Article
Biochemistry & Molecular Biology
Ching-Fang Chang, Amanda L. Gunawan, Irene Liparulo, Peter-James H. Zushin, Ambre M. Bertholet, Yuriy Kirichok, Andreas Stahl
Summary: Coenzyme Q deficiency affects respiration in brown adipose tissue by regulating UCP1 expression, leading to increased mitochondrial membrane potential and decreased ADP/ATP ratios. This deficiency also enhances cold sensitivity.
Article
Medicine, Research & Experimental
Jian Yu, Xin Chen, Yuanjin Zhang, Xiangdi Cui, Zhe Zhang, Wenxiu Guo, Dongmei Wang, Shengbo Huang, Yanru Chen, Yepeng Hu, Cheng Zhao, Jin Qiu, Yu Li, Meiyao Meng, Mingwei Guo, Fei Shen, Mengdi Zhang, Ben Zhou, Xuejiang Gu, Jiqiu Wang, Xin Wang, Xinran Ma, Lingyan Xu
Summary: This study demonstrates that azithromycin, a type of macrolide antibiotics, inhibits the functionality of brown and beige adipocytes. Azithromycin accumulates in adipose tissue of obese patients and is associated with BMI and body weight. The antibiotic impairs mitochondrial function in brown and beige adipocytes through inhibiting mitochondrial respiratory complex I and increasing ROS levels.
Review
Endocrinology & Metabolism
Andre C. Carpentier, Denis P. Blondin, Francois Haman, Denis Richard
Summary: Brown adipose tissue (BAT) is an important therapeutic target for cardiometabolic diseases due to its unique ability to generate heat. The current definition and measurement of BAT relies on glucose uptake observation, which may not accurately assess BAT's thermogenic activity. The main energy substrate for BAT thermogenesis is intracellular fatty acids, and the response is interconnected with that of white adipose tissue and other metabolic tissues. Current drugs are unable to independently stimulate BAT's thermogenic response.
Review
Endocrinology & Metabolism
Ruping Pan, Yong Chen
Summary: Obesity is characterized by the overaccumulation of white adipose tissue in the body, leading to various metabolic disorders. Targeting human thermogenic adipose tissues shows promise in combating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Jamie I. van der Vaart, Mariette R. Boon, Riekelt H. Houtkooper
Summary: Obesity is on the rise and research is focusing on new ways to combat it, with a particular interest in targeting brown adipose tissue (BAT) and AMPK to increase energy expenditure and regulate energy balance. AMPK can be activated by various kinases, hormones, and metabolic stresses to activate BAT, but further research is needed before using it as a target for anti-obesity treatment.
Review
Endocrinology & Metabolism
Okamatsu-Ogura Yuko, Masayuki Saito
Summary: The article provides an overview of brown adipose tissue (BAT), including its functions in health and diseases, the development of inducible thermogenic adipocytes (beige adipocytes), the diversity of thermogenic mechanisms, and BAT's influence on peripheral tissues and systemic homeostasis.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Medicine, Research & Experimental
Caroline Mendes, Guilherme Gomes, Luciana Tocci Belpiede, Daniella do Carmo Buonfiglio, Livia Clemente Motta-Teixeira, Fernanda Gaspar Amaral, Jose Cipolla-Neto
Summary: The study shows that chronic melatonin supplementation can increase the animal's thermogenic potential in cold environments, promoting the coordinated action of brown and beige adipocytes to ensure adequate heat production.
Review
Medicine, Research & Experimental
Amira Mohamed Taha, Abdelrahman Mohamed Mahmoud, Mohamed M. Ghonaim, Ateeba Kamran, Jehad Feras Alsamhori, Majd M. Albarakat, Abhigan Babu Shrestha, Vikash Jaiswal, Russel J. Reiter
Summary: Septic cardiomyopathy is a complication of sepsis with high mortality rates. Despite extensive research, there is currently no effective pharmacological agent for this condition. Melatonin, with its diverse functions in the body, has emerged as a potential treatment for sepsis-induced cardiomyopathy due to its anti-oxidant, anti-inflammatory, anti-apoptotic, and cardioprotective roles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Kuiliang Zhang, Juan Sun, Mingcong Fan, Haifeng Qian, Hao Ying, Yan Li, Li Wang
Summary: Activation and recruitment of brown adipose tissue are effective for treating obesity and related diseases. Functional ingredients in wholegrains positively affect the activity of brown adipocytes and browning of white adipocytes, contributing to the control of obesity and energy metabolism.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Geriatrics & Gerontology
Karin J. C. Sanders, Roel Wierts, Wouter D. Marken Lichtenbelt, Judith Vos-Geelen, Guy Plasqui, Marco C. J. M. Kelders, Vera B. Schrauwen-Hinderling, Jan Bucerius, Anne-Marie C. Dingemans, Felix M. Mottaghy, Annemie M. W. J. Schols
Summary: There is no correlation between basal metabolic rate (BMR), total daily energy expenditure (TDEE), and brown adipose tissue (BAT) activity in patients with chronic obstructive pulmonary disease (COPD). Additionally, BAT activity and gene expression levels of brown adipocyte or beige markers are comparable between COPD patients and controls.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Multidisciplinary Sciences
Takahiro Seki, Yunlong Yang, Xiaoting Sun, Sharon Lim, Sisi Xie, Ziheng Guo, Wenjing Xiong, Masashi Kuroda, Hiroshi Sakaue, Kayoko Hosaka, Xu Jing, Masahito Yoshihara, Lili Qu, Xin Li, Yuguo Chen, Yihai Cao
Summary: Exposure to cold conditions inhibits the growth of various types of solid tumors by decreasing blood glucose and impeding glycolysis-based metabolism in cancer cells. Cold exposure also reduces glucose uptake in tumor tissue. These findings provide a new concept and paradigm for cancer therapy using a simple and effective approach.
Article
Cell Biology
Alba Sabate-Perez, Montserrat Romero, Paula Sanchez-Fernandez-de-Landa, Stefania Carobbio, Michail Mouratidis, David Sala, Pablo Engel, Josep A. Villena, Sam Virtue, Antonio Vidal-Puig, Manuel Palacin, Xavier Testar, Antonio Zorzano
Summary: The study reveals a novel molecular mechanism by which TP53INP2 regulates PPARG activity and brown adipogenesis through autophagy, and demonstrates the importance of TP53INP2 in maintaining thermogenic capacity and preventing lipid accumulation in brown adipose tissue. These findings provide insights into the therapeutic strategies against obesity and its metabolic complications.
Article
Biochemistry & Molecular Biology
Katalin Gyurina, Mariia Yarmak, Laszlo Sasi-Szabo, Sarolta Molnar, Gabor Mehes, Tamas Roeszer
Summary: Studying subcutaneous adipose tissues in fetuses, infants, and children, we found that UCP1-positive adipocytes are mainly located in the deep layer of adipose tissue, particularly in the abdominal wall. These UCP1-positive adipocytes develop in late fetal stage and persist throughout childhood, expressing genes related to mitochondrial biogenesis and thermogenesis. The absence of UCP1 expression in adipose tissue during the early childhood adiposity rebound phase is associated with an obesity-related gene expression signature. UCP1 expression is negatively correlated with BMI z-score and adipocyte size in infants and children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Tao Zhu, Xu Chen, Shenglu Jiang
Summary: Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have been studied for their potential in improving obesity and metabolic disorders. However, the whitening of the brown fat graft and impaired metabolic function are significant challenges. This review discusses specific experiment designs, graft outcomes, and metabolic benefits, providing guidance for further investigation and innovation in BAT transplantation methods.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Yan Meng, Zhengbo Tao, Siming Zhou, Wacili Da, Lin Tao
Summary: This study conducted a quantitative and qualitative analysis of melatonin research over the past 20 years using bibliometric methods, predicting future research trends. Findings showed that the United States had the highest number of publications in melatonin research, and future research hot spots are likely to focus on the structure and function of melatonin, clinical applications, and target-based drug design.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Analytical
Carla S. Santos, Felipe Macedo, Alicia J. Kowaltowski, Mauro Bertotti, Patrick R. Unwin, Fernanda Marques da Cunha, Gabriel N. Meloni
Summary: By using scanning electrochemical microscopy (SECM) to measure the localized oxygen consumption rates (OCRs) in different regions of single adult Caenorhabditis elegans individuals, this study revealed marked heterogeneity of OCR along the worm, with high respiration rates at the reproductive system region. Through a self-referencing approach and genetic/pharmacological methods, SECM measurements indicate that viable eggs in the reproductive system are the main contributors to the total oxygen consumption of adult Caenorhabditis elegans, providing new insights into tissue-specific metabolic analyses and toxicity evaluation within single organisms.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Marilene Demasi, Ohara Augusto, Etelvino J. H. Bechara, Renata N. Bicev, Fernanda M. Cerqueira, Fernanda M. da Cunha, Ana Denicola, Fernando Gomes, Sayuri Miyamoto, Luis E. S. Netto, Lia M. Randall, Cassius V. Stevani, Leonor Thomson
Summary: Research on protein oxidation began in 1980, exploring the impact of oxidative modifications on protein function and cellular homeostasis. Recent studies have shown that not all oxidative modifications result in damage, but can also alter protein structure and function. Understanding the effects of protein oxidation on human pathological conditions is clinically significant.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Endocrinology & Metabolism
Jose Cipolla-Neto, Fernanda Gaspar Amaral, Jose Maria Soares-Jr, Camila Congentino Gallo, Andre Furtado, Jose Eduardo Cavaco, Isabel Goncalves, Cecilia Reis Alves Santos, Telma Quintela
Summary: This study reviews the various effects of melatonin on biological functions, discusses the interactions between melatonin and sex hormones, and highlights the impact of melatonin on female gonadal steroidogenesis and hormonal control. It suggests that there is ambiguity in the influence of sex differences on the circadian rhythms of melatonin, and the debate surrounding the reciprocal relationship between melatonin and reproductive hormones remains inconclusive.
NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Elaine C. Marqueze, Luciana F. R. Nogueira, Celine Vetter, Debra J. Skene, Jose Cipolla-Neto, Claudia R. C. Moreno
Summary: Shift workers often face chronic circadian misalignment, with early types experiencing greater misalignment during night shifts. Melatonin supplementation has shown to reduce circadian misalignment and body weight in early chronotypes, without affecting calorie intake or physical activity levels, according to a recent study on overweight female nurses.
JOURNAL OF PINEAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Klausen Oliveira-Abreu, Jose Cipolla-Neto, Jose Henrique Leal-Cardoso
Summary: Studies suggest that melatonin (MEL) has therapeutic potential as an adjunct treatment for neural complications of diabetes mellitus (DM). However, variations in dosage, treatment duration, and treatment timing hinder objective analysis of the progress and establishment of parameters for the validation of MEL in the treatment of neural complications of DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Luisa K. Pilz, Natividade S. Couto Pereira, Ana Paula Francisco, Alicia Carissimi, Debora B. Constantino, Leticia B. Caus, Ana Carolina O. Abreu, Guilherme R. Amando, Fernanda S. Bonatto, Paula V. V. Carvalho, Jose Cipolla-Neto, Ana Harb, Gabriela Lazzarotto, Joseane Righes Marafiga, Luciano Minuzzi, Francisco Montagner, Fernanda A. Nishino, Melissa A. B. Oliveira, Bruno G. T. dos Santos, Eduardo G. Steibel, Patrice S. Tavares, Andre C. Tonon, Nicoli B. Xavier, Querusche Klippel Zanona, Fernanda G. Amaral, Maria Elisa Calcagnotto, Benicio N. Frey, Maria Paz Hidalgo, Marco Idiart, Thais Russomano
Summary: This study assessed the adherence to evidence-based recommendations for supporting mental health during the COVID-19 pandemic and its association with depressive and anxiety symptoms. The results showed that adherence to the recommendations was significantly associated with reduced anxiety and depression symptoms. The recommendations developed in this study could be important for preventing negative mental health effects during and beyond the pandemic.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Ribeiro Valias, Patricia Rodrigues Lourenco Gomes, Fernanda G. Amaral, Saif Alnuaimi, Daniela Monteiro, Siobhan O'Sullivan, Renato Zangaro, Jose Cipolla-Neto, Juan Acuna, Ovidiu Constantin Baltatu, Luciana Aparecida Campos
Summary: This observational clinical study suggests that urinary levels of angiotensinogen may be altered in preeclampsia and gestational diabetes, while melatonin production may be defective in gestational diabetes and hypertension. An angiotensinogen/melatonin ratio is suggested as an early biomarker for identification of gestational diabetes or hypertension.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Nutrition & Dietetics
Luciana Fidalgo Ramos Nogueira, Cibele Aparecida Crispim, Jose Cipolla-Neto, Claudia Roberta de Castro Moreno, Elaine Cristina Marqueze
Summary: This study aimed to evaluate the effects of exogenous melatonin administration on eating habits in female night workers with excessive weight. The results showed that melatonin treatment did not significantly affect the quality, quantity, and timing of food intake. In addition, circadian misalignment and chronotype were not associated with these outcomes.
Article
Biochemistry & Molecular Biology
Luciana Aparecida Campos, Ovidiu Constantin Baltatu, Sergio Senar, Rym Ghimouz, Eman Alefishat, Jose Cipolla-Neto
Summary: This study explores the potential of melatonin as a therapeutic target for comorbid diseases associated with psychosocial-sleep/circadian-cardiometabolic disorders. The association between melatonin receptors and the disorders was investigated using various databases. The study also analyzed melatonin's activity in cardiovascular, neuronal, and metabolic assays. Overall, the research suggests that melatonin could be an important target for treating these disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Neurosciences
Cecilia R. A. Santos, Jose Cipolla-Neto, Markus Krohn, Isabel Goncalves, Telma Quintela
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Lia Alencar Coelho, Luciano Andrade Silva, Ana Paula Reway, Daniella Do Carmo Buonfiglio, Jessica Andrade-Silva, Patricia Rodrigues Lourenco Gomes, Jose Cipolla-Neto
Summary: Reproductive activity in mares shows a seasonal pattern, with more ovulations occurring during the spring and summer seasons. The photoperiodic control of reproduction is mediated by melatonin, which inhibits ovulatory activity. This study investigated the effect of melatonin on mare ovarian follicle development, and found that melatonin upregulates the expression of melatonin receptors and melatonin-forming enzymes, as well as increasing melatonin levels in developing follicles during the reproductive seasons.
Article
Biochemistry & Molecular Biology
Cristiane Lima Roa, Jose Cipolla-Neto, Russel J. Reiter, Iara Moreno Linhares, Ana Paula Lepique, Lana Maria de Aguiar, Isadora Braga Seganfredo, Edson Santos Ferreira-Filho, Sebastiao Freitas de Medeiros, Edmund Chada Baracat, Jose Maria Soares-Jr
Summary: This study aimed to evaluate the action of melatonin, acyclovir, or the combination of melatonin with acyclovir as a suppressive treatment for recurrent genital herpes. The findings suggest that melatonin may be an effective alternative for the suppressive therapy of recurrent genital herpes.
Article
Multidisciplinary Sciences
Renata Naporano Bicev, Maximilia Frazao de Souza Degenhardt, Cristiano Luis Pinto de Oliveira, Emerson Rodrigo da Silva, Jeril Degrouard, Guillaume Tresset, Graziella Eliza Ronsein, Marilene Demasi, Fernanda Marques da Cunha
Summary: Glucose restriction enhances the activity of proteasomes in yeast cells, improving their ability to degrade proteins, possibly through phosphorylation of the proteasome subunit. However, this enhancement in activity does not result from changes in the conformation of the proteasome particles.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Eduardo Carvalho de Arruda Veiga, Ricardo dos Santos Simoes, Leonardo L. Caviola, Luiz Carlos Abreu, Ricardo Carvalho Cavalli, Jose Cipolla-Neto, Edmund Chada Baracat, Jose Maria Soares Junior
Summary: Melatonin has various beneficial effects on the cardiovascular system, including reducing infarct size, improving cardiac function, exhibiting antioxidant properties, and enhancing biometric analyses. The meta-analysis showed a significant decrease in infarct size, lactate dehydrogenase levels, and improvement in cardiac ejection fraction in animals treated with melatonin. Most studies included in the review had a low risk of bias, suggesting melatonin could be a potential therapeutic target for cardiovascular diseases.
