Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex
出版年份 2019 全文链接
标题
Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex
作者
关键词
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出版物
eLife
Volume 8, Issue -, Pages -
出版商
eLife Sciences Publications, Ltd
发表日期
2019-08-22
DOI
10.7554/elife.48630
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
- (2019) Eunhee Choi et al. Nature Communications
- Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor
- (2018) Theresia Gutmann et al. JOURNAL OF CELL BIOLOGY
- How ligand binds to the type 1 insulin-like growth factor receptor
- (2018) Yibin Xu et al. Nature Communications
- Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis
- (2018) Giovanna Scapin et al. NATURE
- The signalling conformation of the insulin receptor ectodomain
- (2018) Felix Weis et al. Nature Communications
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis
- (2016) Eunhee Choi et al. CELL
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- X-ray structure of the human α4β2 nicotinic receptor
- (2016) Claudio L. Morales-Perez et al. NATURE
- Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain
- (2016) Tristan I. Croll et al. STRUCTURE
- Insulin/receptor binding: The last piece of the puzzle?
- (2015) Pierre De Meyts BIOESSAYS
- Atomic structure of the apoptosome: mechanism of cytochromec- and dATP-mediated activation of Apaf-1
- (2015) Mengying Zhou et al. GENES & DEVELOPMENT
- Sampling the conformational space of the catalytic subunit of human γ-secretase
- (2015) Xiao-chen Bai et al. eLife
- Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex fromPseudomonas aeruginosareveal a calcium-dependent membrane-binding mechanism
- (2014) Defen Lu et al. MOLECULAR MICROBIOLOGY
- How IGF-1 activates its receptor
- (2014) Jennifer M Kavran et al. eLife
- Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine
- (2014) Wilson Wong et al. eLife
- How insulin engages its primary binding site on the insulin receptor
- (2013) John G. Menting et al. NATURE
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Prevention of overfitting in cryo-EM structure determination
- (2012) Sjors H W Scheres et al. NATURE METHODS
- A Bayesian View on Cryo-EM Structure Determination
- (2011) Sjors H.W. Scheres JOURNAL OF MOLECULAR BIOLOGY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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