Drug repurposing for Alzheimer’s disease based on transcriptional profiling of human iPSC-derived cortical neurons
出版年份 2019 全文链接
标题
Drug repurposing for Alzheimer’s disease based on transcriptional profiling of human iPSC-derived cortical neurons
作者
关键词
-
出版物
Translational Psychiatry
Volume 9, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-09-06
DOI
10.1038/s41398-019-0555-x
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
- (2018) Ben Readhead et al. NEURON
- Estriol-mediated neuroprotection in multiple sclerosis localized by voxel-based morphometry
- (2018) Allan MacKenzie-Graham et al. Brain and Behavior
- Harnessing Genetic Complexity to Enhance Translatability of Alzheimer’s Disease Mouse Models: A Path toward Precision Medicine
- (2018) Sarah M. Neuner et al. NEURON
- A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology
- (2018) Mikael Marttinen et al. NEUROBIOLOGY OF DISEASE
- Targeting acute myeloid leukemia by drug-induced c-MYB degradation
- (2017) V Walf-Vorderwülbecke et al. LEUKEMIA
- Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry
- (2017) Hon-Cheong So et al. NATURE NEUROSCIENCE
- Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist
- (2017) Pooneh Memar Ardestani et al. NEUROPHARMACOLOGY
- β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
- (2017) Shuchi Mittal et al. SCIENCE
- Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation
- (2017) Anna Ochalek et al. Alzheimers Research & Therapy
- Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity
- (2017) Renchao Chen et al. Cell Reports
- Mitochondrial Transcription Factor A (TFAM) Gene Variation and Risk of Late-Onset Alzheimer's Disease
- (2017) Victoria Alvarez et al. JOURNAL OF ALZHEIMERS DISEASE
- Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
- (2017) Erika Castillo et al. Scientific Reports
- Neuroprotection by Chlorpromazine and Promethazine in Severe Transient and Permanent Ischemic Stroke
- (2016) Xiaokun Geng et al. MOLECULAR NEUROBIOLOGY
- The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function
- (2016) Samuel E. Marsh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ToxDB: pathway-level interpretation of drug-treatment data
- (2016) C. Hardt et al. Database-The Journal of Biological Databases and Curation
- Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease
- (2016) Minghui Wang et al. Genome Medicine
- A Combination of Neostigmine and Anisodamine Protects against Ischemic Stroke by Activating α7nAChR
- (2015) Jiao Qian et al. International Journal of Stroke
- Pinacidil and levamisole prevent glutamate-induced death of hippocampal neuronal cells through reducing ROS production
- (2015) Mustafa Shukry et al. NEUROLOGICAL RESEARCH
- Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
- (2015) A. Zeisel et al. SCIENCE
- Limited Effects of aneIF2αS51AAllele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease
- (2015) Katharina Paesler et al. NEURAL PLASTICITY
- DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes
- (2015) Peter Sykora et al. NUCLEIC ACIDS RESEARCH
- Phenoxybenzamine Is Neuroprotective in a Rat Model of Severe Traumatic Brain Injury
- (2014) Thomas Rau et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
- (2014) Y. Zhang et al. JOURNAL OF NEUROSCIENCE
- Neuroprotection of posttreatment with risperidone, an atypical antipsychotic drug, in rat and gerbil models of ischemic stroke and the maintenance of antioxidants in a gerbil model of ischemic stroke
- (2014) Bing Chun Yan et al. JOURNAL OF NEUROSCIENCE RESEARCH
- SPIEDw: a searchable platform-independent expression database web tool
- (2013) Gareth Williams BMC GENOMICS
- Transcriptional Regulation and Its Misregulation in Disease
- (2013) Tong Ihn Lee et al. CELL
- Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
- (2013) Takayuki Kondo et al. Cell Stem Cell
- Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study
- (2013) Masaaki Hokama et al. CEREBRAL CORTEX
- Probenecid: An Emerging Tool for Neuroprotection
- (2013) Ana Colín-González et al. CNS & Neurological Disorders-Drug Targets
- Effects of allantoin on cognitive function and hippocampal neurogenesis
- (2013) Young Je Ahn et al. FOOD AND CHEMICAL TOXICOLOGY
- The Genotype-Tissue Expression (GTEx) project
- (2013) John Lonsdale et al. NATURE GENETICS
- A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer's disease
- (2013) Anna Antonell et al. NEUROBIOLOGY OF AGING
- Genes and pathways underlying regional and cell type changes in Alzheimer's disease
- (2013) Jeremy A Miller et al. Genome Medicine
- A searchable cross-platform gene expression database reveals connections between drug treatments and disease
- (2012) Gareth Williams BMC GENOMICS
- Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice
- (2012) Amit Berson et al. EMBO Molecular Medicine
- Time dependent neuroprotection of mycophenolate mofetil: effects on temporal dynamics in glial proliferation, apoptosis, and scar formation
- (2012) Fahim Ebrahimi et al. Journal of Neuroinflammation
- Transcriptional Alterations Related to Neuropathology and Clinical Manifestation of Alzheimer’s Disease
- (2012) Aderbal R. T. Silva et al. PLoS One
- Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells
- (2012) N. Egawa et al. Science Translational Medicine
- The Human Brain in a Dish: The Promise of iPSC-Derived Neurons
- (2011) Ricardo Dolmetsch et al. CELL
- mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass
- (2011) Steven D. Kunkel et al. Cell Metabolism
- Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease
- (2011) Eric M. Blalock et al. JOURNAL OF CHEMICAL NEUROANATOMY
- Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer
- (2011) Mehrdad Faizi et al. NEUROBIOLOGY OF DISEASE
- Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease
- (2011) J. T. Dudley et al. Science Translational Medicine
- Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data
- (2011) M. Sirota et al. Science Translational Medicine
- Amelioration of Inflammation and Cytotoxicity by Dipyridamole in Brain Endothelial Cells
- (2010) Shuzhen Guo et al. CEREBROVASCULAR DISEASES
- Evaluation of Phenoxybenzamine in the CFA Model of Pain following Gene Expression Studies and Connectivity Mapping
- (2010) Meiping Chang et al. Molecular Pain
- Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort
- (2010) Anita Lakatos et al. NEUROBIOLOGY OF AGING
- Identification of select glucocorticoids as Smoothened agonists: Potential utility for regenerative medicine
- (2010) J. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic Control of Human Brain Transcript Expression in Alzheimer Disease
- (2009) Jennifer A. Webster et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
- (2009) Paula I. Moreira et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Neuroprotective effects of probenecid in a transgenic animal model of Huntington’s disease
- (2009) Eniko Vamos et al. JOURNAL OF NEURAL TRANSMISSION
- Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models
- (2009) Sandra Pereson et al. JOURNAL OF PATHOLOGY
- Kavalactones Protect Neural Cells against Amyloid Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation
- (2008) C. J. Wruck et al. MOLECULAR PHARMACOLOGY
- Gene network dynamics controlling keratinocyte migration
- (2008) Hauke Busch et al. Molecular Systems Biology
- Gene expression changes in the course of normal brain aging are sexually dimorphic
- (2008) N. C. Berchtold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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