MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of CH223191-Induced Mitochondrial Dysfunction on Its Aryl Hydrocarbon Receptor Agonistic and Antagonistic Activities

(2019) Afshin Mohammadi-Bardbori et al.   CHEMICAL RESEARCH IN TOXICOLOGY

IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis

(2019) Kumar S. Bishnupuri et al.   CANCER RESEARCH

Tumor-Repopulating Cells Induce PD-1 Expression in CD8 + T Cells by Transferring Kynurenine and AhR Activation

(2018) Yuying Liu et al.   CANCER CELL

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

(2018) Yann Cormerais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic alterations affecting the genes encoding the enzymes of the kynurenine pathway and their association with human diseases

(2018) Fanni A. Boros et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

(2018) Mariafrancesca Scalise et al.   Frontiers in Chemistry

Antidepressant effect of repeated ketamine administration on kynurenine pathway metabolites in patients with unipolar and bipolar depression

(2018) Yanling Zhou et al.   BRAIN BEHAVIOR AND IMMUNITY

The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells

(2018) M. Carmen Lafita-Navarro et al.   GENES & DEVELOPMENT

Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder

(2018) Yanling Zhou et al.   PSYCHONEUROENDOCRINOLOGY

Clinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer

(2017) Kosuke Toda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases

(2017) Michael D. Lovelace et al.   NEUROPHARMACOLOGY

Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

(2017) Ming Yue et al.   Cell Reports

Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells

(2016) Elina Timosenko et al.   CANCER RESEARCH

Bromodomain and Extraterminal Protein Inhibitor JQ1 Suppresses Thyroid Tumor Growth in a Mouse Model

(2016) Xuguang Zhu et al.   CLINICAL CANCER RESEARCH

CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis

(2016) Danay Cibrian et al.   NATURE IMMUNOLOGY

SLC7A5 Functions as a Downstream Target Modulated by CRKL in Metastasis Process of Gastric Cancer SGC-7901 Cells

(2016) Junqing Wang et al.   PLoS One

BET inhibitors in the treatment of hematologic malignancies: current insights and future prospects

(2016) Hidayatullah Munshi et al.   OncoTargets and Therapy

BET protein inhibitor JQ1 inhibits growth and modulates WNT signaling in mesenchymal stem cells

(2016) Saeed Alghamdi et al.   Stem Cell Research & Therapy

Mini-Gut Organoids: Reconstitution of the Stem Cell Niche

(2015) Shoichi Date et al.   Annual Review of Cell and Developmental Biology

Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity

(2015) J.J. Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy

(2015) L. Zhai et al.   CLINICAL CANCER RESEARCH

MYC and metabolism on the path to cancer

(2015) Annie L. Hsieh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers

(2015) Paolo Puccetti et al.   PLoS One

Quantitative Insight into the Design of Compounds Recognized by theL-Type Amino Acid Transporter 1 (LAT1)

(2014) Henna Ylikangas et al.   ChemMedChem

The role of IDO in brain tumor immunotherapy

(2014) Lijie Zhai et al.   JOURNAL OF NEURO-ONCOLOGY

Indoleamine 2,3-dioxygenase 1 is upregulated in activated microglia in mice cerebellum during acute viral encephalitis

(2014) Ayako Taguchi et al.   NEUROSCIENCE LETTERS

Involvement of the Kynurenine Pathway in Human Glioma Pathophysiology

(2014) Seray Adams et al.   PLoS One

Inhibitor of MYC identified in a Krohnke pyridine library

(2014) J. R. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Factor AHR Prevents the Differentiation of a Stage 3 Innate Lymphoid Cell Subset to Natural Killer Cells

(2014) Tiffany Hughes et al.   Cell Reports

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Therapeutic Strategies to Inhibit MYC

(2014) M. R. McKeown et al.   Cold Spring Harbor Perspectives in Medicine

Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health

(2014) Lorena Pochini et al.   Frontiers in Chemistry

Control of Vertebrate Development by MYC

(2013) P. J. Hurlin   Cold Spring Harbor Perspectives in Medicine

A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin

(2012) Nicole L. Baganz et al.   ACS Chemical Neuroscience

Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation

(2012) Guofeng Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Kynurenine Pathway in Brain Tumor Pathogenesis

(2012) S. Adams et al.   CANCER RESEARCH

Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells

(2012) Mitesh Patel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

CH223191 Is a Ligand-Selective Antagonist of the Ah (Dioxin) Receptor

(2010) Bin Zhao et al.   TOXICOLOGICAL SCIENCES

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA