Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action

Scientific and Regulatory Policy Committee (SRPC) Review*

(2015) Charles E. Wood et al.   TOXICOLOGIC PATHOLOGY

The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events

(2014) Ted W. Simon et al.   CRITICAL REVIEWS IN TOXICOLOGY

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

(2014) Knut Erik Tollefsen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Comparative Time Course Profiles of Phthalate Stereoisomers in Mice

(2014) Charles E. Wood et al.   TOXICOLOGICAL SCIENCES

Characterization of Nuclear Receptor-Mediated Murine Hepatocarcinogenesis of the Herbicide Pronamide and Its Human Relevance

(2014) Matthew J. LeBaron et al.   TOXICOLOGICAL SCIENCES

Dose-Response Modeling of Early Molecular and Cellular Key Events in the CAR-Mediated Hepatocarcinogenesis Pathway

(2014) David R. Geter et al.   TOXICOLOGICAL SCIENCES

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

(2013) J. Christopher Corton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

(2013) Clifford R. Elcombe et al.   CRITICAL REVIEWS IN TOXICOLOGY

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

(2013) M. E. Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

Biological Networks for Predicting Chemical Hepatocarcinogenicity Using Gene Expression Data from Treated Mice and Relevance across Human and Rat Species

(2013) Reuben Thomas et al.   PLoS One

Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Concordance of Transcriptional and Apical Benchmark Dose Levels for Conazole-Induced Liver Effects in Mice

(2013) Virunya S. Bhat et al.   TOXICOLOGICAL SCIENCES

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study

(2012) Russell S. Thomas et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

(2010) Bob Thoolen et al.   TOXICOLOGIC PATHOLOGY

Approaches to advancing quantitative human health risk assessment of environmental chemicals in the post-genomic era

(2010) Weihsueh A. Chiu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): A novel signalling pathway sensitive to phthalates

(2009) Alexandre Eveillard et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of Peroxisome Proliferator–Activated Receptor α—Independent Effects of PPARα Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate also Activates the Constitutive-Activated Receptor

(2009) Hongzu Ren et al.   TOXICOLOGICAL SCIENCES