Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches

High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library

(2018) Jun Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Adverse outcome pathway networks II: Network analytics

(2018) Daniel L. Villeneuve et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The affinity of transthyretin for T 3 or T 4 does not determine which form of the hormone accumulates in the choroid plexus

(2018) Samantha J. Richardson et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Moderate perinatal thyroid hormone insufficiency alters visual system function in adult rats

(2018) William K. Boyes et al.   NEUROTOXICOLOGY

Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists

(2018) Derik E. Haggard et al.   REPRODUCTIVE TOXICOLOGY

CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone

(2018) Suzy Markossian et al.   THYROID

Developmental Thyroid Hormone Insufficiency Induces a Cortical Brain Malformation and Learning Impairments: A Cross-Fostering Study

(2018) Katherine L O’Shaughnessy et al.   TOXICOLOGICAL SCIENCES

Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats

(2018) Corinne Haines et al.   TOXICOLOGY

The US Federal Tox21 Program: A strategic and operational plan for continued leadership

(2018) Russell Thomas   ALTEX-Alternatives to Animal Experimentation

A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function

(2018) A. Trubiroha et al.   Scientific Reports

Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10)

(2018) David S. Sharlin et al.   Scientific Reports

Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor

(2018) Jianqiang Yang et al.   Scientific Reports

Proteomic Biomarkers for Bisphenol A–Early Exposure and Women’s Thyroid Cancer

(2018) Ho-Sun Lee et al.   Cancer Research and Treatment

Regulation of T3 Availability in the Developing Brain: The Mouse Genetics Contribution

(2018) Sabine Richard et al.   Frontiers in Endocrinology

Specific alteration of gene expression profile in rats by treatment with thyroid toxicants that inhibit thyroid hormone synthesis

(2018) Ayako Ohara et al.   JOURNAL OF APPLIED TOXICOLOGY

An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos

(2018) Sergio Jarque et al.   PLoS One

Evaluating iodide recycling inhibition as a novel molecular initiating event for thyroid axis disruption in amphibians

(2018) Jennifer H Olker et al.   TOXICOLOGICAL SCIENCES

Thyroid hormone disruption in the fetal and neonatal rat: Predictive hormone measures and bioindicators of hormone action in the developing cortex

(2018) K L O’Shaughnessy et al.   TOXICOLOGICAL SCIENCES

Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases

(2018) Jennifer H Olker et al.   TOXICOLOGICAL SCIENCES

Application of Adverse Outcome Pathways to U.S. EPA’s Endocrine Disruptor Screening Program

(2017) Patience Browne et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Adult hippocampal neurogenesis is impaired by transient and moderate developmental thyroid hormone disruption

(2017) M.E. Gilbert et al.   NEUROTOXICOLOGY

On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity

(2017) Richard S. Judson et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop

(2017) Roland Buesen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework

(2017) Iman Hassan et al.   TOXICOLOGICAL SCIENCES

Uridine Diphosphate-Glucuronosyltransferase (UGT) 2B Subfamily Interspecies Differences in Carnivores

(2017) Takamitsu Kondo et al.   TOXICOLOGICAL SCIENCES

Screening the ToxCast Phase 1 Chemical Library for Inhibition of Deiodinase Type 1 Activity

(2017) Michael W Hornung et al.   TOXICOLOGICAL SCIENCES

Application of Gene Set Enrichment Analysis for Identification of Chemically-Induced, Biologically Relevant Transcriptomic Networks and Potential Utilization in Human Health Risk Assessment

(2017) Jeffry L. Dean et al.   TOXICOLOGICAL SCIENCES

High-Throughput H295R Steroidogenesis Assay: Utility as an Alternative and a Statistical Approach to Characterize Effects on Steroidogenesis

(2017) Derik E Haggard et al.   TOXICOLOGICAL SCIENCES

Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS)

(2017) Daniel R. Hallinger et al.   TOXICOLOGY IN VITRO

Application of a nonradioactive assay for high throughput screening for inhibition of thyroid hormone uptake via the transmembrane transporter MCT8

(2017) Hongyan Dong et al.   TOXICOLOGY IN VITRO

Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-Cas

(2017) Yuto Sakane et al.   Biology Open

Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances

(2017) Katherine K Coady et al.   Integrated Environmental Assessment and Management

Genome-wide identification of thyroid hormone receptor targets in the remodeling intestine during Xenopus tropicalis metamorphosis

(2017) Liezhen Fu et al.   Scientific Reports

Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part I: Fathead minnow

(2016) Krysta R. Nelson et al.   AQUATIC TOXICOLOGY

Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part II: Zebrafish

(2016) Evelyn Stinckens et al.   AQUATIC TOXICOLOGY

Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles

(2016) Rong-Lin Wang et al.   BMC GENOMICS

Development and Validation of a Computational Model for Androgen Receptor Activity

(2016) Nicole C. Kleinstreuer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Exposure to2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) alters thyroid hormone levels and thyroid hormone-regulated gene transcription in manila clam Ruditapes philippinarum

(2016) Ying Song et al.   CHEMOSPHERE

Mild Thyroid Hormone Insufficiency During Development Compromises Activity-Dependent Neuroplasticity in the Hippocampus of Adult Male Rats

(2016) M. E. Gilbert et al.   ENDOCRINOLOGY

Liganded Thyroid Hormone Receptors Transactivate the DNA Methyltransferase 3a Gene in Mouse Neuronal Cells

(2016) Yasuhiro Kyono et al.   ENDOCRINOLOGY

Xenobiotics Produce Distinct Metabolomic Responses in Zebrafish Larvae (Danio rerio)

(2016) Susie S. Y. Huang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Changes in the Metabolome in Response to Low-Dose Exposure to Environmental Chemicals Used in Personal Care Products during Different Windows of Susceptibility

(2016) Sander M. Houten et al.   PLoS One

Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals

(2016) Katherine E. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism

(2016) J. Patrizia Stohn et al.   PSYCHONEUROENDOCRINOLOGY

Effects of antiepileptic drug on thyroid hormones in patients with epilepsy: A meta-analysis

(2016) Yin-Xi Zhang et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

High-Throughput Screening of Chemical Effects on Steroidogenesis Using H295R Human Adrenocortical Carcinoma Cells

(2016) Agnes L. Karmaus et al.   TOXICOLOGICAL SCIENCES

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

(2016) Clemens Wittwehr et al.   TOXICOLOGICAL SCIENCES

Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

(2016) Katie Paul Friedman et al.   TOXICOLOGICAL SCIENCES

Effect of triclosan, triclocarban, 2,2′,4,4′-tetrabromodiphenyl ether, and bisphenol A on the iodide uptake, thyroid peroxidase activity, and expression of genes involved in thyroid hormone synthesis

(2016) Yuanfeng Wu et al.   TOXICOLOGY IN VITRO

Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization

(2016) Ruili Huang et al.   Nature Communications

ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance

(2016) I-Hsiao Chung et al.   Oncotarget

Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study

(2016) Tim I M Korevaar et al.   Lancet Diabetes & Endocrinology

“Stockpile” of Slight Transcriptomic Changes Determines the Indirect Genotoxicity of Low-Dose BPA in Thyroid Cells

(2016) Immacolata Porreca et al.   PLoS One

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

(2015) A. C. Gore et al.   ENDOCRINE REVIEWS

Thyroid Hormones and Moderate Exposure to Perchlorate during Pregnancy in Women in Southern California

(2015) Craig Steinmaus et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

(2015) Patience Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The Diversity of Mechanisms Influenced by Transthyretin in Neurobiology: Development, Disease and Endocrine Disruption

(2015) B. Alshehri et al.   JOURNAL OF NEUROENDOCRINOLOGY

Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals

(2015) Julie A. Bourdon-Lacombe et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases

(2015) Kostja Renko et al.   THYROID

In Vitro,Ex Vivo, andIn VivoDetermination of Thyroid Hormone Modulating Activity of Benzothiazoles

(2015) Michael W. Hornung et al.   TOXICOLOGICAL SCIENCES

Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action

(2015) April D. Lake et al.   TOXICOLOGICAL SCIENCES

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor

(2015) Richard S. Judson et al.   TOXICOLOGICAL SCIENCES

Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling

(2015) Lars Grøntved et al.   Nature Communications

Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening

(2014) Katie B. Paul et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Life Without the Iodothyronine Deiodinases

(2014) Valerie Anne Galton et al.   ENDOCRINOLOGY

Systematic Review and Evidence Integration for Literature-Based Environmental Health Science Assessments

(2014) Andrew A. Rooney et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling

(2014) Jonathan G. Boucher et al.   Obesity

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods

(2014) Regina Politi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vitro pituitary and thyroid cell proliferation assays and their relevance as alternatives to animal testing

(2014) Barae Jomaa   ALTEX-Alternatives to Animal Experimentation

Molecular target sequence similarity as a basis for species extrapolation to assess the ecological risk of chemicals with known modes of action

(2013) Carlie A. LaLone et al.   AQUATIC TOXICOLOGY

Impact of mild thyroid hormone deficiency in pregnancy on cognitive function in children: Lessons from the Generation R Study

(2013) Akhgar Ghassabian et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays

(2013) Nisha S. Sipes et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inhibition of Thyroid Hormone Sulfotransferase Activity by Brominated Flame Retardants and Halogenated Phenolics

(2013) Craig M. Butt et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Current Perspectives on the Use of Alternative Species in Human Health and Ecological Hazard Assessments

(2013) Edward J. Perkins et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Low Level Exposure to the Flame Retardant BDE-209 Reduces Thyroid Hormone Levels and Disrupts Thyroid Signaling in Fathead Minnows

(2013) Pamela D. Noyes et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Novel Mechanism of PositiveversusNegative Regulation by Thyroid Hormone Receptor β1 (TRβ1) Identified by Genome-wide Profiling of Binding Sites in Mouse Liver

(2013) Preeti Ramadoss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maternal Hypothyroxinemia in Early Pregnancy Predicts Reduced Performance in Reaction Time Tests in 5- to 6-Year-Old Offspring

(2013) Martijn J. J. Finken et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An Animal Model of Marginal Iodine Deficiency During Development: The Thyroid Axis and Neurodevelopmental Outcome*

(2013) Mary E. Gilbert et al.   TOXICOLOGICAL SCIENCES

Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat

(2013) Katie B. Paul et al.   TOXICOLOGY

Structure–activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity

(2013) Ryo Shimizu et al.   TOXICOLOGY

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

(2013) Katie B. Paul et al.   TOXICOLOGY IN VITRO

Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals

(2013) AlberTinka J. Murk et al.   TOXICOLOGY IN VITRO

Inhibition of the thyroid hormone pathway in Xenopus laevis by 2-mercaptobenzothiazole

(2012) Joseph E. Tietge et al.   AQUATIC TOXICOLOGY

The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation

(2012) Monica Dentice et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Transgenic zebrafish illuminate the dynamics of thyroid morphogenesis and its relationship to cardiovascular development

(2012) Robert Opitz et al.   DEVELOPMENTAL BIOLOGY

Identification of Iopanoic Acid as Substrate of Type 1 Deiodinase by a Novel Nonradioactive Iodide-Release Assay

(2012) Kostja Renko et al.   ENDOCRINOLOGY

Rodent Thyroid, Liver, and Fetal Testis Toxicity of the Monoester Metabolite of Bis-(2-ethylhexyl) Tetrabromophthalate (TBPH), a Novel Brominated Flame Retardant Present in Indoor Dust

(2012) Cecilia Springer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Assessment of the Binding of Hydroxylated Polybrominated Diphenyl Ethers to Thyroid Hormone Transport Proteins Using a Site-Specific Fluorescence Probe

(2012) Xiao M. Ren et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Update in TSH Receptor Agonists and Antagonists

(2012) Marvin C. Gershengorn et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Secretion and transfer of the thyroid hormone binding protein transthyretin by human placenta

(2012) R.H. Mortimer et al.   PLACENTA

New Approaches to Assess the Transthyretin Binding Capacity of Bioactivated Thyroid Hormone Disruptors

(2012) Mauricio Montaño et al.   TOXICOLOGICAL SCIENCES

Bisphenol A interferes with thyroid specific gene expression

(2012) Daniela Gentilcore et al.   TOXICOLOGY

Use of TSHβ:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals

(2012) Cheng Ji et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Xenobiotic Metabolomics: Major Impact on the Metabolome

(2011) Caroline H. Johnson et al.   Annual Review of Pharmacology and Toxicology

Maternal thyroid function in different conditions of iodine nutrition in pregnant women exposed to mild-moderate iodine deficiency: an observational study

(2011) Mariacarla Moleti et al.   CLINICAL ENDOCRINOLOGY

Conserved toxic responses across divergent phylogenetic lineages: a meta-analysis of the neurotoxic effects of RDX among multiple species using toxicogenomics

(2011) Natàlia Garcia-Reyero et al.   ECOTOXICOLOGY

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

(2011) Ruili Huang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Tyrosine Kinase Inhibitors Noncompetitively Inhibit MCT8-Mediated Iodothyronine Transport

(2011) Doreen Braun et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Thyroid hormones and fetal neurological development

(2011) J Patel et al.   JOURNAL OF ENDOCRINOLOGY

Endocrine disrupting properties of perfluorooctanoic acid

(2011) Sally S. White et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

A graphical systems model and tissue-specific functional gene sets to aid transcriptomic analysis of chemical impacts on the female teleost reproductive axis

(2011) Daniel L. Villeneuve et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Developmental thyroid hormone insufficiency reduces expression of brain-derived neurotrophic factor (BDNF) in adults but not in neonates

(2011) S.M. Lasley et al.   NEUROTOXICOLOGY AND TERATOLOGY

Halogenated Phenolic Contaminants Inhibit the In Vitro Activity of the Thyroid-Regulating Deiodinases in Human Liver

(2011) Craig M. Butt et al.   TOXICOLOGICAL SCIENCES

Third-Generation Ah Receptor–Responsive Luciferase Reporter Plasmids: Amplification of Dioxin-Responsive Elements Dramatically Increases CALUX Bioassay Sensitivity and Responsiveness

(2011) Guochun He et al.   TOXICOLOGICAL SCIENCES

Accumulation and Debromination of Decabromodiphenyl Ether (BDE-209) in Juvenile Fathead Minnows (Pimephales promelas) Induces Thyroid Disruption and Liver Alterations

(2011) Pamela D. Noyes et al.   TOXICOLOGICAL SCIENCES

Impact of Low-Level Thyroid Hormone Disruption Induced by Propylthiouracil on Brain Development and Function

(2011) Mary E. Gilbert   TOXICOLOGICAL SCIENCES

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

Iodine Deficiency in Pregnancy: The Effect on Neurodevelopment in the Child

(2011) Sheila Skeaff   Nutrients

Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis

(2010) Joseph E. Tietge et al.   AQUATIC TOXICOLOGY

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In vivo assessment and potential diagnosis of xenobiotics that perturb the thyroid pathway: Proteomic analysis of Xenopus laevis brain tissue following exposure to model T4 inhibitors

(2010) Jose Serrano et al.   Comparative Biochemistry and Physiology D-Genomics & Proteomics

Ontogenic expression profiles of thyroid-specific genes in embryonic and hatching chicks

(2010) S.V.H. Grommen et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

New Insights into Thyroid Hormone Action in the Developing Brain: The Importance of T3Degradation

(2010) R. Thomas Zoeller   ENDOCRINOLOGY

Type 3 Deiodinase Deficiency Causes Spatial and Temporal Alterations in Brain T3Signaling that Are Dissociated from Serum Thyroid Hormone Levels

(2010) Arturo Hernandez et al.   ENDOCRINOLOGY

Evaluation of the amphibian metamorphosis assay: Exposure to the goitrogen methimazole and the endogenous thyroid hormone L-thyroxine

(2010) Katherine Coady et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

(2010) Daniel M. Rotroff et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns

(2010) W. Edward Visser et al.   MOLECULAR ENDOCRINOLOGY

A possible mechanism for the decrease in serum thyroxine level by phenobarbital in rodents

(2010) Yoshihisa Kato et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay

(2010) Jaime Freitas et al.   TOXICOLOGY IN VITRO

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement

(2009) Evanthia Diamanti-Kandarakis et al.   ENDOCRINE REVIEWS

Life without Thyroxine to 3,5,3′-Triiodothyronine Conversion: Studies in Mice Devoid of the 5′-Deiodinases

(2009) Valerie Anne Galton et al.   ENDOCRINOLOGY

Nuclear Hormone Receptor Activity of Polybrominated Diphenyl Ethers and Their Hydroxylated and Methoxylated Metabolites in Transactivation Assays Using Chinese Hamster Ovary Cells

(2009) Hiroyuki Kojima et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers of Adverse Outcomes

(2009) Mark D. Miller et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In Vivo Acute Exposure to Polychlorinated Biphenyls: Effects on Free and Total Thyroxine in Rats

(2009) J. M. Hedge et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Carrier-Mediated Thyroid Hormone Transport into Placenta by Placental Transthyretin

(2009) Kelly A. Landers et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors

(2009) Changxue Lu et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Identification of Thyroid Hormone Receptor Binding Sites and Target Genes Using ChIP-on-Chip in Developing Mouse Cerebellum

(2009) Hongyan Dong et al.   PLoS One

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

(2009) S. Neumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interference of Endocrine Disrupters with Thyroid Hormone Receptor–Dependent Transactivation

(2009) Peter Josef Hofmann et al.   TOXICOLOGICAL SCIENCES

Competitive Binding of Poly- and Perfluorinated Compounds to the Thyroid Hormone Transport Protein Transthyretin

(2009) Jana M. Weiss et al.   TOXICOLOGICAL SCIENCES

Anti-thyroid hormone activity of bisphenol A, tetrabromobisphenol A and tetrachlorobisphenol A in an improved reporter gene assay

(2009) Hong Sun et al.   TOXICOLOGY IN VITRO

Environment and endocrinology: The case of thyroidology

(2008) J. Köhrle   ANNALES D ENDOCRINOLOGIE

Small-Molecule Inhibitors of Sodium Iodide Symporter Function

(2008) Nathalie Lecat-Guillet et al.   CHEMBIOCHEM

The Roles of Nuclear Receptors CAR and PXR in Hepatic Energy Metabolism

(2008) Yoshihiro Konno et al.   Drug Metabolism and Pharmacokinetics

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1

(2008) Balázs Gereben et al.   ENDOCRINE REVIEWS

Expression of the Thyroid Hormone Transporters Monocarboxylate Transporter-8 (SLC16A2) and Organic Ion Transporter-14 (SLCO1C1) at the Blood-Brain Barrier

(2008) Lori M. Roberts et al.   ENDOCRINOLOGY

3-Iodothyronamine (T1AM): A New Player on the Thyroid Endocrine Team?

(2008) Thomas S. Scanlan   ENDOCRINOLOGY

Competitive Inhibition of Organic Anion Transporting Polypeptide 1c1-Mediated Thyroxine Transport by the Fenamate Class of Nonsteroidal Antiinflammatory Drugs

(2008) Daniel E. Westholm et al.   ENDOCRINOLOGY

Developmental Exposure to Perchlorate Alters Synaptic Transmission in Hippocampus of the Adult Rat

(2008) Mary E. Gilbert et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

EFFECTS OF PERFLUOROOCTANE SULFONATE ON RAT THYROID HORMONE BIOSYNTHESIS AND METABOLISM

(2008) Wen-Guang Yu et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Effects of maternal exposure to ammonium perchlorate on thyroid function and the expression of thyroid-responsive genes in Japanese quail embryos

(2008) Yu Chen et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Thyroid disrupting chemicals: mechanisms and mixtures

(2008) Kevin M. Crofton   INTERNATIONAL JOURNAL OF ANDROLOGY

A Genomic Analysis of Subclinical Hypothyroidism in Hippocampus and Neocortex of the Developing Rat Brain

(2008) J. E. Royland et al.   JOURNAL OF NEUROENDOCRINOLOGY

Neurodevelopmental and Neurophysiological Actions of Thyroid Hormone

(2008) G. R. Williams   JOURNAL OF NEUROENDOCRINOLOGY

A Virtual Screen for Diverse Ligands: Discovery of Selective G Protein-Coupled Receptor Antagonists

(2008) Stanislav Engel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors

(2008) Sergei Romanov et al.   NATURE METHODS

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

The Changing Role of Maternal Thyroid Hormone in Fetal Brain Development

(2008) Gabriella Morreale de Escobar et al.   SEMINARS IN PERINATOLOGY

Effects of Perinatal PBDE Exposure on Hepatic Phase I, Phase II, Phase III, and Deiodinase 1 Gene Expression Involved in Thyroid Hormone Metabolism in Male Rat Pups

(2008) David T. Szabo et al.   TOXICOLOGICAL SCIENCES

Biosensor discovery of thyroxine transport disrupting chemicals

(2008) Gerardo R. Marchesini et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener

(2007) Vicki M. Richardson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY