Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry

Illuminating the dark phosphoproteome

(2019) Elise J. Needham et al.   Science Signaling

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

(2018) Martin Whitham et al.   Cell Metabolism

AMPK in skeletal muscle function and metabolism

(2018) Rasmus Kjøbsted et al.   FASEB JOURNAL

Phosphorylation-mediated structural changes within the SOAR domain of stromal interaction molecule 1 enable specific activation of distinct Orai channels

(2018) Jill L. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replicability and Prediction: Lessons and Challenges from GWAS

(2018) Urko M. Marigorta et al.   TRENDS IN GENETICS

Gain-of-function mutations in STIM1 and ORAI1 causing tubular aggregate myopathy and Stormorken syndrome

(2018) Johann Böhm et al.   CELL CALCIUM

ORAI1 Mutations with Distinct Channel Gating Defects in Tubular Aggregate Myopathy

(2017) Johann Böhm et al.   HUMAN MUTATION

A map of the phosphoproteomic alterations that occur after a bout of maximal-intensity contractions

(2017) Gregory K. Potts et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

(2017) Maximilian Kleinert et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Reactome Pathway Knowledgebase

(2017) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

(2017) Toby A. Dite et al.   Nature Communications

Omics and Exercise: Global Approaches for Mapping Exercise Biological Networks

(2017) Nolan J. Hoffman   Cold Spring Harbor Perspectives in Medicine

Molecular Basis for Exercise-Induced Fatigue: The Importance of Strictly Controlled Cellular Ca 2+ Handling

(2017) Arthur J. Cheng et al.   Cold Spring Harbor Perspectives in Medicine

STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca2+ Entry

(2017) Pascal Yazbeck et al.   Scientific Reports

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Trisulfate Disaccharide Decreases Calcium Overload and Protects Liver Injury Secondary to Liver Ischemia/Reperfusion

(2016) Enio Rodrigues Vasques et al.   PLoS One

STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration

(2015) Vanessa Casas-Rua et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications

(2015) Rima Chaudhuri et al.   BMC GENOMICS

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

(2015) Nolan J. Hoffman et al.   Cell Metabolism

The BioMart community portal: an innovative alternative to large, centralized data repositories

(2015) Damian Smedley et al.   NUCLEIC ACIDS RESEARCH

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

(2014) Louise Lantier et al.   FASEB JOURNAL

Enhanced Ca2+ influx from STIM1–Orai1 induces muscle pathology in mouse models of muscular dystrophy

(2014) Sanjeewa A. Goonasekera et al.   HUMAN MOLECULAR GENETICS

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)

(2014) Marc Fahrner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Store-operated Ca2+entry is not required for store refilling in skeletal muscle

(2013) Tanya R Cully et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Store-operated Ca2+Entry (SOCE) Induced by Protease-activated Receptor-1 Mediates STIM1 Protein Phosphorylation to Inhibit SOCE in Endothelial Cells through AMP-activated Protein Kinase and p38β Mitogen-activated Protein Kinase

(2013) Premanand C. Sundivakkam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function

(2013) Archana Jha et al.   JOURNAL OF CELL BIOLOGY

Initial Quantitative Proteomic Map of 28 Mouse Tissues Using the SILAC Mouse

(2013) Tamar Geiger et al.   MOLECULAR & CELLULAR PROTEOMICS

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Conformational dynamics of STIM1 activation

(2013) Stefan Feske et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Initial activation of STIM1, the regulator of store-operated calcium entry

(2013) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rapid Global Fitting of Large Fluorescence Lifetime Imaging Microscopy Datasets

(2013) Sean C. Warren et al.   PLoS One

Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue

(2013) Lan Wei-LaPierre et al.   Nature Communications

Effects of the Finnish Alzheimer Disease Exercise Trial (FINALEX)

(2013) Kaisu H. Pitkälä et al.   JAMA Internal Medicine

Systematic Functional Prioritization of Protein Posttranslational Modifications

(2012) Pedro Beltrao et al.   CELL

Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK

(2012) Florian Lang et al.   CELL CALCIUM

Rac1 Is a Novel Regulator of Contraction-Stimulated Glucose Uptake in Skeletal Muscle

(2012) L. Sylow et al.   DIABETES

Enhanced Ca2+ entry and Na+/Ca2+ exchanger activity in dendritic cells from AMP-activated protein kinase-deficient mice

(2012) Meerim K. Nurbaeva et al.   FASEB JOURNAL

TiSH — a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

(2012) Kasper Engholm-Keller et al.   Journal of Proteomics

Role of AMPK in pancreatic beta cell function

(2012) Accalia Fu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

(2012) Stefan M. Gehrig et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1

(2011) Sixin Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Targeting Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Preclinical Models Reveals a Potential Mechanism for the Treatment of Neuropathic Pain

(2011) Ohannes K Melemedjian et al.   Molecular Pain

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

AMP-activated protein kinase (AMPK)  1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

(2011) H. M. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans

(2010) Marie-Soleil Gauthier et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Starch Binding Domain-containing Protein 1/Genethonin 1 Is a Novel Participant in Glycogen Metabolism

(2010) Sixin Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

(2010) E. Pozo-Guisado et al.   JOURNAL OF CELL SCIENCE

Undesirable Charge-Enhancement of Isobaric Tagged Phosphopeptides Leads to Reduced Identification Efficiency

(2010) Tine E. Thingholm et al.   JOURNAL OF PROTEOME RESEARCH

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

Selective enrichment of sialic acid–containing glycopeptides using titanium dioxide chromatography with analysis by HILIC and mass spectrometry

(2010) Giuseppe Palmisano et al.   Nature Protocols

Toward the roles of store-operated Ca2+ entry in skeletal muscle

(2010) Bradley S. Launikonis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

ATP consumption by sarcoplasmic reticulum Ca2+ pumps accounts for 50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle

(2009) Sarah Michelle Norris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity

(2009) Narender Nath et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK and the biochemistry of exercise: implications for human health and disease

(2009) Erik A. Richter et al.   BIOCHEMICAL JOURNAL

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Abnormal calcium homeostasis in peripheral neuropathies

(2009) Paul Fernyhough et al.   CELL CALCIUM

Development of hepatic fibrosis occurs normally in AMPK-deficient mice

(2009) Alain Da Silva Morais et al.   CLINICAL SCIENCE

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions

(2009) T. K. O’Neil et al.   JOURNAL OF PHYSIOLOGY-LONDON

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

(2009) L. J. Holt et al.   SCIENCE

Weak functional constraints on phosphoproteomes

(2009) Christian R. Landry et al.   TRENDS IN GENETICS

Neuropathic pain: emerging treatments

(2008) A. Dray   BRITISH JOURNAL OF ANAESTHESIA

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation

(2008) Nicolas Dzamko et al.   JOURNAL OF PHYSIOLOGY-LONDON

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

BLOSUM62 miscalculations improve search performance

(2008) Mark P Styczynski et al.   NATURE BIOTECHNOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle

(2008) Jonathan Stiber et al.   NATURE CELL BIOLOGY