An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells

(2018) Luciano Castiello et al.   Cancer Immunology Research

Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies

(2018) Sandra Iurescia et al.   Frontiers in Immunology

Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers

(2018) David L Elion et al.   CANCER RESEARCH

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

(2017) David Olagnier et al.   MOLECULAR THERAPY

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

(2017) Alessandra Zevini et al.   TRENDS IN IMMUNOLOGY

Type I Interferon in Chronic Virus Infection and Cancer

(2017) Laura M. Snell et al.   TRENDS IN IMMUNOLOGY

Abstract B44: Selective stimulation of RIG-I with a novel synthetic RNA induces strong anti-tumor immunity in mouse tumor models

(2017) Jim Barsoum et al.   Cancer Immunology Research

Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance

(2017) Alessandra Zingoni et al.   Frontiers in Immunology

Tumor-derived factors modulating dendritic cell function

(2016) Jinbao Zong et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis

(2016) Saurabh Chattopadhyay et al.   IMMUNITY

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

(2016) Yuliya V. Katlinskaya et al.   Cell Reports

Role of type I interferon in inducing a protective immune response: Perspectives for clinical applications

(2015) Paola Rizza et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant

(2015) Vladimir Beljanski et al.   JOURNAL OF VIROLOGY

Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists

(2015) Cindy Chiang et al.   JOURNAL OF VIROLOGY

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8+ T cells

(2014) P Duewell et al.   CELL DEATH AND DIFFERENTIATION

New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape

(2014) Deepak Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Therapeutic Efficacy of Bifunctional siRNA Combining TGF- 1 Silencing with RIG-I Activation in Pancreatic Cancer

(2013) J. Ellermeier et al.   CANCER RESEARCH

MHC Class I Antigen Processing and Presenting Machinery: Organization, Function, and Defects in Tumor Cells

(2013) P. Leone et al.   JNCI-Journal of the National Cancer Institute

Targeting the Cytosolic Innate Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma

(2013) Martin Glas et al.   STEM CELLS

Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity

(2013) Marie-Line Goulet et al.   PLoS Pathogens

Innate immune sensing of cancer: clues from an identified role for type I IFNs

(2012) Thomas F. Gajewski et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses

(2012) S Bhattacharya et al.   ONCOGENE

Human NK cells in acute myeloid leukaemia patients: analysis of NK cell-activating receptors and their ligands

(2011) Beatriz Sanchez-Correa et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment

(2011) D. Levin et al.   MOLECULAR AND CELLULAR BIOLOGY

Inflammatory signaling compromises cell responses to interferon alpha

(2011) W-C HuangFu et al.   ONCOGENE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells

(2009) Robert Besch et al.   JOURNAL OF CLINICAL INVESTIGATION

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

(2008) Hendrik Poeck et al.   NATURE MEDICINE

Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis

(2008) T. L.-A. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA