Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

Localization of mTORC2 activity inside cells

(2017) Michael Ebner et al.   JOURNAL OF CELL BIOLOGY

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

(2016) Lykke Sylow et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Exercise-stimulated glucose uptake — regulation and implications for glycaemic control

(2016) Lykke Sylow et al.   Nature Reviews Endocrinology

The Ca 2+ /Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft

(2016) Kathrina L. Marcelo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

(2016) Maximilian Kleinert et al.   Molecular Metabolism

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

(2015) Nolan J. Hoffman et al.   Cell Metabolism

mTORC2 is a tyrosine kinase

(2015) Xuemin Wang et al.   CELL RESEARCH

Regulation of Endothelial Cell Proliferation and Vascular Assembly through Distinct mTORC2 Signaling Pathways

(2015) Shan Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

(2015) P. Liu et al.   Cancer Discovery

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

(2015) Guang Yang et al.   Cell Reports

mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis

(2015) Meghan M. Morrison et al.   PLoS Genetics

The Molecular Basis for Load-Induced Skeletal Muscle Hypertrophy

(2014) George R. Marcotte et al.   CALCIFIED TISSUE INTERNATIONAL

Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle

(2014) M. Sato et al.   DIABETES

Rac1 - a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

(2014) Lykke Sylow et al.   EXPERIMENTAL PHYSIOLOGY

Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors

(2014) Dongjun Lee et al.   Stem Cell Reports

Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca2+ release

(2014) Thomas E. Jensen et al.   Molecular Metabolism

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

(2014) Maximilian Kleinert et al.   Molecular Metabolism

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

(2013) Dudley W. Lamming et al.   FASEB JOURNAL

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

(2013) Erik A. Richter et al.   PHYSIOLOGICAL REVIEWS

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rac1 Is a Novel Regulator of Contraction-Stimulated Glucose Uptake in Skeletal Muscle

(2012) L. Sylow et al.   DIABETES

TiSH — a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

(2012) Kasper Engholm-Keller et al.   Journal of Proteomics

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

(2011) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

(2011) Tim T. Chiu et al.   CELLULAR SIGNALLING

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

(2010) Won Jun Oh et al.   EMBO JOURNAL

A FOXO-Pak1 transcriptional pathway controls neuronal polarity

(2010) L. de la Torre-Ubieta et al.   GENES & DEVELOPMENT

Undesirable Charge-Enhancement of Isobaric Tagged Phosphopeptides Leads to Reduced Identification Efficiency

(2010) Tine E. Thingholm et al.   JOURNAL OF PROTEOME RESEARCH

Selective enrichment of sialic acid–containing glycopeptides using titanium dioxide chromatography with analysis by HILIC and mass spectrometry

(2010) Giuseppe Palmisano et al.   Nature Protocols

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

STIMulating store-operated Ca2+ entry

(2009) Michael D. Cahalan   NATURE CELL BIOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

Signal transducer and activator of transcription 5A/B in prostate and breast cancers

(2008) S.-H. Tan et al.   ENDOCRINE-RELATED CANCER

Phosphorylation of the JAK2-STAT5 Pathway in Response to Acute Aerobic Exercise

(2008) LESLIE A. CONSITT et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY