Balancing Selection Drives the Maintenance of Genetic Variation in Drosophila Antimicrobial Peptides

The genome of Drosophila innubila reveals lineage-specific patterns of selection in immune genes

(2019) Tom Hill et al.   MOLECULAR BIOLOGY AND EVOLUTION

Toll-Like Receptor Evolution in Birds: Gene Duplication, Pseudogenization, and Diversifying Selection

(2018) Hana Velová et al.   MOLECULAR BIOLOGY AND EVOLUTION

Rapid seasonal evolution in innate immunity of wild Drosophila melanogaster

(2018) Emily L. Behrman et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Signatures of balancing selection in toll-like receptor (TLRs) genes – novel insights from a free-living rodent

(2018) Agnieszka Kloch et al.   Scientific Reports

Toll-like receptor variation in the bottlenecked population of the Seychelles warbler: computer simulations see the ‘ghost of selection past’ and quantify the ‘drift debt’

(2017) D. L. Gilroy et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Detecting Long-Term Balancing Selection Using Allele Frequency Correlation

(2017) Katherine M. Siewert et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genetic architecture and balancing selection: the life and death of differentiated variants

(2017) Violaine Llaurens et al.   MOLECULAR ECOLOGY

An intimate link between antimicrobial peptide sequence diversity and binding to essential components of bacterial membranes

(2016) Paulina Schmitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Immune genes and divergent antimicrobial peptides in flies of the subgenus Drosophila

(2016) Mark A. Hanson et al.   BMC EVOLUTIONARY BIOLOGY

Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication

(2016) Ming-Shan Wang et al.   CELL RESEARCH

Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila

(2016) Robert L. Unckless et al.   CURRENT BIOLOGY

Survey of Global Genetic Diversity Within the Drosophila Immune System

(2016) Angela M. Early et al.   GENETICS

Increased alpha-defensin expression is associated with risk of coronary heart disease: a feasible predictive inflammatory biomarker of coronary heart disease in hyperlipidemia patients

(2016) Yaowapa Maneerat et al.   Lipids in Health and Disease

The Evolution of Innate Immune Genes: Purifying and Balancing Selection on β-Defensins in Waterfowl

(2016) Joanne R. Chapman et al.   MOLECULAR BIOLOGY AND EVOLUTION

A Thousand Fly Genomes: An ExpandedDrosophilaGenome Nexus

(2016) Justin B. Lack et al.   MOLECULAR BIOLOGY AND EVOLUTION

The potential for adaptive maintenance of diversity in insect antimicrobial peptides

(2016) Robert L. Unckless et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cytokine Diedel and a viral homologue suppress the IMD pathway inDrosophila

(2016) Olivier Lamiable et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balancing selection on immunity genes: review of the current literature and new analysis in Drosophila melanogaster

(2016) Myriam Croze et al.   ZOOLOGY

Survey of Global Genetic Diversity Within the Drosophila Immune System

(2016) Angela M. Early et al.   GENETICS

Footprints of ancient-balanced polymorphisms in genetic variation data from closely related species

(2015) Ziyue Gao et al.   EVOLUTION

Contrasted patterns of variation and evolutionary convergence at the antiviral OAS1 gene in old world primates

(2015) Ian Fish et al.   IMMUNOGENETICS

Immunogenetic heterogeneity in a widespread ungulate: the European roe deer (Capreoluscapreolus)

(2015) Erwan Quéméré et al.   MOLECULAR ECOLOGY

Trans-species polymorphism at antimicrobial innate immunity cathelicidin genes of Atlantic cod and related species

(2015) Katrín Halldórsdóttir et al.   PeerJ

Balancing Selection Is the Main Force Shaping the Evolution of Innate Immunity Genes

(2014) A. Ferrer-Admetlla et al.   JOURNAL OF IMMUNOLOGY

Evidence for adaptation from standing genetic variation on an antimicrobial peptide gene in the musselMytilus edulis

(2014) Célia C. Gosset et al.   MOLECULAR ECOLOGY

Functional characterization of naturally occurring melittin peptide isoforms in two honey bee species, Apis mellifera and Apis cerana

(2014) Doori Park et al.   PEPTIDES

Fluctuating Selection Models and Mcdonald-Kreitman Type Analyses

(2014) Toni I. Gossmann et al.   PLoS One

A Model-Based Approach for Identifying Signatures of Ancient Balancing Selection in Genetic Data

(2014) Michael DeGiorgio et al.   PLoS Genetics

Background Selection as Baseline for Nucleotide Variation across the Drosophila Genome

(2014) Josep M. Comeron   PLoS Genetics

Genomic Evidence of Rapid and Stable Adaptive Oscillations over Seasonal Time Scales in Drosophila

(2014) Alan O. Bergland et al.   PLoS Genetics

Random fluctuation of selection coefficients and the extent of nucleotide variation in human populations

(2013) S. Miura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune genes undergo more adaptive evolution than non-immune system genes in Daphnia pulex

(2012) Seanna J McTaggart et al.   BMC EVOLUTIONARY BIOLOGY

Rapid genetic change underpins antagonistic coevolution in a natural host-pathogen metapopulation

(2012) Peter H. Thrall et al.   ECOLOGY LETTERS

Neutrality Tests for Sequences with Missing Data

(2012) L. Ferretti et al.   GENETICS

Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana

(2012) V. Nolte et al.   GENOME RESEARCH

Estimating Divergence Dates and Substitution Rates in the Drosophila Phylogeny

(2012) Darren J. Obbard et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evidence for selection at cytokine loci in a natural population of field voles (Microtus agrestis)

(2012) ANDREW K. TURNER et al.   MOLECULAR ECOLOGY

The Drosophila melanogaster Genetic Reference Panel

(2012) Trudy F. C. Mackay et al.   NATURE

Genome-Wide Fine-Scale Recombination Rate Variation in Drosophila melanogaster

(2012) Andrew H. Chan et al.   PLoS Genetics

Population Genomics of Sub-Saharan Drosophila melanogaster: African Diversity and Non-African Admixture

(2012) John E. Pool et al.   PLoS Genetics

Long-Term Balancing Selection at the Antiviral Gene OAS1 in Central African Chimpanzees

(2011) William Ferguson et al.   MOLECULAR BIOLOGY AND EVOLUTION

Molecular Evolution of the Toll-Like Receptor Multigene Family in Birds

(2011) M. Alcaide et al.   MOLECULAR BIOLOGY AND EVOLUTION

Locus-specific protocol for nine different innate immune genes (antimicrobial peptides: β-defensins) across passerine bird species reveals within-species coding variation and a case of trans-species polymorphisms

(2011) O. HELLGREN et al.   Molecular Ecology Resources

PoPoolation: A Toolbox for Population Genetic Analysis of Next Generation Sequencing Data from Pooled Individuals

(2011) Robert Kofler et al.   PLoS One

DendroPy: a Python library for phylogenetic computing

(2010) J. Sukumaran et al.   BIOINFORMATICS

Evolutionary Analysis and Expression Profiling of Zebra Finch Immune Genes

(2010) Robert Ekblom et al.   Genome Biology and Evolution

Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene

(2010) R. Cagliani et al.   HUMAN GENETICS

In vitro tests of natural allelic variation of innate immune genes (avian β-defensins) reveal functional differences in microbial inhibition

(2010) O. HELLGREN et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

The Differential Evolutionary Dynamics of Avian Cytokine and TLR Gene Classes

(2010) T. Downing et al.   JOURNAL OF IMMUNOLOGY

Antagonistic coevolution accelerates molecular evolution

(2010) Steve Paterson et al.   NATURE

Multiple reciprocal adaptations and rapid genetic change upon experimental coevolution of an animal host and its microbial parasite

(2010) R. D. Schulte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus

(2009) Tim Downing et al.   BMC EVOLUTIONARY BIOLOGY

Variations in the expressed antimicrobial peptide repertoire of northern leopard frog (Rana pipiens) populations suggest intraspecies differences in resistance to pathogens

(2009) Jacob A. Tennessen et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Contrasting evolution of diversity at two disease-associated chicken genes

(2009) Tim Downing et al.   IMMUNOGENETICS

Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions

(2009) Matteo Fumagalli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effective population size and patterns of molecular evolution and variation

(2009) Brian Charlesworth   NATURE REVIEWS GENETICS

Association of human cathelicidin (hCAP-18/LL-37) gene expression with cardiovascular disease risk factors

(2009) H. Benachour et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Environment can alter selection in host–parasite interactions

(2009) Justyna Wolinska et al.   TRENDS IN PARASITOLOGY

Quantifying Adaptive Evolution in the Drosophila Immune System

(2009) Darren J. Obbard et al.   PLoS Genetics

Directional and balancing selection in human beta-defensins

(2008) Edward J Hollox et al.   BMC EVOLUTIONARY BIOLOGY

Antimicrobial peptides and self-DNA in autoimmune skin inflammation

(2008) Michel Gilliet et al.   CURRENT OPINION IN IMMUNOLOGY

Long-Term Balancing Selection at the West Nile Virus Resistance Gene, Oas1b, Maintains Transspecific Polymorphisms in the House Mouse

(2008) W. Ferguson et al.   MOLECULAR BIOLOGY AND EVOLUTION

Balancing Selection at a Frog Antimicrobial Peptide Locus: Fluctuating Immune Effector Alleles?

(2008) J. A. Tennessen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Patterns of Positive Selection in Six Mammalian Genomes

(2008) Carolin Kosiol et al.   PLoS Genetics

The signature of long-standing balancing selection at the human defensin β-1 promoter

(2008) Rachele Cagliani et al.   GENOME BIOLOGY