MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

(2016) Mireille Ouimet et al.   NATURE IMMUNOLOGY

Biallelic Mutations in the Autophagy Regulator DRAM2 Cause Retinal Dystrophy with Early Macular Involvement

(2015) Mohammed E. El-Asrag et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-κB Pathway

(2015) Manish Kumar et al.   Cell Host & Microbe

Macrophage defense mechanisms against intracellular bacteria

(2015) Günter Weiss et al.   IMMUNOLOGICAL REVIEWS

MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection

(2015) Jin Kyung Kim et al.   JOURNAL OF IMMUNOLOGY

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

(2015) Chul-Su Yang et al.   Nature Communications

microRNA-17-5p Modulates Bacille Calmette-Guerin Growth in RAW264.7 Cells by Targeting ULK1

(2015) Xiangguo Duan et al.   PLoS One

Binding Rubicon to cross the Rubicon

(2014) Kohichi Matsunaga et al.   Autophagy

Selective inhibition of IFNG-induced autophagy byMir155- andMir31-responsive WNT5A and SHH signaling

(2014) Sahana Holla et al.   Autophagy

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

(2014) Chul-Su Yang et al.   Autophagy

MIR125B1represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia

(2014) Cheng-Wu Zeng et al.   Autophagy

miRNAs can be generally associated with human pathologies as exemplified for miR-144*

(2014) Andreas Keller et al.   BMC Medicine

The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense

(2014) Michiel van der Vaart et al.   Cell Host & Microbe

Autophagy as an immune effector against tuberculosis

(2013) Steven B Bradfute et al.   CURRENT OPINION IN MICROBIOLOGY

Dormant Mycobacterium tuberculosis Fails To Block Phagosome Maturation and Shows Unexpected Capacity To Stimulate Specific Human T Lymphocytes

(2013) S. Mariotti et al.   JOURNAL OF IMMUNOLOGY

Kaposi's Sarcoma-Associated Herpesvirus K7 Modulates Rubicon-Mediated Inhibition of Autophagosome Maturation

(2013) Q. Liang et al.   JOURNAL OF VIROLOGY

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

Autophagosome formation—The role of ULK1 and Beclin1–PI3KC3 complexes in setting the stage

(2013) Martina Wirth et al.   SEMINARS IN CANCER BIOLOGY

MicroRNA-155 Promotes Autophagy to Eliminate Intracellular Mycobacteria by Targeting Rheb

(2013) Jinli Wang et al.   PLoS Pathogens

Vitamin D Induces Interleukin-1β Expression: Paracrine Macrophage Epithelial Signaling Controls M. tuberculosis Infection

(2013) Mark Verway et al.   PLoS Pathogens

Autophagy as an innate defense against mycobacteria

(2013) Eun-Kyeong Jo   Pathogens and Disease

Roles of Autophagy in Elimination of Intracellular Bacterial Pathogens

(2013) Eun-Kyeong Jo et al.   Frontiers in Immunology

miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1

(2012) Gozde Korkmaz et al.   Autophagy

MicroRNA regulation of autophagy

(2012) L. B. Frankel et al.   CARCINOGENESIS

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

Interactions of Pathogenic Bacteria with Autophagy Systems

(2012) Marija Cemma et al.   CURRENT BIOLOGY

Altered microRNA expression levels in mononuclear cells of patients with pulmonary and pleural tuberculosis and their relation with components of the immune response

(2012) Silvana V. Spinelli et al.   MOLECULAR IMMUNOLOGY

MicroRNA-21 targets the vitamin D–dependent antimicrobial pathway in leprosy

(2012) Philip T Liu et al.   NATURE MEDICINE

Common patterns and disease-related signatures in tuberculosis and sarcoidosis

(2012) J. Maertzdorf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy

(2011) Jim O’Prey et al.   CELL CYCLE

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Analysis of microRNA expression profiling identifies miR-155 and miR-155* as potential diagnostic markers for active tuberculosis: a preliminary study

(2011) Jing Wu et al.   HUMAN IMMUNOLOGY

Autophagy in immunity and cell-autonomous defense against intracellular microbes

(2011) Vojo Deretic   IMMUNOLOGICAL REVIEWS

Identification of Small Molecule Inhibitors of Phosphatidylinositol 3-Kinase and Autophagy

(2011) Thomas Farkas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating MicroRNAs in Patients with Active Pulmonary Tuberculosis

(2011) Y. Fu et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction

(2011) Jung-Ho Yoon et al.   MOLECULAR BIOLOGY REPORTS

Modulation of T cell cytokine production by miR-144* with elevated expression in patients with pulmonary tuberculosis

(2011) Yanhua Liu et al.   MOLECULAR IMMUNOLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Comparative miRNA Expression Profiles in Individuals with Latent and Active Tuberculosis

(2011) Chuan Wang et al.   PLoS One

Vitamin D Is Required for IFN- -Mediated Antimicrobial Activity of Human Macrophages

(2011) M. Fabri et al.   Science Translational Medicine

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression

(2010) Qiming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

(2010) Doron Betel et al.   GENOME BIOLOGY

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

NADPH Oxidase 2 Interaction with TLR2 Is Required for Efficient Innate Immune Responses to Mycobacteria via Cathelicidin Expression

(2009) C.-S. Yang et al.   JOURNAL OF IMMUNOLOGY

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

Autophagy, an immunologic magic bullet:Mycobacterium tuberculosisphagosome maturation block and how to bypass it

(2008) Vojo Deretic   Future Microbiology

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

Experimental validation of miRNA targets

(2007) Donald E. Kuhn et al.   METHODS