RNA editing in the forefront of epitranscriptomics and human health

A-to-I RNA Editing: An Overlooked Source of Cancer Mutations

(2018) Shay Ben-Aroya et al.   CANCER CELL

RNA editing in nascent RNA affects pre-mRNA splicing

(2018) Yun-Hua Esther Hsiao et al.   GENOME RESEARCH

Transcriptogenomics identification and characterization of RNA editing sites in human primary monocytes using high-depth next generation sequencing data

(2018) Wai-Mun Leong et al.   GENOMICS

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity

(2018) Arunkumar Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligands

(2018) Jason D. Salter et al.   TRENDS IN BIOCHEMICAL SCIENCES

Massive mining of publicly available RNA-seq data from human and mouse

(2018) Alexander Lachmann et al.   Nature Communications

Accurate identification of RNA editing sites from primitive sequence with deep neural networks

(2018) Zhangyi Ouyang et al.   Scientific Reports

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

(2018) Phillip M. Shelton et al.   Cell Reports

RNA Editing and Retrotransposons in Neurology

(2018) Heinz Krestel et al.   Frontiers in Molecular Neuroscience

Epitranscriptomics: A New Regulatory Mechanism of Brain Development and Function

(2018) Florian Noack et al.   Frontiers in Neuroscience

Adar3 Is Involved in Learning and Memory in Mice

(2018) Dessislava Mladenova et al.   Frontiers in Neuroscience

Dynamic temperature-sensitive A-to-I RNA editing in the brain of a heterothermic mammal during hibernation

(2018) Kent A Riemondy et al.   RNA

RNA editing derived epitopes function as cancer antigens to elicit immune responses

(2018) Minying Zhang et al.   Nature Communications

ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep

(2018) Ketty Sinigaglia et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries

(2018) Kajsa Fritzell et al.   NUCLEIC ACIDS RESEARCH

RNA editing in bacteria recodes multiple proteins and regulates an evolutionarily conserved toxin-antitoxin system

(2017) Dan Bar-Yaacov et al.   GENOME RESEARCH

Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

(2017) Yumeng Wang et al.   GENOME RESEARCH

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

RNA editing ofSLC22A3drives early tumor invasion and metastasis in familial esophageal cancer

(2017) Li Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restricting retrotransposons: ADAR1 is another guardian of the human genome

(2017) Elisa Orecchini et al.   RNA Biology

High expression of PD-1 ligands is associated with kataegis mutational signature and APOBEC3 alterations

(2017) Amélie Boichard et al.   OncoImmunology

Complex regulation of ADAR-mediated RNA-editing across tissues

(2016) Melanie A. Huntley et al.   BMC GENOMICS

ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma

(2016) Yuan-Bin Chen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Identification of human RNA editing sites: A historical perspective

(2016) Gokul Ramaswami et al.   METHODS

ADARB1 catalyzes circadian A-to-I editing and regulates RNA rhythm

(2016) Hideki Terajima et al.   NATURE GENETICS

Dynamic regulation of RNA editing in human brain development and disease

(2016) Taeyoung Hwang et al.   NATURE NEUROSCIENCE

REDIportal: a comprehensive database of A-to-I RNA editing events in humans

(2016) Ernesto Picardi et al.   NUCLEIC ACIDS RESEARCH

LNCediting: a database for functional effects of RNA editing in lncRNAs

(2016) Jing Gong et al.   NUCLEIC ACIDS RESEARCH

The APOBEC Protein Family: United by Structure, Divergent in Function

(2016) Jason D. Salter et al.   TRENDS IN BIOCHEMICAL SCIENCES

DNA Editing by APOBECs: A Genomic Preserver and Transformer

(2016) Binyamin A. Knisbacher et al.   TRENDS IN GENETICS

ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity

(2016) J. E. Robinson et al.   Nature Communications

The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis

(2016) Kiranmai Gumireddy et al.   Nature Communications

Altered RNA editing in 3′ UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors

(2016) Liye Zhang et al.   Scientific Reports

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

(2016) E. K. Law et al.   Science Advances

RNA editing of non-coding RNA and its role in gene regulation

(2015) Chammiran Daniel et al.   BIOCHIMIE

The origin of the ADAR gene family and animal RNA editing

(2015) Laura F Grice et al.   BMC EVOLUTIONARY BIOLOGY

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

(2015) Leng Han et al.   CANCER CELL

Site-Directed RNA Editing in Vivo Can Be Triggered by the Light-Driven Assembly of an Artificial Riboprotein

(2015) Alfred Hanswillemenke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

(2015) Einav Shoshan et al.   NATURE CELL BIOLOGY

Genome sequence–independent identification of RNA editing sites

(2015) Qing Zhang et al.   NATURE METHODS

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in spinal motor neurons of conditional ADAR2-knockout mice: An implication for a role of calcium in increased autophagy flux in ALS

(2015) Soichi Sasaki et al.   NEUROSCIENCE LETTERS

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis

(2015) C Anadón et al.   ONCOGENE

Genome-wide identification and characterization of tissue-specific RNA editing events inD. melanogasterand their potential role in regulating alternative splicing

(2015) Alborz Mazloomian et al.   RNA Biology

Profiling RNA editing in human tissues: towards the inosinome Atlas

(2015) Ernesto Picardi et al.   Scientific Reports

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors

(2015) Nurit Paz-Yaacov et al.   Cell Reports

The Epitranscriptome and Innate Immunity

(2015) Mary A. O’Connell et al.   PLoS Genetics

Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma

(2015) Sara Tomaselli et al.   GENOME BIOLOGY

APOBEC3A Is Implicated in a Novel Class of G-to-A mRNA Editing in WT1 Transcripts

(2015) Ahmadreza Niavarani et al.   PLoS One

C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47

(2014) N. Fossat et al.   EMBO REPORTS

A-to-I editing on tRNAs: Biochemical, biological and evolutionary implications

(2014) Adrian Gabriel Torres et al.   FEBS LETTERS

RNA editing inRHOQpromotes invasion potential in colorectal cancer

(2014) Sae-Won Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Elevated APOBEC3B Correlates with Poor Outcomes for Estrogen-Receptor-Positive Breast Cancers

(2014) Anieta M. Sieuwerts et al.   Hormones & Cancer

Potent and Selective Inhibition of A-to-I RNA Editing with 2′-O-Methyl/Locked Nucleic Acid-Containing Antisense Oligoribonucleotides

(2013) Rena A. Mizrahi et al.   ACS Chemical Biology

Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma

(2013) Y.-R. Qin et al.   CANCER RESEARCH

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

(2013) Leilei Chen et al.   NATURE MEDICINE

The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster

(2013) X. Li et al.   NUCLEIC ACIDS RESEARCH

Proteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules

(2013) Siew Kit Ng et al.   NUCLEIC ACIDS RESEARCH

RADAR: a rigorously annotated database of A-to-I RNA editing

(2013) Gokul Ramaswami et al.   NUCLEIC ACIDS RESEARCH

Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma

(2013) P N Valdmanis et al.   ONCOGENE

Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing

(2013) M. F. Montiel-Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression

(2013) Isabel X. Wang et al.   Cell Reports

Adenosine-to-inosine RNA editing and human disease

(2013) William Slotkin et al.   Genome Medicine

The Role of Cytidine Deaminases on Innate Immune Responses against Human Viral Infections

(2013) Valdimara C. Vieira et al.   Biomed Research International

Evolutionary Origin of RNA Editing

(2012) Michael W. Gray   BIOCHEMISTRY

Constructive neutral evolution: exploring evolutionary theory’s curious disconnect

(2012) Arlin Stoltzfus   Biology Direct

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

RNA editing in the human ENCODE RNA-seq data

(2012) E. Park et al.   GENOME RESEARCH

A-to-I editing of microRNAs in the mammalian brain increases during development

(2012) Y. Ekdahl et al.   GENOME RESEARCH

Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells

(2012) Yukti Choudhury et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome

(2012) Zhiyu Peng et al.   NATURE BIOTECHNOLOGY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis

(2012) F Galeano et al.   ONCOGENE

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

The ADAR protein family

(2012) Yiannis A Savva et al.   GENOME BIOLOGY

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

Pin1 and WWP2 regulateGluR2Q/R site RNA editing by ADAR2 with opposing effects

(2011) Roberto Marcucci et al.   EMBO JOURNAL

Accurate identification of A-to-I RNA editing in human by transcriptome sequencing

(2011) J. H. Bahn et al.   GENOME RESEARCH

Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis

(2011) Shunsuke Okuyama et al.   INTERNATIONAL JOURNAL OF CANCER

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

(2011) Qingqing Ding et al.   JOURNAL OF CLINICAL INVESTIGATION

The innate antiviral factor APOBEC3G targets replication of measles, mumps and respiratory syncytial viruses

(2011) M. Fehrholz et al.   JOURNAL OF GENERAL VIROLOGY

Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1

(2011) J. F. Hultquist et al.   JOURNAL OF VIROLOGY

Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems

(2011) Lakshminarayan M. Iyer et al.   NUCLEIC ACIDS RESEARCH

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects

(2011) Liam P. Keegan et al.   NUCLEIC ACIDS RESEARCH

Functions and regulation of the APOBEC family of proteins

(2011) Harold C. Smith et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

(2011) Charles E. Samuel   VIROLOGY

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

Up-regulation of Activation-Induced Cytidine Deaminase Causes Genetic Aberrations at the CDKN2b-CDKN2a in Gastric Cancer

(2010) Yuko Matsumoto et al.   GASTROENTEROLOGY

AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model

(2010) Y Komeno et al.   LEUKEMIA

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

The RNA modification database, RNAMDB: 2011 update

(2010) W. A. Cantara et al.   NUCLEIC ACIDS RESEARCH

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

(2010) Eric W. Refsland et al.   NUCLEIC ACIDS RESEARCH

Large-scale detection and analysis of RNA editing in grape mtDNA by RNA deep-sequencing

(2010) Ernesto Picardi et al.   NUCLEIC ACIDS RESEARCH

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale mRNA sequencing determines global regulation of RNA editing during brain development

(2009) H. Wahlstedt et al.   GENOME RESEARCH

Origins and evolution of ADAR-mediated RNA editing

(2009) Yongfeng Jin et al.   IUBMB LIFE

Deficiency in APOBEC2 Leads to a Shift in Muscle Fiber Type, Diminished Body Mass, and Myopathy

(2009) Yusuke Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restriction of Equine Infectious Anemia Virus by Equine APOBEC3 Cytidine Deaminases

(2009) J. Zielonka et al.   JOURNAL OF VIROLOGY

RNA-Regulated Interaction of Transportin-1 and Exportin-5 with the Double-Stranded RNA-Binding Domain Regulates Nucleocytoplasmic Shuttling of ADAR1

(2009) J. Fritz et al.   MOLECULAR AND CELLULAR BIOLOGY

A Cytidine Deaminase Edits C to U in Transfer RNAs in Archaea

(2009) L. Randau et al.   SCIENCE

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous Retroelements

(2008) Ya-Lin Chiu et al.   Annual Review of Immunology

Alu element-mediated gene silencing

(2008) Ling-Ling Chen et al.   EMBO JOURNAL

Altered editing in cyclic nucleotide phosphodiesterase 8A1 gene transcripts of systemic lupus erythematosus T lymphocytes

(2008) Robert J. Orlowski et al.   IMMUNOLOGY

AID expression levels determine the extent ofcMyconcogenic translocations and the incidence of B cell tumor development

(2008) Makiko Takizawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs

(2008) Rodolphe Suspène et al.   NUCLEIC ACIDS RESEARCH