Article
Cell Biology
Sungsoo Kim, Richard Carvajal, Minah Kim, Hee Won Yang
Summary: The combination of BRAF and MEK inhibitors has shown promise in treating BRAF-mutant melanoma, but drug-tolerant persister cells limit treatment efficacy. RTK activation plays a key role in ERK reactivation and persister development.
Article
Plant Sciences
Guowei Gong, Yuzhong Zheng, Xiangpeng Kong, Zhen Wen
Summary: Ononin, a bioactive compound found in functional foods or plants, has been shown to exhibit anticancer properties in both in vitro and in vivo studies. In this study, ononin was also found to inhibit endothelial cell angiogenesis and suppress tumor cell proliferation. The potential role of ononin as a candidate for prevention and treatment of angiogenesis-related diseases was highlighted in this research.
JOURNAL OF NATURAL PRODUCTS
(2021)
Review
Biochemistry & Molecular Biology
Thomas Jung, Maximilian Haist, Michael Kuske, Stephan Grabbe, Matthias Bros
Summary: The advent of MAPK inhibitors and ICI has greatly improved the treatment of metastatic melanoma, with BRAF/MEK inhibitors used for BRAF mutation patients, showing immunomodulatory functions in addition to their antiproliferative effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anwar Shabna, Jayesh Antony, Vinod Vijayakurup, Minakshi Saikia, Vijayasteltar B. Liju, Archana P. Retnakumari, Nisthul A. Amrutha, Vijai V. Alex, Mundanattu Swetha, Sreekumar U. Aiswarya, Somaraj Jannet, Uma Subramanian Unni, Sankar Sundaram, Daisy R. Sherin, Nikhil Ponnoor Anto, Smitha Bava, Sadasivan Chittalakkottu, Sophia Ran, Ruby John Anto
Summary: This article investigates the mechanism of drug resistance in melanoma and the anti-tumor activity of tryptanthrin, a compound from Wrightia tinctoria, in melanoma. The study found that tryptanthrin inhibits melanoma invasion and metastasis by down-regulating MITF-M expression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chuntian Huang, Ruijuan Du, Xuechao Jia, Kangdong Liu, Yan Qiao, Qiong Wu, Ning Yao, Lu Yang, Liting Zhou, Xuejiao Liu, Pu Xiang, Mingxia Xin, Yan Wang, Xiaojie Chen, Dong Joon Kim, Zigang Dong, Xiang Li
Summary: The study revealed that CDK15 plays a pivotal role in colorectal cancer progression by phosphorylating PAK4 to promote tumor growth. The CDK15-PAK4 axis may serve as a novel therapeutic target for colorectal cancer.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Pharmacology & Pharmacy
Qing Rao, Kaiqiang Xie, Krishnapriya M. Varier, Lei Huang, Jingrui Song, Jue Yang, Jianfei Qiu, Yubing Huang, Yan Li, Babu Gajendran, Yanmei Li, Sheng Liu
Summary: In this study, a mikanolide derivative, 3g, was found to exhibit potent antileukemic activity through the Ras/Raf/MEK/ERK pathway. It can arrest the cell cycle, induce apoptosis, and promote DNA and mitochondrial damage, suggesting its potential as a chemotherapeutic agent for leukemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Pui-Kei Wu, Seung-Keun Hong, Jong-In Park
Summary: The study found that RNA interference of mortalin can induce cell death in vemurafenib-resistant B-Raf mutant melanoma cells, and chemical inhibition of MEK1/2 and ERK1/2 can suppress mortalin depletion-induced death. Therefore, mortalin may serve as a potential therapeutic target for BRAFi-resistant BRAF mutant tumors.
Article
Biotechnology & Applied Microbiology
Chunfeng Li, Shumin Liu, Jian Zheng, Yingwei Xue
Summary: The study found that Angelica sinensis polysaccharide (ASP) can alleviate the cytotoxicity of Diosbulbin-B (DB) on hepatocytes by regulating cell cycle and autophagy pathways.
Article
Biochemistry & Molecular Biology
Chin-Chuan Su, Jhe-Wei Lin, Kai-Yao Chang, Cheng-Tien Wu, Shing-Hwa Liu, Kai-Chih Chang, Jui-Ming Liu, Kuan- Lee, Kai-Min Fang, Ya-Wen Chen
Summary: This study investigated the therapeutic effects and molecular mechanisms of docetaxel on human tongue squamous cell carcinoma cells. The results showed that docetaxel induced cytotoxicity and apoptosis in the cells through modulation of mitochondrial, MAPK, and AMPK signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Nicolas Dumaz, Celeste Lebbe
Summary: Recent studies on the regulation of the MAPK pathway have focused on the dominant role of dimers in RAF, MEK, and ERK, leading to the development of allosteric inhibitors targeting these dimers. The primary goal in the development of next-generation RAF, MEK, and ERK inhibitors is to produce molecules with less off-target effects and sustained pathway inhibition.
CURRENT OPINION IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiao Li, Changqun Liu, Xin Zhang, Chen Sun, Jie Ling, Yilan Liu, Yi Zuo, Yuening Cao, Chaozheng Zhang, Tao Jiang, Maolin Wang, Jin Liu, Jun Lu
Summary: Bruceine A has demonstrated promising potential as a chemotherapeutic agent for treating triple-negative breast cancer (TNBC) and suppressing lung metastasis. Its mechanisms include inhibiting cell cycle-related proteins, inducing mitochondrial dysfunction, and repressing invasion and metastasis-related genes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Eunice Cho, Hua Jane Lou, Leena Kuruvilla, David A. Calderwood, Benjamin E. Turk
Summary: This study identifies PPP6C as a crucial phosphatase for MEK in the ERK pathway, which is frequently mutated or downregulated in melanoma. Loss of PPP6C leads to hyperphosphorylation of MEK, enhancing signaling through the pathway and reducing sensitivity to MEK inhibitors. Its recurrent mutations in melanoma cause MEK hyperphosphorylation, suggesting their role in promoting the disease by activating the core oncogenic pathway.
Article
Biochemistry & Molecular Biology
Maria Victoria Castro, Gaston Alexis Barbero, Paula Mascolo, Rocio Ramos, Maria Josefina Quezada, Pablo Lopez-Bergami
Summary: This study reveals that ROR2 contributes to the progression of melanoma by inhibiting apoptosis and increasing chemoresistance. These findings not only position ROR2 as a marker of chemoresistance but also support its use as a novel therapeutic target in cancer.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Cell Biology
Shuo Han, Xue Li, Ke Wang, Dingheng Zhu, Bingyao Meng, Jieyu Liu, Xiaoting Liang, Yi Jin, Xingyuan Liu, Qian Wen, Liang Zhou
Summary: The study identified a long noncoding RNA called PURPL as an oncogene in melanoma cells, promoting cell proliferation and migration while inhibiting autophagic cell death by modulating the activity of the autophagy initiation factor ULK1. This suggests that targeting PURPL could be a potential intervention strategy for melanoma therapy.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Rahim Ullah, Qing Yin, Aidan H. Snell, Lixin Wan
Summary: The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway that plays a critical role in cell proliferation and survival. Genetic alterations in this pathway are highly prevalent in human cancers and can lead to uncontrolled cell growth and tumor formation. The crosstalk between the RAF-MEK-ERK axis and other signaling pathways further enhances its proliferative potential in human cancers.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)