期刊
JOURNAL OF VIROLOGY
卷 87, 期 22, 页码 12499-12503出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01898-13
关键词
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类别
资金
- Hastings Foundation
- Fletcher Jones Foundation
- GRL Program of the National Research Foundation of Korea [K20815000001]
- [1F32AI096698]
- [CA180779]
- [CA082057]
- [CA31363]
- [CA115284]
- [AI073099]
- [AI083025]
- [HL110609]
Autophagy is an important innate safeguard mechanism for protecting an organism against invasion by pathogens. We have previously discovered that Kaposi's sarcoma-associated herpesvirus (KSHV) evades this host defense through tight suppression of autophagy by targeting multiple steps of autophagy signal transduction. Here, we report that KSHV K7 protein interacts with Rubicon autophagy protein and inhibits the autophagosome maturation step by blocking Vps34 enzymatic activity, further highlighting how KSHV deregulates autophagy-mediated host immunity for its life cycle.
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