标题
Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 19, Pages 4719
出版商
MDPI AG
发表日期
2019-09-23
DOI
10.3390/ijms20194719
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- STAT3 inhibition specifically in human monocytes and macrophages by CD163-targeted corosolic acid-containing liposomes
- (2019) Morten Nørgaard Andersen et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Iron as a Central Player and Promising Target in Cancer Progression
- (2019) Michaela Jung et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phase I dose-escalation study of chiauranib, a novel angiogenic, mitotic, and chronic inflammation inhibitor, in patients with advanced solid tumors
- (2019) Yongkun Sun et al. Journal of Hematology & Oncology
- Imaging endogenous macrophage iron deposits reveals a metabolic biomarker of polarized tumor macrophage infiltration and response to CSF1R breast cancer immunotherapy
- (2019) Avigdor Leftin et al. Scientific Reports
- A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression
- (2019) Francesca R. Auciello et al. Cancer Discovery
- The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
- (2019) Biao Ma et al. Nature Communications
- Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma
- (2019) Laurene S. Cheung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8+ T cells through reduction of tumor-associated macrophage and activation of the interferon pathway
- (2019) Yu Kato et al. PLoS One
- CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes
- (2019) Moritz Rapp et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Targeting Tumor Microenvironment for Cancer Therapy
- (2019) Catarina Roma-Rodrigues et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Depletion of tumor-associated macrophages enhances the anti-tumor effect of docetaxel in a murine epithelial ovarian cancer
- (2019) Xiaofen Lu et al. IMMUNOBIOLOGY
- Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages
- (2019) Akihiro Maeda et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression
- (2019) Pieter Goossens et al. Cell Metabolism
- Phase I Study of Emactuzumab Single Agent or in Combination with Paclitaxel in Patients with Advanced/Metastatic Solid Tumors Reveals Depletion of Immunosuppressive M2-like Macrophages
- (2019) C A Gomez-Roca et al. ANNALS OF ONCOLOGY
- Exosome-Mediated Metastasis: Communication from a Distance
- (2019) Inbal Wortzel et al. DEVELOPMENTAL CELL
- Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer‐associated fibroblasts
- (2019) Ahmed E. Hegab et al. JOURNAL OF PATHOLOGY
- Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
- (2019) Deepali V. Sawant et al. NATURE IMMUNOLOGY
- Rational design of anti-GITR-based combination immunotherapy
- (2019) Roberta Zappasodi et al. NATURE MEDICINE
- Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
- (2019) Maisa C. Takenaka et al. NATURE NEUROSCIENCE
- PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
- (2019) Takahiro Kamada et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth
- (2019) Giulia Biffi et al. Cancer Discovery
- CCL2/CCR2 Axis Promotes the Progression of Salivary Adenoid Cystic Carcinoma via Recruiting and Reprogramming the Tumor-Associated Macrophages
- (2019) Zihui Yang et al. Frontiers in Oncology
- Catecholamines contribute to the neovascularization of lung cancer via tumor-associated macrophages
- (2019) Yun Xia et al. BRAIN BEHAVIOR AND IMMUNITY
- Mesenchymal stem cell-mediated delivery of an oncolytic adenovirus enhances antitumor efficacy in hepatocellular carcinoma
- (2019) A-Rum Yoon et al. CANCER RESEARCH
- Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion
- (2019) Fengkai Li et al. CANCER RESEARCH
- Mesenchymal stem cell homing towards cancer cells is increased by enzyme activity of cathepsin D
- (2019) Gowthami Vangala et al. EXPERIMENTAL CELL RESEARCH
- Exosomes derived from microRNA-101-3p-overexpressing human bone marrow mesenchymal stem cells suppress oral cancer cell proliferation, invasion, and migration
- (2019) Chun Xie et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- A Phase I Study of Binimetinib (MEK162) Combined with Pexidartinib (PLX3397) in Patients with Advanced Gastrointestinal Stromal Tumor
- (2019) Evan Rosenbaum et al. ONCOLOGIST
- CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
- (2019) Luigi Racioppi et al. Nature Communications
- Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
- (2019) Ela Elyada et al. Cancer Discovery
- Mesenchymal stem cells confer chemoresistance in breast cancer via a CD9 dependent mechanism
- (2019) Mujib Ullah et al. Oncotarget
- Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B
- (2019) Radhakrishnan Vishnubalaji et al. Scientific Reports
- Emerging Role of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Pathogenesis of Haematological Malignancies
- (2019) Juçara Gastaldi Cominal et al. Stem Cells International
- Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells
- (2019) Catharina Melzer et al. Cancers
- Metastatic Latency, a Veiled Threat
- (2019) Kangsan Kim et al. Frontiers in Immunology
- Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
- (2018) Ana Costa et al. CANCER CELL
- Reprogramming tumor stroma using an endogenous lipid lipoxin A4 to treat pancreatic cancer
- (2018) Jonas Schnittert et al. CANCER LETTERS
- CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
- (2018) Shicheng Su et al. CELL
- Enhanced metastatic capacity of breast cancer cells after interaction and hybrid formation with mesenchymal stroma/stem cells (MSC)
- (2018) Catharina Melzer et al. Cell Communication and Signaling
- Novel effector phenotype of Tim-3+ regulatory T cells leads to enhanced suppressive function in head and neck cancer patients
- (2018) Zhuqing Liu et al. CLINICAL CANCER RESEARCH
- A peek into cancer-associated fibroblasts: origins, functions and translational impact
- (2018) Valerie S. LeBleu et al. Disease Models & Mechanisms
- Recent advances in the discovery of small molecule c-Met Kinase inhibitors
- (2018) Palak K. Parikh et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Complement 5a stimulates macrophage polarization and contributes to tumor metastases of colon cancer
- (2018) Chunmei Piao et al. EXPERIMENTAL CELL RESEARCH
- Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer
- (2018) Karin Binnemars-Postma et al. FASEB JOURNAL
- Fibroblast heterogeneity: implications for human disease
- (2018) Magnus D. Lynch et al. JOURNAL OF CLINICAL INVESTIGATION
- Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity
- (2018) Curtis J. Perry et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tumor Tolerance–Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin
- (2018) Francesco Marangoni et al. JOURNAL OF IMMUNOLOGY
- CYP4X1 Inhibition by Flavonoid CH625 Normalizes Glioma Vasculature through Reprogramming TAMs via CB2 and EGFR-STAT3 Axis
- (2018) Chenlong Wang et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
- (2018) Franck Pagès et al. LANCET
- CCL2/CCL5 secreted by the stroma induce IL-6/PYK2 dependent chemoresistance in ovarian cancer
- (2018) Jennifer Pasquier et al. Molecular Cancer
- Fatty acid oxidation contributes to IL-1β secretion in M2 macrophages and promotes macrophage-mediated tumor cell migration
- (2018) Qi Zhang et al. MOLECULAR IMMUNOLOGY
- Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death
- (2018) David Alfaro et al. Stem Cell Research & Therapy
- Macrophages and CD8 + T Cells Mediate the Antitumor Efficacy of Combined CD40 Ligation and Imatinib Therapy in Gastrointestinal Stromal Tumors
- (2018) Jennifer Q. Zhang et al. Cancer Immunology Research
- Paclitaxel reduces tumor growth by reprogramming tumor-associated macrophages to an M1- profile in a TLR4-dependent manner
- (2018) Carlos W Wanderley et al. CANCER RESEARCH
- Dual role of macrophage in tumor immunity
- (2018) Ryota Tamura et al. Immunotherapy
- Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci
- (2018) Virgínea de Araujo Farias et al. Molecular Cancer
- THE PROTEASE-DEPENDENT MESENCHYMAL MIGRATION OF TUMOR-ASSOCIATED MACROPHAGES AS A TARGET IN CANCER IMMUNOTHERAPY
- (2018) Philippe Gui et al. Cancer Immunology Research
- GITR Agonism Enhances Cellular Metabolism to Support CD8+ T-cell Proliferation and Effector Cytokine Production in a Mouse Tumor Model
- (2018) Simran S. Sabharwal et al. Cancer Immunology Research
- Anti-glucocorticoid-induced Tumor Necrosis Factor–Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects
- (2018) Jonathan E. Schoenhals et al. Frontiers in Immunology
- TLR9 agonist enhances radiofrequency ablation-induced CTL responses, leading to the potent inhibition of primary tumor growth and lung metastasis
- (2018) Aizhang Xu et al. Cellular & Molecular Immunology
- Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer
- (2018) Yael Raz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma
- (2018) Cindy Neuzillet et al. JOURNAL OF PATHOLOGY
- Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
- (2018) Zeli Yin et al. Molecular Cancer
- Targeting macrophages: therapeutic approaches in cancer
- (2018) Luca Cassetta et al. NATURE REVIEWS DRUG DISCOVERY
- Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growth
- (2018) Karen McLean et al. ONCOGENE
- Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
- (2018) Michael Bartoschek et al. Nature Communications
- DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death
- (2018) Benoît Thibault et al. Scientific Reports
- Targeting both tumour-associated CXCR2+neutrophils and CCR2+macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
- (2017) Timothy M Nywening et al. GUT
- Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression
- (2017) Yu Zhu et al. IMMUNITY
- Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors
- (2017) Frederick Arce Vargas et al. IMMUNITY
- TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action
- (2017) Wenwen Du et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer
- (2017) Chiara Berlato et al. JOURNAL OF CLINICAL INVESTIGATION
- Leptin receptor antagonism of iNKT cell function: a novel strategy to combat multiple myeloma
- (2017) M Favreau et al. LEUKEMIA
- Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies
- (2017) Elie Dheilly et al. MOLECULAR THERAPY
- Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
- (2017) Jennifer L. Guerriero et al. NATURE
- A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
- (2017) Anna Labernadie et al. NATURE CELL BIOLOGY
- Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas
- (2017) D Yan et al. ONCOGENE
- Biology of pancreatic stellate cells—more than just pancreatic cancer
- (2017) Pawel E. Ferdek et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis
- (2017) Peiwen Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Dual Role of Treg in Cancer
- (2017) M. Frydrychowicz et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent
- (2017) Alice O. Kamphorst et al. SCIENCE
- Human Placenta-Derived Mesenchymal Stromal-Like Cells Enhance Angiogenesis via T Cell-Dependent Reprogramming of Macrophage Differentiation
- (2017) Shuyang He et al. STEM CELLS
- Silencing of Foxp3 enhances the antitumor efficacy of GM-CSF genetically modified tumor cell vaccine against B16 melanoma
- (2017) Antonio Miguel et al. OncoTargets and Therapy
- Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance
- (2017) Xundong Wei et al. Cell Reports
- Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth
- (2017) Maria E. Gonzalez et al. Cell Reports
- Role of tumor microenvironment in tumorigenesis
- (2017) Maonan Wang et al. Journal of Cancer
- Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients
- (2016) Niels Halama et al. CANCER CELL
- Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth
- (2016) Lifeng Yang et al. Cell Metabolism
- Mesenchymal stromal cells and immunomodulation: A gathering of regulatory immune cells
- (2016) Mehdi Najar et al. CYTOTHERAPY
- Carcinoma-associated fibroblasts: orchestrating the composition of malignancy
- (2016) Philippe Gascard et al. GENES & DEVELOPMENT
- Improved Anti-Treg Vaccination Targeting Foxp3 Efficiently Decreases Regulatory T Cells in Mice
- (2016) Neda Mousavi Niri et al. JOURNAL OF IMMUNOTHERAPY
- Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
- (2016) Timothy M Nywening et al. LANCET ONCOLOGY
- PI3Kγ is a molecular switch that controls immune suppression
- (2016) Megan M. Kaneda et al. NATURE
- Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity
- (2016) Caroline Baer et al. NATURE CELL BIOLOGY
- Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers
- (2016) Takuro Saito et al. NATURE MEDICINE
- Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma
- (2016) Yuta Kondo et al. ORAL ONCOLOGY
- Bisphosphonates for cancer treatment: Mechanisms of action and lessons from clinical trials
- (2016) Heleen H. Van Acker et al. PHARMACOLOGY & THERAPEUTICS
- PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
- (2016) Weiping Zou et al. Science Translational Medicine
- Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease
- (2016) FuiBoon Kai et al. TRENDS IN CELL BIOLOGY
- Silencing of Foxp3 delays the growth of murine melanomas and modifies the tumor immunosuppressive environment
- (2016) Moisés Armides Franco-Molina et al. OncoTargets and Therapy
- IFN and CCL2 Cooperate to Redirect Tumor-Infiltrating Monocytes to Degrade Fibrosis and Enhance Chemotherapy Efficacy in Pancreatic Carcinoma
- (2016) K. B. Long et al. Cancer Discovery
- Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment
- (2016) Manuela Liguori et al. Oncotarget
- Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts
- (2016) Siham Moatassim-Billah et al. Oncotarget
- Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
- (2016) Anna-Maria Georgoudaki et al. Cell Reports
- Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells
- (2015) Elly De Vlieghere et al. BIOMATERIALS
- Macrophages and Therapeutic Resistance in Cancer
- (2015) Brian Ruffell et al. CANCER CELL
- Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer
- (2015) D. L. Moughon et al. CANCER RESEARCH
- Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients
- (2015) K. Kurose et al. CLINICAL CANCER RESEARCH
- Oral Debio1143 (AT406), an Antagonist of Inhibitor of Apoptosis Proteins, Combined With Daunorubicin and Cytarabine in Patients With Poor-Risk Acute Myeloid Leukemia—Results of a Phase I Dose-Escalation Study
- (2015) John F. DiPersio et al. Clinical Lymphoma Myeloma & Leukemia
- Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance
- (2015) C. Duluc et al. EMBO Molecular Medicine
- Phase I clinical study of the toll-like receptor 9 agonist MGN1703 in patients with metastatic solid tumours
- (2015) Martin R. Weihrauch et al. EUROPEAN JOURNAL OF CANCER
- Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer
- (2015) Daniel V.T. Catenacci et al. JOURNAL OF CLINICAL ONCOLOGY
- Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226
- (2015) Christopher A. Fuhrman et al. JOURNAL OF IMMUNOLOGY
- Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma
- (2015) Timothy J Underwood et al. JOURNAL OF PATHOLOGY
- CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study
- (2015) Philippe A Cassier et al. LANCET ONCOLOGY
- Toll-like receptor 7/8 agonist, R848, exhibits antitumoral effects in a breast cancer model
- (2015) TAO YIN et al. Molecular Medicine Reports
- Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
- (2015) Maria-Giuseppina Procopio et al. NATURE CELL BIOLOGY
- Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study
- (2015) Nicholas Butowski et al. NEURO-ONCOLOGY
- Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization
- (2015) Jason H. Stafford et al. NEURO-ONCOLOGY
- Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin
- (2015) H-Y Tan et al. Cell Death & Disease
- Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer
- (2015) Pamela Maris et al. PLOS MEDICINE
- Ontogeny of Tissue-Resident Macrophages
- (2015) Guillaume Hoeffel et al. Frontiers in Immunology
- Chemokine Receptor-Specific Antibodies in Cancer Immunotherapy: Achievements and Challenges
- (2015) Maria Vela et al. Frontiers in Immunology
- A phase I dose escalation study of oral c-MET inhibitor tivantinib (ARQ 197) in combination with gemcitabine in patients with solid tumors
- (2014) S. Pant et al. ANNALS OF ONCOLOGY
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy
- (2014) Carola H. Ries et al. CANCER CELL
- Antitumor activity and safety of combination therapy with the Toll-like receptor 9 agonist IMO-2055, erlotinib, and bevacizumab in advanced or metastatic non-small cell lung cancer patients who have progressed following chemotherapy
- (2014) David A. Smith et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- VISTA Regulates the Development of Protective Antitumor Immunity
- (2014) I. Le Mercier et al. CANCER RESEARCH
- Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages
- (2014) Yasutaka Okabe et al. CELL
- Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
- (2014) Mara H. Sherman et al. CELL
- Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses
- (2014) Nicole Joller et al. IMMUNITY
- Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
- (2014) Peter J. Murray et al. IMMUNITY
- Depletion of M2-Like Tumor-Associated Macrophages Delays Cutaneous T-Cell Lymphoma Development In Vivo
- (2014) Xuesong Wu et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
- (2014) Laura Bonapace et al. NATURE
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
- (2014) Khaled Ali et al. NATURE
- Remodelling the extracellular matrix in development and disease
- (2014) Caroline Bonnans et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo
- (2014) Nicholas M. Durham et al. PLoS One
- TGF-beta in CAF-mediated tumor growth and metastasis
- (2014) A. Calon et al. SEMINARS IN CANCER BIOLOGY
- LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer
- (2014) Jean Albrengues et al. Cell Reports
- Wound healing and the role of fibroblasts
- (2014) Bainbridge P. Journal of Wound Care
- AttenuatedListeria monocytogenesreprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis
- (2014) Patrick H Lizotte et al. OncoImmunology
- Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors
- (2013) Neta Erez et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Chemotherapeutic drug delivery to cancer cells using a combination of folate targeting and tumor microenvironment-sensitive polypeptides
- (2013) Wei Gao et al. BIOMATERIALS
- Role of Macrophage Targeting in the Antitumor Activity of Trabectedin
- (2013) Giovanni Germano et al. CANCER CELL
- A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors
- (2013) Shahneen K. Sandhu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- miR-142-3p Prevents Macrophage Differentiation during Cancer-Induced Myelopoiesis
- (2013) Nada Sonda et al. IMMUNITY
- BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression
- (2013) Aldo M. Roccaro et al. JOURNAL OF CLINICAL INVESTIGATION
- Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
- (2013) Tyler R. Simpson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Microenvironmental regulation of tumor progression and metastasis
- (2013) Daniela F Quail et al. NATURE MEDICINE
- CSF-1R inhibition alters macrophage polarization and blocks glioma progression
- (2013) Stephanie M Pyonteck et al. NATURE MEDICINE
- Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase
- (2013) N Weizman et al. ONCOGENE
- Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans
- (2013) D. Sugiyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MicroRNA-mediated control of macrophages and its implications for cancer
- (2013) Mario Leonardo Squadrito et al. TRENDS IN IMMUNOLOGY
- ‘Cancer associated fibroblasts’ – more than meets the eye
- (2013) Shalom Madar et al. TRENDS IN MOLECULAR MEDICINE
- Microenvironment mesenchymal cells protect ovarian cancer cell lines from apoptosis by inhibiting XIAP inactivation
- (2013) M Castells et al. Cell Death & Disease
- Concise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role?
- (2013) Jill Corre et al. Stem Cells Translational Medicine
- Host Responses in Tissue Repair and Fibrosis
- (2012) Jeremy S. Duffield et al. Annual Review of Pathology-Mechanisms of Disease
- Fibroblasts as architects of cancer pathogenesis
- (2012) Timothy Marsh et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Ovarian ascites-derived Hospicells promote angiogenesis via activation of macrophages
- (2012) Magali Castells et al. CANCER LETTERS
- Activation of Robo1 Signaling of Breast Cancer Cells by Slit2 from Stromal Fibroblast Restrains Tumorigenesis via Blocking PI3K/Akt/ -Catenin Pathway
- (2012) P.-H. Chang et al. CANCER RESEARCH
- Regulatory T-cell Modulation Using Cyclophosphamide in Vaccine Approaches: A Current Perspective
- (2012) D. T. Le et al. CANCER RESEARCH
- Macrophage-Induced Tumor Angiogenesis Is Regulated by the TSC2-mTOR Pathway
- (2012) W. Chen et al. CANCER RESEARCH
- T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development
- (2012) Naganari Ohkura et al. IMMUNITY
- Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer
- (2012) Kenneth J. Pienta et al. INVESTIGATIONAL NEW DRUGS
- Reprogramming of TAM toward proimmunogenic type through regulation of MAP kinases using a redox-active copper chelate
- (2012) P. Chakraborty et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Targeting Carcinoma-Associated Fibroblasts Within the Tumor Stroma With a Fibroblast Activation Protein-Activated Prodrug
- (2012) W. N. Brennen et al. JNCI-Journal of the National Cancer Institute
- Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature
- (2012) Qiong-wen Zhang et al. PLoS One
- CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients
- (2012) A. J. Rech et al. Science Translational Medicine
- Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
- (2011) D. A. Hume et al. BLOOD
- Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors
- (2011) Jens Rüter et al. CANCER BIOLOGY & THERAPY
- Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome
- (2011) Yingzi Ge et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
- (2011) Wei Zhu et al. CANCER LETTERS
- VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses
- (2011) Li Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- (2011) Bin-Zhi Qian et al. NATURE
- Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
- (2011) David G. DeNardo et al. Cancer Discovery
- Pancreatic cancer associated fibroblasts display normal allelotypes
- (2010) Kimberly Walter et al. CANCER BIOLOGY & THERAPY
- The extracellular matrix at a glance
- (2010) C. Frantz et al. JOURNAL OF CELL SCIENCE
- The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
- (2010) Taro Kawai et al. NATURE IMMUNOLOGY
- Methylation determines fibroblast activation and fibrogenesis in the kidney
- (2010) Wibke Bechtel et al. NATURE MEDICINE
- In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
- (2009) Marcin Kortylewski et al. NATURE BIOTECHNOLOGY
- A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
- (2009) Pierre Farmer et al. NATURE MEDICINE
- A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth
- (2009) Binzhi Qian et al. PLoS One
- Identification of Markers that Distinguish Monocyte-Derived Fibrocytes from Monocytes, Macrophages, and Fibroblasts
- (2009) Darrell Pilling et al. PLoS One
- Toward a genetics of cancer resistance
- (2009) George Klein PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation
- (2008) J. A. Bluestone et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling
- (2008) Ling Qiao et al. CANCER LETTERS
- Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages
- (2008) Koji Hiraoka et al. CANCER SCIENCE
- TGF-β: A Master of All T Cell Trades
- (2008) Ming O. Li et al. CELL
- Oncologic Trogocytosis of an Original Stromal Cells Induces Chemoresistance of Ovarian Tumours
- (2008) Arash Rafii et al. PLoS One
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