Article
Biochemistry & Molecular Biology
Hui-Hui Wang, Ya-Nan Sun, Tai-Qi Qu, Xue-Qin Sang, Li-Mian Zhou, Yi-Xuan Li, Fa-Zheng Ren
Summary: This study found that nobiletin (Nob) can delay skeletal muscle aging by improving mitochondrial function and autophagy function, reducing reactive oxygen species production and inflammation, inhibiting cell apoptosis and aging, thereby improving skeletal muscle degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Elizabeth M. Connelly, Karling S. Frankel, Gary S. Shaw
Summary: Aging, toxic chemicals, and changes to cellular environment cause oxidative damage to mitochondria, contributing to neurodegenerative diseases like Parkinson's. To maintain homeostasis, cells use signaling mechanisms involving PINK1 and parkin to identify and remove damaged proteins and mitochondria. PINK1 phosphorylates ubiquitin on mitochondrial proteins in response to oxidative stress, leading to parkin translocation, further phosphorylation, and ubiquitination of outer mitochondrial membrane proteins. This ubiquitination is crucial in targeting proteins for degradation or eliminating the whole organelle via mitophagy.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Angie. K. K. Torres, Claudia Jara, Jesus Llanquinao, Matias Lira, Daniela Cortes-Diaz, Cheril Tapia-Rojas
Summary: Aging is a physiological process that leads to progressive decline in cellular functions. Mitochondrial dysfunction has been identified as a significant factor in aging, and specifically, the hippocampal mitochondria in aged female mice were found to exhibit various impairments in this study. These impairments include decreased bioenergetic function, increased ROS production, deregulation of calcium homeostasis, and disturbances in mitochondrial dynamics and quality control processes. These findings suggest that the accumulation of damaged mitochondria may contribute to the aging phenotype and age-related disabilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Shu-ping Yang, Qing Su, Ya-ru Zhang, Yun Sun, Yu-rong Chai
Summary: Metformin has a therapeutic effect on thymus degeneration by improving mitochondrial function, alleviating thymus atrophy caused by D-galactose, altering T lymphocyte subsets and cellular senescent cells, and increasing the expression of specific genes in thymic epithelial cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Taichi Fukunaga, Shuuichi Mori, Takuya Omura, Yoshihiro Noda, Yasunori Fujita, Ikuroh Ohsawa, Kazuhiro Shigemoto
Summary: Mitochondrial dysfunction is considered a major cause of sarcopenia, and its effects differ based on fiber type. Oxidative stress is associated with age-related muscle fiber atrophy, while specific mitochondrial changes may correlate with muscle quality rather than muscle mass.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Mariana Pires, Ana Cristina Rego
Summary: APOE epsilon 4 allele (ApoE4) is the primary genetic risk factor for sporadic Alzheimer's disease (AD), associated with cognitive impairment and neurodegeneration. ApoE4 impacts mitochondrial function, increases reactive oxygen species (ROS) and calcium levels, affects mitochondrial dynamics and translocates to the nucleus to regulate gene expression related to aging, amyloid-beta production, inflammation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Christie M. Penniman, Gourav Bhardwaj, Colette J. Nowers, Chandler U. Brown, Taylor L. Junck, Cierra K. Boyer, Jayashree Jena, Jordan D. Fuqua, Vitor A. Lira, Brian T. O'Neill
Summary: This study investigates the role of FoxOs in regulating muscle strength and mitochondrial function with age. The results show that deletion of FoxOs increases muscle strength and improves mitochondrial function in both young and aged mice. This is partly due to the suppression of atrophic pathways and the maintenance of OXPHOS.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Immunology
Catherine M. Jankowski, Melissa P. Wilson, Samantha MaWhinney, Jane Reusch, Leslie Knaub, Sara Hull, Kristine M. Erlandson
Summary: The study found that individuals with HIV had blunted mitochondrial adaptations to exercise compared to uninfected controls, suggesting the need for different types of exercise-induced stimulation to improve mitochondrial function in this population.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Yan Gong, Yuanfei Luo, Suqin Liu, Jipeng Ma, Fangpeng Liu, Yan Fang, Feng Cao, Lin Wang, Zhaohui Pei, Jun Ren
Summary: This study demonstrates the beneficial role of oleanolic acid (OA) in attenuating cardiac remodeling and contractile dysfunction in aging through a FUNDC1-mediated mechanism, involving regulation of mitochondrial integrity and mitophagy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Cell Biology
Debora F. Goncalves, Tamie Duarte, Joao V. P. Foletto, Leahn R. Senger, Nilda B. V. Brabosa, Felix A. A. Soares, Cristiane L. Dalla Corte
Summary: Parkinson's disease is a common neurodegenerative disease characterized by movement disorders and loss of dopaminergic neurons. Mitochondrial dysfunction and cellular energy imbalance are common markers found in PD. This study used a fruit fly model to investigate the changes in energetic pathways and mitochondrial functions during aging in a PD model.
Review
Cell Biology
Lei Liu, Yanjun Li, Guo Chen, Quan Chen
Summary: Mitochondrial biogenesis and mitophagy are essential mechanisms for cellular energy regulation, and their coordinated regulation plays a crucial role in maintaining cellular homeostasis under physiological and pathophysiological conditions.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Nutrition & Dietetics
Hyemin Min, Esther Youn, Yhong-Hee Shim
Summary: This study suggests that long-term intake of caffeine may have anti-aging effects on the intestine by suppressing ACT-5 mislocalization, reducing autophagy, improving mitochondrial function, and increasing antioxidant capacity.
Article
Cell Biology
Olena Odnokoz, Kyle Nakatsuka, Corbin Wright, Jovelyn Castellanos, Vladimir Klichko, Doris Kretzschmar, William C. Orr, Svetlana N. Radyuk
Summary: Mitochondrial dysfunction is closely related to oxidative stress and is considered a major factor in the development of neurological disorders. The under-expression of mitochondrial Prxs in flies may lead to behavioral changes associated with neural function and affect lifespan and motor activity, suggesting a causal link between mitochondrial Prx activity and the development of neurological disorders and premature aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yafei Jiao, Yixian Wang, Tiantuan Jiang, Keying Wen, Peiqing Cong, Yaosheng Chen, Zuyong He
Summary: Quercetin has been found to improve the in vitro maturation rate of porcine oocytes, reduce aging, and protect against oxidative stress by maintaining mitochondrial function and regulating gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guiping Chen, Ling Zeng, Feng Yan, Jinlong Liu, Mengqi Qin, Feifei Wang, Xu Zhang
Summary: Naringenin improves visual function and retinal structure in aging mouse retinas by influencing mitochondrial dynamics and autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Luis Alberto Luevano-Martinez, Maria Fernanda Forni, Julia Peloggia, Ii-Sei Watanabe, Alicia J. Kowaltowski
MECHANISMS OF AGEING AND DEVELOPMENT
(2017)
Article
Cell Biology
Maria Fernanda Forni, Julia Peloggia, Tarcio T. Braga, Jesus Eduardo Ortega Chinchilla, Jorge Shinohara, Carlos Arturo Navas, Niels Olsen Saraiva Camara, Alicia J. Kowaltowski
Review
Developmental Biology
Thais Assis-Ribas, Maria Fernanda Forni, Sheila Maria Brochado Winnischofer, Mari Cleide Sogayar, Marina Trombetta-Lima
DEVELOPMENTAL BIOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Marilene Demasi, Fernanda Marques da Cunha
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2018)
Article
Endocrinology & Metabolism
Caroline A. P. de Souza, Camila Congentino Gallo, Ludmilla Scodeler de Camargo, Paula Vargas Versignassi de Carvalho, Ingrid Fernandes Olescuck, Felipe Macedo, Fernanda Marques da Cunha, Jose Cipolla-Neto, Fernanda G. do Amaral
JOURNAL OF PINEAL RESEARCH
(2019)
Review
Neurosciences
Felipe Macedo, Lucas Souza dos Santos, Isaias Glezer, Femanda Marques da Cunha
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Felipe Macedo, Gabriel Loureiro Martins, Luis A. Luevano-Martinez, Gustavo Monteiro Viana, Karin A. Riske, Alex Inague, Marcos Y. Yoshinaga, Hugo Aguilaniu, Sayuri Miyamoto, Isaias Glezer, Fernanda Marques da Cunha
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Article
Geriatrics & Gerontology
Vittoria de Lima Camandona, Rafaela Maria Rios-Anjos, Thiago Geronimo Pires Alegria, Fabio Pereira, Renata Naporano Bicev, Fernanda Marques da Cunha, Luciano Antonio Digiampietri, Mario Henrique de Barros, Luis Eduardo Soares Netto, Jose Ribamar Ferreira-Junior
Article
Biochemistry & Molecular Biology
Felipe Macedo, Talita Romanatto, Carolina Gomes de Assis, Alexia Buis, Alicia J. Kowaltowski, Hugo Aguilaniu, Fernanda Marques da Cunha
Article
Cell Biology
Tamara Silva Rodrigues, Annie Rocio Pineros Alvarez, Ana Flavia Gembre, Maria Fernanda Pereira de Araujo Demonte Forni, Bruno Marcel Silva de Melo, Jose Carlos Farias Alves Filho, Niels Olsen Saraiva Camara, Vania Luiza Deperon Bonato
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Chemistry, Analytical
Carla S. Santos, Felipe Macedo, Alicia J. Kowaltowski, Mauro Bertotti, Patrick R. Unwin, Fernanda Marques da Cunha, Gabriel N. Meloni
Summary: By using scanning electrochemical microscopy (SECM) to measure the localized oxygen consumption rates (OCRs) in different regions of single adult Caenorhabditis elegans individuals, this study revealed marked heterogeneity of OCR along the worm, with high respiration rates at the reproductive system region. Through a self-referencing approach and genetic/pharmacological methods, SECM measurements indicate that viable eggs in the reproductive system are the main contributors to the total oxygen consumption of adult Caenorhabditis elegans, providing new insights into tissue-specific metabolic analyses and toxicity evaluation within single organisms.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Marilene Demasi, Ohara Augusto, Etelvino J. H. Bechara, Renata N. Bicev, Fernanda M. Cerqueira, Fernanda M. da Cunha, Ana Denicola, Fernando Gomes, Sayuri Miyamoto, Luis E. S. Netto, Lia M. Randall, Cassius V. Stevani, Leonor Thomson
Summary: Research on protein oxidation began in 1980, exploring the impact of oxidative modifications on protein function and cellular homeostasis. Recent studies have shown that not all oxidative modifications result in damage, but can also alter protein structure and function. Understanding the effects of protein oxidation on human pathological conditions is clinically significant.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Oncology
Maria Fernanda Forni, Omar Alberto Dominguez-Amoroch, Leonardo Vinicius Monteiro de Assis, Gabriela Sarti Kinker, Maria Nathalia Moraes, Ana Maria de Lauro Castrucci, Niels Olsen Saraiva Camara
Summary: The TRPA1 channel plays a significant role in the immune response against melanoma tumor progression, with its absence leading to a significant reduction in tumor growth and correlation with immune pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Cristiane Naffah de Souza Breda, Leandro Carvalho Dantas Breda, Larissa Anastacio da Costa Carvalho, Mariane Tami Amano, Fernanda Fernandes Terra, Reinaldo Correia Silva, Matheus Garcia Fragas, Maria Fernanda Forni, Monique Thais Costa Fonseca, Gabriela Venturini, Amanda Campelo Melo Feitosa, Bruno Ghirotto, Mario Costa Cruz, Flavia Franco Cunha, Aline Ignacio, Marcela Latancia, Angela Castoldi, Vinicius Andrade-Oliveira, Eloisa Martins da Silva, Meire Ioshie Hiyane, Alexandre da Costa Pereira, William Festuccia, Flavia Carla Meotti, Niels Olsen Saraiva Camara
Summary: This study found that the loss of Rictor in primary mouse-derived neutrophils affects chemotaxis and microbial killing capacity, but not phagocytic capacity. The impaired microbicidal capacity in Rictor-deleted neutrophils was attributed to improper granule fusion and reduced hypochlorous acid production. Furthermore, Rictor deletion led to metabolic alterations in neutrophils, increasing aerobic glycolysis. Overall, the study highlights the importance of proper mTORC2 activation for neutrophil effector functions and metabolism during sepsis.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Renata Naporano Bicev, Maximilia Frazao de Souza Degenhardt, Cristiano Luis Pinto de Oliveira, Emerson Rodrigo da Silva, Jeril Degrouard, Guillaume Tresset, Graziella Eliza Ronsein, Marilene Demasi, Fernanda Marques da Cunha
Summary: Glucose restriction enhances the activity of proteasomes in yeast cells, improving their ability to degrade proteins, possibly through phosphorylation of the proteasome subunit. However, this enhancement in activity does not result from changes in the conformation of the proteasome particles.
SCIENTIFIC REPORTS
(2023)