Article
Medicine, Research & Experimental
Sen Hong, Shiquan Li, Miaomiao Bi, Haiyao Yu, Zhenkun Yan, Tao Liu, Helei Wang
Summary: In colorectal cancer, the lncRNA ILF3-AS1 and EZH2 levels are increased, while CDKN2A is reduced. The expression of ILF3-AS1 and EZH2 is associated with Dukes stage, distant metastasis, vascular invasion, and lymph node metastasis in CRC patients. Depletion of ILF3-AS1 or reduction of EZH2 inhibits proliferation, migration, colony formation, and invasion of CRC cells, promotes apoptosis, and attenuates tumor growth in CRC mice.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Medicine, Research & Experimental
Jianming Lu, Chuanfan Zhong, Junqi Luo, Fangpeng Shu, Daojun Lv, Zezhen Liu, Xiao Tan, Shuo Wang, Kaihui Wu, Taowei Yang, Weibo Zhong, Bin Wang, Yanfei Chen, Yuehan Li, Zhenyu Jia, Yaguang Zou, Weide Zhong, Xiangming Mao
Summary: This study demonstrated the biological relevance of circCSPP1 and HnRNP-L in the progression of prostate cancer, indicating that increased circCSPP1 in prostate cancer cells regulated by HnRNP-L can induce autophagy, leading to enhanced proliferation, migration, and invasion. Furthermore, a potential competing endogenous RNA network involving circCSPP1, miR-520h, and EGR1 was revealed in prostate cancer cells, suggesting its significance in prostate cancer progression.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Jiawei Sun, Zizhen Zhang, Jingyu Chen, Meng Xue, Xia Pan
Summary: High expression of ELTD1 is correlated with lymph node metastasis and poor outcomes in colorectal cancer, promoting invasion and metastasis of CRC both in vitro and in vivo. Additionally, ELTD1 accelerates MMP2 transcriptional activity, potentially serving as a novel target for CRC metastasis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Chengcheng He, Aimin Li, Qiuhua Lai, Jian Ding, Qun Yan, Side Liu, Qingyuan Li
Summary: The study demonstrates that DDX39B is overexpressed in CRC tissues, facilitating CRC metastasis by upregulating FUT3 expression, promoting the activation of the TGF beta signaling pathway, and ultimately driving the progression of CRC through epithelial-mesenchymal transition.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Ying-Yu Liao, Ya-Ting Chuang, Hsuan-Yu Lin, Neng-Yu Lin, Tzu-Wen Hsu, Szu-Chia Hsieh, Syue-Ting Chen, Ji-Shiang Hung, Hung-Jen Yang, Jin-Tung Liang, Min-Chuan Huang, John Huang
Summary: GALNT2 overexpression in colorectal tumors is associated with poor survival of patients and promotes invasion by regulating the proteasome-dependent degradation pathway of AXL protein.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Junfeng Qiu, Mingzhou Li, Cailin Su, Yihao Liang, Ruizhang Ou, Xiaoning Chen, Chengmei Huang, Yaxin Zhang, Yaping Ye, Wenting Liao, Chao Zhang
Summary: This study found that in colorectal cancer (CRC), the expression of FOXS1 is upregulated and is positively correlated with poor survival. FOXS1 promotes malignant behavior of CRC cells, including proliferation, invasion, and angiogenesis, both in vitro and in vivo. Mechanistically, FOXS1 upregulates the transcriptional level of CXCL8 to regulate tumor growth and metastasis. These findings suggest that the FOXS1/CXCL8 axis may serve as a potential therapeutic target for the treatment of metastatic CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shuyun Wang, Limin Nie, Yuxiao Song, Fang Zhang, Xiaozheng Chen, Wenjing Shi, Zijiang Yang, Yuping Sun, Qi Dang, Aiqin Gao
Summary: The study found that NRTN is enriched in colorectal cancer cells and predicts poor patient outcomes. Upregulated NRTN enhances cancer cell motility and angiogenesis, promoting tumor invasion and metastasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Qian Liang, Yun Wang, Yingsi Lu, Qingqing Zhu, Wenlin Xie, Nannan Tang, Lifen Huang, Tailai An, Di Zhang, Anqi Yan, Shaoyu Liu, Liping Ye, Chengming Zhu
Summary: The study revealed the functional expression of RANK in human CRC cells and demonstrated that RANK induced the Ca2+-calcineurin/NFATC1-ACP5 axis in the regulation of CRC metastasis, that might be amenable to therapeutic targeting.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Guodong Liu, Xiwu Ouyang, Liansheng Gong, Lei Yao, Shiqing Liu, Jiarong Li, Qi Zhang, Yao Xiao
Summary: The study reveals the crucial role of circ-PRKAR1B in liver cancer progression, promoting cancer advancement through the miR-432-5p/E2F3 pathway. Clinical data and animal experiments further confirm the significance of this newly identified signaling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Sang-Soo Park, Yea Seong Ryu, Dong-In Koh, Seung-Woo Hong, Jai-Hee Moon, Jae-Sik Shin, Mi Jin Kim, Do Yeon Kim, Jun Ki Hong, Eun Ho Kim, Hong-Rae Jeong, Yoon Sun Park, Joseph Kim, Dong Min Kim, Hyeseon Yun, Joo-Yeon Shin, Dong-Hoon Jin
Summary: SVCT2 E264K mutation plays a critical role in proliferation in colorectal cancer (CRC), with its overexpression increasing cell growth and knockdown reducing cell proliferation while promoting apoptosis. The findings suggest that SVCT2 E264K could be a promising novel therapeutic target in CRC.
Article
Biochemistry & Molecular Biology
Kaisa Cui, Liang Gong, Han Zhang, Ying Chen, Bingxin Liu, Zhicheng Gong, Jiuming Li, Yuanben Wang, Shengbai Sun, Yajun Li, Qiang Zhang, Yulin Cao, Qilin Li, Bojian Fei, Zhaohui Huang
Summary: This study reveals that the RNA exosome gene (EXOSC8) promotes colorectal cancer (CRC) tumorigenesis by regulating cancer-related ribosome biogenesis in CRC. Silencing of EXOSC8 decreases levels of nucleolar proteins and proliferation markers, as well as rRNA/DNA and global protein syntheses. EXOSC8 knockdown triggers ribosomal stress, releasing nucleolar protein RPL5/11 into the nucleoplasm and hijacking Mdm2 to block its E3 ubiquitin ligase function, thereby releasing and activating p53. EXOSC8 may serve as a potential therapeutic target in CRC.
Review
Oncology
Shanshan Chen, Yi Fang, Lingyu Sun, Ruonan He, Beihui He, Shuo Zhang
Summary: This review discusses the potential mechanisms of several oncogenic and suppressor lncRNAs in the occurrence and development of CRC, aiming to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Tianqi Wu, Jian Wan, Xiao Qu, Kai Xia, Fangtao Wang, Zichao Zhang, Muqing Yang, Xiaocai Wu, Renyuan Gao, Xiaoqi Yuan, Lin Fang, Chunqiu Chen, Lu Yin
Summary: Nodal plays an important role in colorectal cancer by promoting cell growth, invasiveness, and epithelial-mesenchymal transition, as well as increasing lipid unsaturation levels. It activates the Smad2/3 pathway to up-regulate the transcription of Stearoyl-coenzyme A desaturase 1 (SCD1) and confer resistance to ferroptosis. Up-regulation of Nodal and SCD1 is associated with metastasis and poor clinical outcomes in colorectal cancer.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee
Summary: ICAM-1 is a potential therapeutic target for colorectal cancer (CRC) that enhances treatment effectiveness by promoting the c-MET-SRC signaling axis. Treatment with antibodies targeting ICAM-1 can reduce metastasis and angiogenesis in CRC.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Tianze Huang, Yanyun Lin, Junguo Chen, Jiancong Hu, Hao Chen, Yanhong Zhang, Bin Zhang, Xiaosheng He
Summary: The abundant nervous system in the intestine provides the foundation for perineural invasion (PNI) of colorectal cancer (CRC). In this study, it is demonstrated for the first time that CD51 can be cleaved by gamma-secretase to generate an intracellular domain (ICD) that promotes PNI. Pharmacological inhibition of gamma-secretase can prevent PNI in CRC and may be a potential therapeutic target.
Article
Oncology
Seong-Woo Bae, Felix Berlth, Kyoung-Yun Jeong, Ji-Hyeon Park, Jong-Ho Choi, Shin-Hoo Park, Yun-Suhk Suh, Seong-Ho Kong, Do-Joong Park, Hyuk-Joon Lee, Charles Lee, Jong-Il Kim, Hyewon Youn, Hongyoon Choi, Gi Jeong Cheon, Keon Wook Kang, Han-Kwang Yang
Summary: This study developed a genetic signature, PETscore, to predict the metabolic activity of GC and identified five genes associated with [F-18]FDG uptake in GC. The PETscore was validated using human GC data and revealed associations between glucose uptake, tumor mutational burden, and genomic alterations in GC.
Article
Oncology
Bum-Sup Jang, Ji-Hyun Chang, Seung Hyuck Jeon, Myung Geun Song, Kyung-Hun Lee, Seock-Ah Im, Jong-Il Kim, Tae-You Kim, Eui Kyu Chie
Summary: The value of genomic profiling for predicting radiation therapy response was evaluated and a Bayesian network model was constructed. Alterations of DNA repair pathway and smoking somatic signature were associated with durable radiation response. The Bayesian network model provided helpful insights for high precision radiotherapy. However, further validation in prospective cohorts is needed for individualized treatment.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Yukyung Jun, Yun-Suhk Suh, SungHee Park, Jieun Lee, Jong-Il Kim, Sanghyuk Lee, Wan-Ping Lee, Olga Anczukow, Han-Kwang Yang, Charles Lee
Summary: This study provides a comprehensive analysis of the significance of alternative splicing in patient classification, molecular mechanisms, and prognosis in gastric cancer.
Article
Computer Science, Interdisciplinary Applications
Woo June Choi, Jung-Ki Yoon, Bjorn Paulson, Chang-Hoon Lee, Jae-Joon Yim, Jong-Il Kim, Jun Ki Kim
Summary: The new video microscopy technique combines motion-contrast imaging and image correlation to provide objective and selective ciliary beat frequency (CBF) measurements. The method's performance was validated with in vitro human airway organoid models, showing robustness to optical focal shifts and exhibiting spatial heterogeneity and temperature dependence.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Gastroenterology & Hepatology
Hye-Yeong Jin, Seung-Yeon Yoo, Ji-Ae Lee, Xianyu Wen, Younghoon Kim, Hye Eun Park, Yoonjin Kwak, Nam-Yun Cho, Jeong Mo Bae, Jung Ho Kim, Hye Seung Lee, Gyeong Hoon Kang
Summary: Tumor stroma and tumor-infiltrating lymphocytes (TILs) have different effects on the prognosis of colorectal cancer (CRC) patients. The combinatory statuses of tumor-stromal percentage (TSP) and TILs can provide powerful prognostic information for CRCs.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Ju Hee Kim, Eun-Shin Lee, Jihui Yun, Han Suk Ryu, Hong Kyu Kim, Young Wook Ju, Kwangsoo Kim, Jong-Il Kim, Hyeong-Gon Moon
Summary: CASQ2, a newly identified breast cancer-related gene, has been found to potentially regulate tumor-microenvironment interactions by promoting a more aggressive phenotype and altering epithelial-mesenchymal transition (EMT) markers in breast cancer cells. Overexpression of CASQ2 also induces cancer-associated fibroblast characteristics and increases hypoxia-inducible factor 1 alpha (HIF1 alpha) expression in stromal fibroblasts, leading to accelerated tumorigenesis, collagen structure remodeling, and distant metastasis in vivo. CASQ2 may confer more metaplastic features to triple-negative breast cancer cells, suggesting its key role in breast cancer tumorigenesis and metastasis through modulating various aspects of tumor-microenvironment interactions.
MOLECULAR ONCOLOGY
(2022)
Article
Pathology
Ji Ae Lee, Mi-Kyoung Seo, Seung-Yeon Yoo, Nam-Yun Cho, Yoonjin Kwak, Kyoungbun Lee, Jung Ho Kim, Gyeong Hoon Kang
Summary: Decreased expression of CDX2, SATB2, and KRT20 in colorectal carcinomas (CRCs) is commonly associated with microsatellite instability-high (MSI-H) and CpG island methylator phenotype-high (CIMP-H), but the specific features associated with the loss of each marker differ in CRCs.
Article
Multidisciplinary Sciences
Xianyu Wen, Hye-Yeong Jin, Meihui Li, Younghoon Kim, Nam-Yun Cho, Yoonjin Kwak, Jeong Mo Bae, Hye Seung Lee, Gyeong Hoon Kang
Summary: Through genome-wide methylation profiling, the methylation markers NCOR2, PARK2, and ZSCAN12 were found to be closely associated with the density of CD3-positive and CD8-positive cells and could serve as biomarkers for predicting the prognosis of patients with gastric carcinoma.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Jaeyong Choi, Woochan Lee, Jung-Ki Yoon, Sun Mi Choi, Chang-Hoon Lee, Hyeong-Gon Moon, Sukki Cho, Jin-Haeng Chung, Han-Kwang Yang, Jong-Il Kim
Summary: The study evaluated misalignment errors and exonic multi-mapping events in mixed human and mouse single-cell data analysis, and developed a new bioinformatics pipeline to minimize errors. Results showed that the clustering effect of data processed using this pipeline was good compared to unmixed data, effectively identified false-positive signals caused by ambient RNA, and successfully applied to the analysis of multispecies multisample single-cell libraries.
BMC BIOINFORMATICS
(2022)
Article
Gastroenterology & Hepatology
Sang Sik Cho, Ji Won Park, Gyeong Hoon Kang, Jung Ho Kim, Jeong Mo Bae, Sae-Won Han, Tae-You Kim, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
Summary: This study aimed to determine whether the location of lymphatic invasion, vascular invasion, and perineural invasion could affect the survival of patients with stage II colon cancer. The results showed that extramural invasion was associated with a worse prognosis, while intramural invasion was not. Therefore, pathologic reports about the location of invasion may be helpful for predicting prognosis and determining the need for adjuvant chemotherapy in stage II colon cancers.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Genetics & Heredity
Jeong Mo Bae, Ji Young Ahn, Heonyi Lee, Hoon Jang, Hyojun Han, Jaehwan Jeong, Nam-Yun Cho, Kwangsoo Kim, Gyeong Hoon Kang
Summary: DNA methylation profiling is a promising method for predicting the tissue of origin in cancer patients. By extracting genomic DNA from formalin-fixed tissues, a targeted bisulfite sequencing panel based on hybrid capture has been developed and found to be useful in clinical practice.
Article
Clinical Neurology
H. Chung, H. Seo, S. H. Choi, C. -k. Park, T. M. Kim, S. -h. Park, J. K. Won, J. H. Lee, S. -t. Lee, J. Y. Lee, I. Hwang, K. M. Kang, T. J. Yun
Summary: This study developed a machine learning-based model to identify preoperative multiparametric MR imaging markers associated with prognosis in glioblastoma patients. The model found that nonenhancing T2 high-signal-intensity lesions with the relatively low normalized CBV, low volume transfer constant values, and the lowest ADC values could serve as useful prognostic imaging markers for predicting survival outcomes in patients with glioblastoma.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Pathology
Jiwon Koh, Ha Young Park, Jeong Mo Bae, Jun Kang, Uiju Cho, Seung Eun Lee, Haeyoun Kang, Min Eui Hong, Jae Kyung Won, Youn-La Choi, Wan-Seop Kim, Ahwon Lee
Summary: The importance of molecular pathology tests has increased in the past decade, leading to a demand for efficient training in this field. The Korean Society of Pathologists established a task force to develop a refined educational curriculum in molecular pathology. An online educational session was conducted, and the understanding of the participants significantly increased in various learning objectives, particularly in the field of next-generation sequencing. The feedback received on the refined curriculum was predominantly positive.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Younghoon Kim, Gyeong Hoon Kang, Haeryoung Kim
Summary: A systematic review and meta-analysis showed that the presence of heterologous component is associated with worse overall survival in gynecologic carcinosarcoma, but not with recurrence-free survival and disease-free survival.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Jaeyong Choi, Seung Mi Lee, Errol R. Norwitz, Ji Hoi Kim, Young Mi Jung, Chan-Wook Park, Jong Kwan Jun, Jong-Il Kim, Joong Shin Park
REPRODUCTIVE SCIENCES
(2022)