Self-organizing neuruloids model developmental aspects of Huntington’s disease in the ectodermal compartment

Loss-of-huntingtin in medial and lateral ganglionic lineages differentially disrupts regional interneuron and projection neuron subtypes and promotes Huntington's disease-associated behavioral, cellular and pathological hallmarks

(2019) Mark F. Mehler et al.   JOURNAL OF NEUROSCIENCE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate

(2018) M. Zeeshan Ozair et al.   Cell Stem Cell

Chromosomal instability during neurogenesis in Huntington's disease

(2018) Albert Ruzo et al.   DEVELOPMENT

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells

(2018) Xufeng Xue et al.   NATURE MATERIALS

Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes

(2018) P. Conforti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition

(2018) Florian A. Siebzehnrübl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering induction of singular neural rosette emergence within hPSC-derived tissues

(2018) Gavin T Knight et al.   eLife

Fully Convolutional Networks for Semantic Segmentation

(2017) Evan Shelhamer et al.   IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE

Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology

(2017) Monia Barnat et al.   NEURON

WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate

(2016) Alan W. Leung et al.   DEVELOPMENT

A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization

(2016) Fred Etoc et al.   DEVELOPMENTAL CELL

Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease

(2016) Eduardo E. Arteaga-Bracho et al.   NEUROBIOLOGY OF DISEASE

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease

(2016) Aldrin E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generating trunk neural crest from human pluripotent stem cells

(2016) Miller Huang et al.   Scientific Reports

Patterns of Co-Occurring Gray Matter Concentration Loss across the Huntington Disease Prodrome

(2016) Jennifer Ashley Ciarochi et al.   Frontiers in Neurology

Network topology and functional connectivity disturbances precede the onset of Huntington’s disease

(2015) Deborah L. Harrington et al.   BRAIN

Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus

(2015) Chatterjee Mallika et al.   DEVELOPMENTAL BIOLOGY

Discovery of Novel Isoforms of Huntingtin Reveals a New Hominid-Specific Exon

(2015) Albert Ruzo et al.   PLoS One

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

(2015) Adam Labadorf et al.   PLoS One

Neural Tube Defects

(2014) Nicholas D.E. Greene et al.   Annual Review of Neuroscience

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease

(2014) Cendrine Tourette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

Molecular and functional definition of the developing human striatum

(2014) Marco Onorati et al.   NATURE NEUROSCIENCE

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Clinical and Biomarker Changes in Premanifest Huntington Disease Show Trial Feasibility: A Decade of the PREDICT-HD Study

(2014) Jane S. Paulsen et al.   Frontiers in Aging Neuroscience

Early embryonic specification of vertebrate cranial placodes

(2014) Gerhard Schlosser   Wiley Interdisciplinary Reviews-Developmental Biology

A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border

(2013) S. Reichert et al.   DEVELOPMENT

Signaling pathways regulating ectodermal cell fate choices

(2013) Cédric Patthey et al.   EXPERIMENTAL CELL RESEARCH

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Signals and Switches in Mammalian Neural Crest Cell Differentiation

(2013) S. Bhatt et al.   Cold Spring Harbor Perspectives in Biology

Specification of Functional Cranial Placode Derivatives from Human Pluripotent Stem Cells

(2013) Zehra Dincer et al.   Cell Reports

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

(2012) Valentina Lo Sardo et al.   NATURE NEUROSCIENCE

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

SMAD7 Directly Converts Human Embryonic Stem Cells to Telencephalic Fate by a Default Mechanism

(2012) Mohammad Zeeshan Ozair et al.   STEM CELLS

Neural induction and early patterning in vertebrates

(2012) Mohammad Zeeshan Ozair et al.   Wiley Interdisciplinary Reviews-Developmental Biology

FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction

(2011) T. J. Stuhlmiller et al.   DEVELOPMENT

The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

Genomic code for Sox10 activation reveals a key regulatory enhancer for cranial neural crest

(2010) Paola Betancur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Early Requirements for Preplacodal Ectoderm and Sensory Organ Development

(2010) Hye-Joo Kwon et al.   PLoS Genetics

Brn3a and Nurr1 Mediate a Gene Regulatory Pathway for Habenula Development

(2009) L. A. Quina et al.   JOURNAL OF NEUROSCIENCE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Huntingtin as an essential integrator of intracellular vesicular trafficking

(2009) Juliane P. Caviston et al.   TRENDS IN CELL BIOLOGY

Wnt6 expression in epidermis and epithelial tissues duringXenopusorganogenesis

(2008) Danielle L. Lavery et al.   DEVELOPMENTAL DYNAMICS

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

(2008) Y. Elkabetz et al.   GENES & DEVELOPMENT

The human keratins: biology and pathology

(2008) Roland Moll et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A gene regulatory network orchestrates neural crest formation

(2008) Tatjana Sauka-Spengler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Leopard syndrome

(2008) Anna Sarkozy et al.   Orphanet Journal of Rare Diseases

Detection of Huntington's disease decades before diagnosis: the Predict-HD study

(2007) J S Paulsen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY