Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice

Thymoquinone increases the expression of neuroprotective proteins while decreasing the expression of pro-inflammatory cytokines and the gene expression NFκB pathway signaling targets in LPS/IFNγ -activated BV-2 microglia cells

(2018) Makini K. Cobourne-Duval et al.   JOURNAL OF NEUROIMMUNOLOGY

Post-stroke inflammation—target or tool for therapy?

(2018) Kate Lykke Lambertsen et al.   ACTA NEUROPATHOLOGICA

High content analysis of phagocytic activity and cell morphology with PuntoMorph

(2017) Hassan Al-Ali et al.   JOURNAL OF NEUROSCIENCE METHODS

Neuroprotective effects of hydrogen sulfide on sodium azide-induced autophagic cell death in PC12 cells

(2017) Haiyan Shan et al.   Molecular Medicine Reports

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

(2017) Kathryn P. MacPherson et al.   NEUROBIOLOGY OF DISEASE

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2017) Han Gao et al.   Cell Reports

3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S

(2017) Yuka Kimura et al.   Scientific Reports

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

(2016) Bettina Hjelm Clausen et al.   ACTA NEUROPATHOLOGICA

Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia

(2016) Pernille M Madsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibiting tumor necrosis factor-α before amyloidosis prevents synaptic deficits in an Alzheimer's disease model

(2016) Chelsea Cavanagh et al.   NEUROBIOLOGY OF AGING

Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

(2016) Bettina Hjelm Clausen et al.   Scientific Reports

Professional phagocytic granulocyte-derived PGD2 regulates the resolution of inflammation in fish

(2015) Victoria Gómez-Abellán et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli

(2015) James C. Cronk et al.   IMMUNITY

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways

(2015) Wen-Lin Chen et al.   REVIEWS IN THE NEUROSCIENCES

State of the art paper Tumor necrosis factor inhibitors – state of knowledge

(2015) Krzysztof Lis et al.   Archives of Medical Science

Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease

(2014) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

Soluble, but Not Transmembrane, TNF-  Is Required during Influenza Infection To Limit the Magnitude of Immune Responses and the Extent of Immunopathology

(2014) M. P. DeBerge et al.   JOURNAL OF IMMUNOLOGY

Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia

(2014) Bettina Clausen et al.   Journal of Neuroinflammation

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

(2014) Zhiwei Tang et al.   Journal of Neuroinflammation

Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice

(2014) Hans G Novrup et al.   Journal of Neuroinflammation

CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice

(2013) Stefano Fumagalli et al.   GLIA

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

(2013) Helena W Morrison et al.   Journal of Neuroinflammation

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

TNFα induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathway

(2013) F Marques-Fernandez et al.   Cell Death & Disease

Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury

(2012) Edward Tobinick et al.   CNS DRUGS

Inflammatory Cytokines in Experimental and Human Stroke

(2012) Kate Lykke Lambertsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Protection from Stroke with Intravenous TNFα Decoy Receptor-Trojan Horse Fusion Protein

(2012) Rachita K Sumbria et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway

(2012) Bradley K. Wacker et al.   JOURNAL OF NEUROCHEMISTRY

Vimentin participates in microglia activation and neurotoxicity in cerebral ischemia

(2012) Susan X. Jiang et al.   JOURNAL OF NEUROCHEMISTRY

CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke

(2012) Ann M Stowe et al.   Journal of Neuroinflammation

Phosphorylation of HSP27 by Protein Kinase D Is Essential for Mediating Neuroprotection against Ischemic Neuronal Injury

(2012) R. A. Stetler et al.   JOURNAL OF NEUROSCIENCE

Infarct Volume Is a Pivotal Biomarker After Intra-Arterial Stroke Therapy

(2012) Albert J. Yoo et al.   STROKE

Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe

(2012) Neil Dufton et al.   Scientific Reports

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

(2011) Roberta Brambilla et al.   BRAIN

Rapid Improvement of Chronic Stroke Deficits after Perispinal Etanercept

(2011) Edward Tobinick   CNS DRUGS

The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization

(2011) Sirish K Ippagunta et al.   NATURE IMMUNOLOGY

Reactivation of M. tuberculosis Infection in Trans-Membrane Tumour Necrosis Factor Mice

(2011) Ivy Dambuza et al.   PLoS One

Heat shock proteins: Cellular and molecular mechanisms in the central nervous system

(2010) R. Anne Stetler et al.   PROGRESS IN NEUROBIOLOGY

Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor

(2009) K. L. Lambertsen et al.   JOURNAL OF NEUROSCIENCE

Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice

(2009) M. Liu et al.   NEUROSCIENCE

Hydrogen sulfide is an endogenous stimulator of angiogenesis

(2009) A. Papapetropoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proapoptotic Role of Human Growth and Transformation-Dependent Protein in the Developing Rat Brain After Hypoxia-Ischemia

(2009) Yi Qu et al.   STROKE

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Perispinal etanercept: Potential as an Alzheimer therapeutic

(2008) W Sue T Griffin   Journal of Neuroinflammation

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

(2008) Bettina H Clausen et al.   Journal of Neuroinflammation

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase

(2008) M. O. Breckwoldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated Activity and Microglial Expression of Myeloperoxidase in Demyelinated Cerebral Cortex in Multiple Sclerosis

(2007) Elizabeth Gray et al.   BRAIN PATHOLOGY