Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition

Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes

(2018) P. Conforti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington Disease as a Neurodevelopmental Disorder and Early Signs of the Disease in Stem Cells

(2017) Kalina Wiatr et al.   MOLECULAR NEUROBIOLOGY

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

(2017) Ryan G Lim et al.   NATURE NEUROSCIENCE

Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease

(2016) Eduardo E. Arteaga-Bracho et al.   NEUROBIOLOGY OF DISEASE

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease

(2016) Aldrin E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington’s disease: involvement of astrocyte–neuron interactions

(2016) F L'Episcopo et al.   Cell Death & Disease

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease

(2015) Jing Jin et al.   HUMAN MOLECULAR GENETICS

Reduction in Subventricular Zone-Derived Olfactory Bulb Neurogenesis in a Rat Model of Huntington’s Disease Is Accompanied by Striatal Invasion of Neuroblasts

(2015) Mahesh Kandasamy et al.   PLoS One

Mutant Huntingtin Affects Cortical Progenitor Cell Division and Development of the Mouse Neocortex

(2014) M. Molina-Calavita et al.   JOURNAL OF NEUROSCIENCE

Rat choroidal pericytes as a target of the autonomic nervous system

(2013) Falk Schrödl et al.   CELL AND TISSUE RESEARCH

Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease

(2013) Sofia Hult Lundh et al.   HUMAN MOLECULAR GENETICS

Selective Roles of Normal and Mutant Huntingtin in Neural Induction and Early Neurogenesis

(2013) Giang D. Nguyen et al.   PLoS One

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Evaluation of olfactory dysfunction in neurodegenerative diseases

(2012) Marina Barresi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease

(2012) Nicole M. Lewandowski et al.   NEUROBIOLOGY OF DISEASE

Measures of growth in children at risk for Huntington disease

(2012) J. K. Lee et al.   NEUROLOGY

Neurotransmitters couple brain activity to subventricular zone neurogenesis

(2011) Stephanie Z. Young et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neurodegenerative disease and adult neurogenesis

(2011) Beate Winner et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Early Alterations of Brain Cellular Energy Homeostasis in Huntington Disease Models

(2011) Fanny Mochel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microstructural changes observed with DKI in a transgenic Huntington rat model: Evidence for abnormal neurodevelopment

(2011) Ines Blockx et al.   NEUROIMAGE

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

(2011) L.A. Raymond et al.   NEUROSCIENCE

SAHA Decreases HDAC 2 and 4 Levels In Vivo and Improves Molecular Phenotypes in the R6/2 Mouse Model of Huntington's Disease

(2011) Michal Mielcarek et al.   PLoS One

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

(2011) N. H. Pipalia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease

(2010) Zacharias Kohl et al.   BMC NEUROSCIENCE

Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment

(2010) Peggy C. Nopoulos et al.   BRAIN

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dopamine and Glutamate in Huntington's Disease: A Balancing Act

(2010) Véronique M. André et al.   CNS Neuroscience & Therapeutics

Is Huntington disease a developmental disorder?

(2010) Sandrine Humbert   EMBO REPORTS

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease

(2010) Jill R. Crittenden et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of Huntingtin at Ser421 in YAC128 Neurons Is Associated with Protection of YAC128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A

(2010) M. Metzler et al.   JOURNAL OF NEUROSCIENCE

Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease

(2010) Jessica M. Simpson et al.   NEUROBIOLOGY OF DISEASE

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

(2010) Austen J. Milnerwood et al.   NEURON

Neurogenesis in the R6/2 mouse model of Huntington's disease is impaired at the level of NeuroD1

(2010) V. Fedele et al.   NEUROSCIENCE

A niche for adult neurogenesis in social behavior

(2009) Gilles Gheusi et al.   BEHAVIOURAL BRAIN RESEARCH

Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease

(2009) A. E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex differences in a transgenic rat model of Huntington's disease: decreased 17β-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males

(2008) Felix J. Bode et al.   HUMAN MOLECULAR GENETICS

Polyglutamine-Modulated Striatal Calpain Activity in YAC Transgenic Huntington Disease Mouse Model: Impact on NMDA Receptor Function and Toxicity

(2008) C. M. Cowan et al.   JOURNAL OF NEUROSCIENCE

Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

(2008) M. Gray et al.   JOURNAL OF NEUROSCIENCE

A Large Number of Protein Expression Changes Occur Early in Life and Precede Phenotype Onset in a Mouse Model for Huntington Disease

(2008) Claus Zabel et al.   MOLECULAR & CELLULAR PROTEOMICS

Age-dependent gene expression profile and protein expression in a transgenic rat model of Huntington's disease

(2008) Huu Phuc Nguyen et al.   Proteomics Clinical Applications

Detection of Huntington's disease decades before diagnosis: the Predict-HD study

(2007) J S Paulsen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Evaluation of exploration and risk assessment in pre-weaning mice using the novel cage test

(2007) Joana M. Marques et al.   PHYSIOLOGY & BEHAVIOR