Article
Cell Biology
P. Brancaccio, S. Anzilotti, O. Cuomo, A. Vinciguerra, M. Campanile, A. Herchuelz, S. Amoroso, L. Annunziato, G. Pignataro
Summary: Researchers are studying endogenous neuroprotective strategies to identify alternative interventions for neonatal hypoxic-ischemic encephalopathy. They found that hypoxic preconditioning can promote neurogenesis and provide neuroprotection by regulating ionic homeostasis.
CELL DEATH DISCOVERY
(2022)
Article
Chemistry, Physical
Xin-Chi Jiang, Hong-Hui Wu, Tianyuan Zhang, Yun-Fei Dong, Yao-Sheng Li, Ting Huang, An-Hao Tian, Peng-Xiang Chen, Xian-Ming Lin, Ying-Zhi Huang, Chong Liu, Xiang-Nan Zhang, Zhong Chen, Yasuhiko Tabata, Jian-Qing Gao
Summary: Hypoxic preconditioning of neural stem cells (NSCs) can produce hypoxic exosomes, which can effectively treat ischemic stroke. These exosomes can target the injured brain and regulate the microenvironment to inhibit neuroinflammation and promote blood-brain barrier permeability recovery. Furthermore, they can also activate autologous NSCs and facilitate nerve regeneration. Hypoxic exosomes have therapeutic effects on both survival and behavioral outcomes in ischemic stroke mice.
Article
Cell Biology
Rafael Torosyan, Shengping Huang, Prashant Bommi, Ratnakar Tiwari, Si Young An, Michael Schonfeld, Ganeshkumar Rajendran, Matthew A. Kavanaugh, Benjamin Gibbs, Agnieszka D. Truax, Samuel Bohney, M. Wade Calcutt, Evan W. Kerr, Roberta Leonardi, Peng Gao, Navdeep S. Chandel, Pinelopi P. Kapitsinou
Summary: The study found that hypoxic preconditioning and PHD inhibition increase serum kynurenine levels, protecting the kidney from damage. The IDO1-kynurenine axis plays a critical role in mediating hypoxic preconditioning.
Review
Clinical Neurology
Sherif Hafez, Zeina Eid, Sara Alabasi, Yasenya Darwiche, Sara Channaoui, David C. Hess
Summary: Ischemic stroke is a leading cause of death and disability, with tissue plasminogen activator being the only FDA approved thrombolytic therapy. However, its use is limited due to increased risk of bleeding and narrow therapeutic window. There is a need for alternative therapeutic approaches that can enhance neuroprotection and reduce the risk of stroke.
Article
Neurosciences
Stephan Schacke, Joanna Kirkpatrick, Amy Stocksdale, Reinhard Bauer, Christian Hagel, Lars Bjoern Riecken, Helen Morrison
Summary: Astrocytes play a crucial role in brain function and behavior through their involvement in synaptic signaling and ion homeostasis. Ezrin, an essential protein in astrocytes, has been found to contribute to synaptic transmission and astrocyte activation. Deletion of Ezrin in mice resulted in behavioral changes and showed a protective effect in an experimental ischemic stroke. These findings suggest the importance of Ezrin in astrocyte functions and its potential therapeutic implications.
Article
Medicine, Research & Experimental
Bin Liu, Liping Xiang, Jing Ji, Wei Liu, Ying Chen, Mingfeng Xia, Yuejun Liu, Wenyue Liu, Peiwu Zhu, Yi Jin, Yu Han, Jieli Lu, Xiaoying Li, Minghua Zheng, Yan Lu
Summary: This study identified increased expression of Sparcl1 in WAT from NASH mice and patients, positively correlated with hepatic pathological features. Sparcl1 promoted CCL2 expression in hepatocytes through TLR4 and NF-KB/p65 pathway, leading to hepatic inflammatory response. Blocking CCL2/CCR2 pathway attenuated the inflammatory response evoked by Sparcl1, suggesting Sparcl1 as a potential therapeutic target for NASH.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Jing Chen, Fei Xiao, Lifei Chen, Zhan Zhou, Yi Wei, Yu Zhong, Li Li, Yubo Xie
Summary: An increasing number of studies have reported that the neurotoxicity of propofol may cause long-term learning and cognitive dysfunction. Hypoxic preconditioning has been shown to have neuroprotective effects, reducing the neurotoxicity of propofol. However, it is unclear whether hypoxic preconditioning reduces propofol neurotoxicity associated with ferroptosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Radu Gabriel Hertzog, Nicoleta Simona Bicheru, Diana Mihaela Popescu, Octavian Calborean, Ana-Maria Catrina
Summary: Hypoxia, characterized by low oxygen concentration, is crucial for cellular responses and metabolism. Hypoxic preconditioning (HPC) shows potential benefits in promoting cell survival, angiogenesis, erythropoiesis, and anti-inflammatory responses, making it a promising approach for therapeutic intervention in various pathologies, including COVID-19.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Yuan-Pan Guo, Shan-Shan Pan
Summary: The study found that exercise preconditioning (EP) can improve the electrocardiographic (ECG) signs of myocardial ischemic/hypoxic injury and reduce the occurrence of malignant arrhythmias after exhaustive exercise.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Peter Galis, Linda Bartosova, Veronika Farkasova, Adrian Szobi, Csaba Horvath, Dominika Kovacova, Adriana Adameova, Tomas Rajtik
Summary: Intermittent hypoxic preconditioning (IHP) is an effective cardioprotective intervention that has demonstrated improvement in cardiac output in a model of doxorubicin-induced cardiomyopathy. This improvement is likely due to increased expression of SERCA2a, suggesting the potential of IHP as a protective intervention in doxorubicin cardiomyopathy. However, further analysis is still required to fully understand the observed effects.
CARDIOVASCULAR TOXICOLOGY
(2023)
Article
Cell Biology
Yue Huang, Shan- Shan Pan, Yuan-Pan Guo, Jia-Yin Wang, Dong-Feng Wan, Tian-Ran Chen, Jian-Qi Yuan
Summary: This study evaluated the effects of exercise preconditioning (EP) on myocardial ischemic/hypoxic injury and found that EP can alleviate exhaustive exercise-induced injury. Different staining methods, including HBFP and C-2R BG, were shown to be suitable for specifically visualizing myocardial ischemic/hypoxic injury in histological studies.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)
Review
Neurosciences
Jia Liu, Yakun Gu, Mengyuan Guo, Xunming Ji
Summary: The brain, as the organ with the highest oxygen demand, has poor tolerance to ischemia and hypoxia. Ischemic/hypoxic preconditioning has been studied as an effective strategy to improve tolerance and is considered significant in treating CNS diseases. It involves multiple protective mechanisms and is a research frontier in neurotherapy, with challenges in translating from basic research to clinical application.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Cell Biology
Yi Zhuo, Wei Chen, Wenshui Li, Yan Huang, Da Duan, Lite Ge, Jialin He, Jianyang Liu, Zhiping Hu, Ming Lu
Summary: The study successfully cultured olfactory mucosa mesenchymal stem cells (OM-MSCs) for the treatment of ischemic stroke, demonstrating that ischemic-hypoxic preconditioned OM-MSCs could effectively protect mitochondrial function, inhibit apoptosis, and pyroptosis of neurons.
Article
Physiology
Badr Khbouz, Francois Lallemand, Arianna Cirillo, Pascal Rowart, David Legouis, Nor Eddine Sounni, Agnes Noel, Pascal De Tullio, Sophie de Seigneux, Francois Jouret
Summary: This study investigates the protective effects and mechanisms of kidney-centered irradiation against renal ischemia-reperfusion injury (I/R). Kidney irradiation increased vascular surface in the renal parenchyma and conferred resistance against renal I/R damage. These findings suggest potential strategies for the treatment of ischemic acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ming Cai, Xuan Chen, Jieling Shan, Ruoyu Yang, Qi Guo, Xia Bi, Ping Xu, Xiangrong Shi, Lixi Chu, Liyan Wang
Summary: COVID-19 is a highly infectious respiratory virus that can cause respiratory failure and death in severe cases. Intermittent hypoxic preconditioning has positive effects on improving cardiopulmonary function and adaptability in patients, potentially aiding in the rehabilitation of COVID-19 patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Arend M. Hamming, Marieke J. H. Wermer, S. Umesh Rudrapatna, Christian Lanier, Hine J. A. van Os, Walter M. van den Bergh, Michel D. Ferrari, Annette van der Toorn, Arn M. J. M. van den Maagdenberg, Ann M. Stowe, Rick M. Dijkhuizen
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2016)
Article
Cell Biology
Sterling B. Ortega, Xiagmei Kong, Ramgopal Venkataraman, Allen Michael Savedra, Steven G. Kernie, Ann M. Stowe, Lakshmi Raman
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Clinical Neurology
Jacqueline R. Rivas, Sara J. Ireland, Rati Chkheidze, William H. Rounds, Joseph Lim, Jordan Johnson, Denise M. O. Ramirez, Ann J. Ligocki, Ding Chen, Alyssa A. Guzman, Mark Woodhall, Patrick C. Wilson, Eric Meffre, Charles White, Benjamin M. Greenberg, Patrick Waters, Lindsay G. Cowell, Ann M. Stowe, Nancy L. Monson
ACTA NEUROPATHOLOGICA
(2017)
Article
Endocrinology & Metabolism
Uma Maheswari Selvaraj, Sterling B. Ortega, Ruilong Hu, Robert Gilchrist, Xiangmei Kong, Alexander Partin, Erik J. Plautz, Robyn S. Klein, Jeffrey M. Gidday, Ann M. Stowe
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Biochemical Research Methods
Jie-Min Jia, Praveen D. Chowdary, Xiaofei Gao, Bo Ci, Wenjun Li, Aditi Mulgaonkar, Erik J. Plautz, Gedaa Hassan, Amit Kumar, Ann M. Stowe, Shao-Hua Yang, Wei Zhou, Xiankai Sun, Bianxiao Cui, Woo-Ping Ge
Review
Clinical Neurology
Uma Maheswari Selvaraj, Katherine Poinsatte, Vanessa Torres, Sterling B. Ortega, Ann M. Stowe
Article
Clinical Neurology
Arend M. Hamming, Annette van der Toorn, Umesh S. Rudrapatna, Lisha Ma, Hine J. A. van Os, Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Erik van Zwet, Katherine Poinsatte, Ann M. Stowe, Rick M. Dijkhuizen, Marieke J. H. Wermer
Article
Immunology
Ann M. Stowe, Sara J. Ireland, Sterling B. Ortega, Ding Chen, Ryan M. Huebinger, Takashi Tarumi, Thomas S. Harris, C. Munro Cullum, Roger Rosenberg, Nancy L. Monson, Rong Zhang
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Clinical Neurology
Amanda Dirickson, Sonja E. Stutzman, Mark J. Alberts, Roberta L. Novakovic, Ann M. Stowe, Claudia C. Beal, Mark P. Goldberg, DaiWai M. Olson
JOURNAL OF NEUROSCIENCE NURSING
(2017)
Article
Critical Care Medicine
Sterling B. Ortega, Poornima Pandiyan, Jana Windsor, Vanessa O. Torres, Uma M. Selvaraj, Amy Lee, Michael Morriss, Fenghua Tian, Lakshmi Raman, Ann M. Stowe
CRITICAL CARE MEDICINE
(2019)
Article
Endocrinology & Metabolism
Pavel Yanev, Katherine Poinsatte, Devon Hominick, Noor Khurana, Kielen R. Zuurbier, Marcus Berndt, Erik J. Plautz, Michael T. Dellinger, Ann M. Stowe
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Article
Medicine, Research & Experimental
Amanda N. Szabo-Reed, Eric Vidoni, Ellen F. Binder, Jeffrey Burns, C. Munro Cullum, William P. Gahan, Aditi Gupta, Linda S. Hynan, Diana R. Kerwin, Heidi Rossetti, Ann M. Stowe, Wanpen Vongpatanasin, David C. Zhu, Rong Zhang, Jeffrey N. Keller
CONTEMPORARY CLINICAL TRIALS
(2019)
Article
Endocrinology & Metabolism
Uma Maheswari Selvaraj, Kielen R. Zuurbier, Cody W. Whoolery, Erik J. Plautz, Ken L. Chambliss, Xiangmei Kong, Shanrong Zhang, Sung Hoon Kim, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Chieko Mineo, Philip W. Shaul, Ann M. Stowe
Article
Medicine, Research & Experimental
Uma Maheswari Selvaraj, Ann M. Stowe
DISCOVERY MEDICINE
(2017)
Article
Clinical Neurology
Erik J. Plautz, Scott Barbay, Shawn B. Frost, Elena V. Zoubina, Ann M. Stowe, Numa Dancause, Ines Eisner-Janowicz, Scott D. Bury, Michael D. Taylor, Randolph J. Nudo
NEUROREHABILITATION AND NEURAL REPAIR
(2016)