYCLE

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

(2013) Kahlin Cheung-Ong et al.   CHEMISTRY & BIOLOGY

Nucleosome remodelers in double-strand break repair

(2013) Andrew Seeber et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway

(2013) XIAOLEI LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Histone Acetyltransferase 1 Promotes Homologous Recombination in DNA Repair by Facilitating Histone Turnover

(2013) Xiaohan Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Molecule Inhibitor of Polycomb Repressive Complex 1 Inhibits Ubiquitin Signaling at DNA Double-strand Breaks

(2013) Ismail Hassan Ismail et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the nucleosome acidic patch in modulating higher order chromatin structure

(2013) A. A. Kalashnikova et al.   Journal of the Royal Society Interface

Human Cytomegalovirus Major Immediate Early 1 Protein Targets Host Chromosomes by Docking to the Acidic Pocket on the Nucleosome Surface

(2013) K. Mucke et al.   JOURNAL OF VIROLOGY

RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination

(2013) Teng Ma et al.   MOLECULAR CELL

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

Double strand break repair functions of histone H2AX

(2013) Ralph Scully et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation

(2013) Fade Gong et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

Self-renewal as a therapeutic target in human colorectal cancer

(2013) Antonija Kreso et al.   NATURE MEDICINE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-C

(2013) H. Kato et al.   SCIENCE

Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair

(2013) K.-Y. Hsiao et al.   Journal of Molecular Cell Biology

Nucleosome Dynamics as Modular Systems that Integrate DNA Damage and Repair

(2013) C. L. Peterson et al.   Cold Spring Harbor Perspectives in Biology

Histone marks: repairing DNA breaks within the context of chromatin

(2012) Kyle M. Miller et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ascending the nucleosome face: Recognition and function of structured domains in the histone H2A–H2B dimer

(2012) John J. Wyrick et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase

(2012) Marco Gatti et al.   CELL CYCLE

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

(2012) Martijn S Luijsterburg et al.   EMBO JOURNAL

Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases

(2012) Timothy P Wakeman et al.   EMBO JOURNAL

The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1

(2012) Chang Xu et al.   FEBS LETTERS

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling

(2012) G. Smeenk et al.   JOURNAL OF CELL SCIENCE

Mammalian Ino80 Mediates Double-Strand Break Repair through Its Role in DNA End Strand Resection

(2012) A. Gospodinov et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic Identification of Functional Residues in Mammalian Histone H2AX

(2012) W.-T. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Prime, Repair, Restore: The Active Role of Chromatin in the DNA Damage Response

(2012) Gaston Soria et al.   MOLECULAR CELL

Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair

(2012) Ye Xu et al.   MOLECULAR CELL

Perceiving the epigenetic landscape through histone readers

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H2A variants in nucleosomes and chromatin: more or less stable?

(2012) C. Bonisch et al.   NUCLEIC ACIDS RESEARCH

Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks

(2012) Andrea J. Hartlerode et al.   PLoS One

Links between genome integrity and BRCA1 tumor suppression

(2012) Mischa L. Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chromatin dynamics and the repair of DNA double strand breaks

(2011) Ye Xu et al.   CELL CYCLE

Recognizing and remodeling the nucleosome

(2011) Sebastian Glatt et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex

(2011) Matthew L Bentley et al.   EMBO JOURNAL

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Oligomerization of MDC1 Protein Is Important for Proper DNA Damage Response

(2011) Kuntian Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMI1 as a novel target for drug discovery in cancer

(2011) Liangxian Cao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair

(2011) V. Ginjala et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

(2011) Kyosuke Nakamura et al.   MOLECULAR CELL

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

Chromatin and the DNA damage response: The cancer connection

(2011) Martijn S. Luijsterburg et al.   Molecular Oncology

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors

(2011) H Ogiwara et al.   ONCOGENE

Architecture of the high mobility group nucleosomal protein 2-nucleosome complex as revealed by methyl-based NMR

(2011) H. Kato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An anticlastogenic function for the Polycomb Group gene Bmi1

(2011) J. Chagraoui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Silencing: Sir3 BAH Domain in Complex with a Nucleosome at 3.0 A Resolution

(2011) K.-J. Armache et al.   SCIENCE

BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

(2011) R. Shakya et al.   SCIENCE

Chromatin response to DNA double-strand break damage

(2011) Yunhe Bao   Epigenomics

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex

(2010) Catherine Chailleux et al.   BIOCHEMICAL JOURNAL

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Epigenetic Modifications in Double-Strand Break DNA Damage Signaling and Repair

(2010) D. Rossetto et al.   CLINICAL CANCER RESEARCH

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

(2010) Aaron A. Goodarzi et al.   DNA REPAIR

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

(2010) Sophie E Polo et al.   EMBO JOURNAL

A cooperative activation loop among SWI/SNF, γ-H2AX and H3 acetylation for DNA double-strand break repair

(2010) Han-Sae Lee et al.   EMBO JOURNAL

Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway

(2010) Xiaofeng Jiang et al.   FEBS LETTERS

p300-mediated Acetylation of Histone H3 Lysine 56 Functions in DNA Damage Response in Mammals

(2010) Rahul K. Vempati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

(2010) Ye Xu et al.   JOURNAL OF CELL BIOLOGY

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

(2010) Godelieve Smeenk et al.   JOURNAL OF CELL BIOLOGY

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

(2010) Dorthe Helena Larsen et al.   JOURNAL OF CELL BIOLOGY

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

(2010) Ismail Hassan Ismail et al.   JOURNAL OF CELL BIOLOGY

BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery

(2010) S. Facchino et al.   JOURNAL OF NEUROSCIENCE

MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

(2010) G. G. Sharma et al.   MOLECULAR AND CELLULAR BIOLOGY

MOF and H4 K16 Acetylation Play Important Roles in DNA Damage Repair by Modulating Recruitment of DNA Damage Repair Protein Mdc1

(2010) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

The ACF1 Complex Is Required for DNA Double-Strand Break Repair in Human Cells

(2010) Li Lan et al.   MOLECULAR CELL

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

(2010) Ragnhild Eskeland et al.   MOLECULAR CELL

Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage

(2010) Hisanobu Oda et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Structure of RCC1 chromatin factor bound to the nucleosome core particle

(2010) Ravindra D. Makde et al.   NATURE

H2A.Z nucleosomes enriched over active genes are homotypic

(2010) Christopher M Weber et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA resection in eukaryotes: deciding how to fix the break

(2010) Pablo Huertas   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

(2010) S. Fnu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

Regulatory ubiquitylation in response to DNA double-strand breaks

(2009) Stephanie Panier et al.   DNA REPAIR

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells

(2009) Jorrit V Tjeertes et al.   EMBO JOURNAL

BBAP Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response

(2009) Qingsheng Yan et al.   MOLECULAR CELL

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

(2009) Velibor Savic et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

(2009) Yingli Sun et al.   NATURE CELL BIOLOGY

The emerging role of nuclear architecture in DNA repair and genome maintenance

(2009) Tom Misteli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

(2009) Gyula Timinszky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polycomb Group Protein Bmi1 Is Required for Growth of RAF Driven Non-Small-Cell Lung Cancer

(2009) Matthias Becker et al.   PLoS One

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Histones: Annotating Chromatin

(2008) Eric I. Campos et al.   Annual Review of Genetics

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

(2008) J Ross Chapman et al.   EMBO REPORTS

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A–H2B acidic pocket

(2008) Lucie Roussel et al.   EMBO REPORTS

30 nm Chromatin Fibre Decompaction Requires both H4-K16 Acetylation and Linker Histone Eviction

(2008) Philip J.J. Robinson et al.   JOURNAL OF MOLECULAR BIOLOGY

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

(2008) Nabieh Ayoub et al.   NATURE

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

(2008) Andrew Xiao et al.   NATURE

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

(2008) Yong-Chul Kim et al.   NATURE CELL BIOLOGY