Mechanisms of Action and Toxicity of the Mycotoxin Alternariol: A Review

Alternariol induce toxicity via cell death and mitochondrial damage on Caco-2 cells

(2016) Celia Fernández-Blanco et al.   FOOD AND CHEMICAL TOXICOLOGY

Occurrence of Alternaria toxins in food products in The Netherlands

(2016) Patricia López et al.   FOOD CONTROL

Development of a high performance liquid chromatography tandem mass spectrometry based analysis for the simultaneous quantification of various Alternaria toxins in wine, vegetable juices and fruit juices

(2016) Theresa Zwickel et al.   JOURNAL OF CHROMATOGRAPHY A

DNA damage and repair kinetics of the Alternaria mycotoxins alternariol, altertoxin II and stemphyltoxin III in cultured cells

(2016) Stefanie C. Fleck et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The mycotoxin alternariol induces DNA damage and modify macrophage phenotype and inflammatory responses

(2015) A. Solhaug et al.   TOXICOLOGY LETTERS

Oxidative DNA damage and disturbance of antioxidant capacity by alternariol in Caco-2 cells

(2015) Celia Fernández-Blanco et al.   TOXICOLOGY LETTERS

CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis

(2014) Ornella Cazzalini et al.   NUCLEIC ACIDS RESEARCH

Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol

(2014) A. Solhaug et al.   TOXICOLOGY

Oxidative stress of alternariol in Caco-2 cells

(2014) Celia Fernández-Blanco et al.   TOXICOLOGY LETTERS

Public Health Impacts of Foodborne Mycotoxins

(2014) Felicia Wu et al.   Annual Review of Food Science and Technology

Alternaria mycotoxins in wheat – A 10 years survey in the Northeast of Germany

(2013) Marina E.H. Müller et al.   FOOD CONTROL

An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol

(2013) Caroline Frizzell et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages

(2013) A. Solhaug et al.   TOXICOLOGY LETTERS

Role of topoisomerase inhibition and DNA repair mechanisms in the genotoxicity of alternariol and altertoxin-II

(2013) C. Tiessen et al.   World Mycotoxin Journal

From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol

(2013) Marc Maresca   Toxins

Faces of a Changing Climate: Semi-Quantitative Multi-Mycotoxin Analysis of Grain Grown in Exceptional Climatic Conditions in Norway

(2013) Silvio Uhlig et al.   Toxins

Mechanisms involved in alternariol-induced cell cycle arrest

(2012) A. Solhaug et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Cell death induced by the Alternaria mycotoxin Alternariol

(2012) Fatma Bensassi et al.   TOXICOLOGY IN VITRO

Alternaria toxins: Altertoxin II is a much stronger mutagen and DNA strand breaking mycotoxin than alternariol and its methyl ether in cultured mammalian cells

(2012) Stefanie C. Fleck et al.   TOXICOLOGY LETTERS

Modulation of the cellular redox status by the Alternaria toxins alternariol and alternariol monomethyl ether

(2012) Christine Tiessen et al.   TOXICOLOGY LETTERS

Current Situation of Mycotoxin Contamination and Co-occurrence in Animal Feed—Focus on Europe

(2012) Elisabeth Streit et al.   Toxins

The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor

(2011) Ilona Schreck et al.   ARCHIVES OF TOXICOLOGY

Mouse hepatoma cell lines differing in aryl hydrocarbon receptor-mediated signaling have different activities for glucuronidation

(2011) B. Burkhardt et al.   ARCHIVES OF TOXICOLOGY

Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells

(2011) Ning Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells

(2011) Karma C. Fussell et al.   CARCINOGENESIS

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Topoisomerase IIα maintains genomic stability through decatenation G2 checkpoint signaling

(2010) J J Bower et al.   ONCOGENE

Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1

(2010) Markus Fehr et al.   Mycotoxin Research

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

p53 Strikes mTORC1 by Employing Sestrins

(2008) Nissim Hay   Cell Metabolism

Alternariol acts as a topoisomerase poison, preferentially affecting the IIα isoform

(2008) Markus Fehr et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Influence of alternariol (AOH) on regulator proteins of cap-dependent translation in porcine endometrial cells

(2008) K WOLLENHAUPT et al.   TOXICOLOGY LETTERS

Alternaria mycotoxins: an overview of chemical characterization, producers, toxicity, analysis and occurrence in foodstuffs

(2008) V. Ostry   World Mycotoxin Journal