Mortalin depletion induces MEK/ERK-dependent and ANT/CypD-mediated death in vemurafenib-resistant B-RafV600E melanoma cells

Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability

(2020) Pui-Kei Wu et al.   ONCOGENE

Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability

(2020) Pui-Kei Wu et al.   Science Signaling

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore

(2019) Maria A. Neginskaya et al.   Cell Reports

SPG7 targets the m-AAA protease complex to process MCU for uniporter assembly, Ca2+ influx, and regulation of mPTP opening

(2019) Stephen Hurst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Current for the Mitochondrial Permeability Transition

(2019) Massimo Bonora et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Convergence-Based Framework for Cancer Drug Resistance

(2018) David J. Konieczkowski et al.   CANCER CELL

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

(2018) Andrew M. Kidger et al.   PHARMACOLOGY & THERAPEUTICS

Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells

(2017) Pui-Kei Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch

(2017) Xiangjun Kong et al.   NATURE

Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treatment of cutaneous melanomas

(2017) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relevance of mortalin to cancer cell stemness and cancer therapy

(2017) Chae-Ok Yun et al.   Scientific Reports

Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis

(2016) Y. Na et al.   CANCER RESEARCH

The ERK cascade inhibitors: Towards overcoming resistance

(2016) Galia Maik-Rachline et al.   DRUG RESISTANCE UPDATES

Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction

(2015) Gatien Moriceau et al.   CANCER CELL

Sp1 regulates Raf/MEK/ERK-induced p21CIP1 transcription in TP53-mutated cancer cells

(2015) Mansi Karkhanis et al.   CELLULAR SIGNALLING

Intrinsic and acquired resistance to MEK1/2 inhibitors in cancer

(2014) Matthew J. Sale et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular Pathways: BRAF Induces Bioenergetic Adaptation by Attenuating Oxidative Phosphorylation

(2014) R. Haq et al.   CLINICAL CANCER RESEARCH

Mitochondrial ion channels as oncological targets

(2014) L Leanza et al.   ONCOGENE

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer

(2013) Perri Rozenberg et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition

(2013) JING CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Mortalin/HSPA9-Mediated Switch in Tumor-Suppressive Signaling of Raf/MEK/Extracellular Signal-Regulated Kinase

(2013) P.-K. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

MAP kinase signaling and inhibition in melanoma

(2012) R J Sullivan et al.   ONCOGENE

Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma

(2012) Maria R. Girotti et al.   Cancer Discovery

Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism

(2010) Arnaud Chevrollier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Noncatalytic Function of ERK1/2 Can Promote Raf/MEK/ERK-mediated Growth Arrest Signaling

(2009) Seung-Keun Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY