Structure, dynamics and interactions of large SRP variants

Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions

(2019) Klemens Wild et al.   NUCLEIC ACIDS RESEARCH

Sequential activation of human signal recognition particle by the ribosome and signal sequence drives efficient protein targeting

(2018) Jae Ho Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex

(2018) Kan Kobayashi et al.   SCIENCE

The Escherichia coli SRP Receptor Forms a Homodimer at the Membrane

(2018) Georg Kempf et al.   STRUCTURE

Targeting and translocation of proteins to the endoplasmic reticulum at a glance

(2017) Naama Aviram et al.   JOURNAL OF CELL SCIENCE

Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond–like features

(2017) Raphael Carapito et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome

(2017) Ahmad Jomaa et al.   Nature Communications

The signal recognition particle contacts uL23 and scans substrate translation inside the ribosomal tunnel

(2017) Kärt Denks et al.   Nature Microbiology

Electrostatics and Intrinsic Disorder Drive Translocon Binding of the SRP Receptor FtsY

(2016) Nils-Alexander Lakomek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Archaeal Signal Recognition Particle: Present Understanding and Future Perspective

(2016) Sayandeep Gupta et al.   CURRENT MICROBIOLOGY

Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex

(2016) Klemens Wild et al.   JOURNAL OF MOLECULAR BIOLOGY

Cotranslational signal-independent SRP preloading during membrane targeting

(2016) Justin W. Chartron et al.   NATURE

Global profiling of SRP interaction with nascent polypeptides

(2016) Daniela Schibich et al.   NATURE

Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction

(2016) Matthias M. M. Becker et al.   NUCLEIC ACIDS RESEARCH

Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon

(2016) Ahmad Jomaa et al.   Nature Communications

Dynamics of co-translational protein targeting

(2015) Margaret M Elvekrog et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ribosome binding induces repositioning of the signal recognition particle receptor on the translocon

(2015) Patrick Kuhn et al.   JOURNAL OF CELL BIOLOGY

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

(2015) Bertrand Beckert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome–SRP–FtsY cotranslational targeting complex in the closed state

(2015) Ottilie von Loeffelholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Structure and Switch Cycle of SRβ as Ancestral Eukaryotic GTPase Associated with Secretory Membranes

(2015) Bhalchandra Jadhav et al.   STRUCTURE

Signal-sequence induced conformational changes in the signal recognition particle

(2015) Tobias Hainzl et al.   Nature Communications

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

(2015) Bhalchandra Jadhav et al.   Nature Communications

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

(2015) Bertrand Beckert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

(2015) Rebecca M Voorhees et al.   eLife

Fidelity of Cotranslational Protein Targeting by the Signal Recognition Particle

(2014) Xin Zhang et al.   Annual Review of Biophysics

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

Signal Recognition Particle-ribosome Binding Is Sensitive to Nascent Chain Length

(2014) Thomas R. Noriega et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of cargo recognition, commitment, and unloading drives cotranslational protein targeting

(2014) Ishu Saraogi et al.   JOURNAL OF CELL BIOLOGY

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo

(2014) Sebastian Pechmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

SRP RNA Remodeling by SRP68 Explains Its Role in Protein Translocation

(2014) J. T. Grotwinkel et al.   SCIENCE

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

Plasmodium falciparum signal recognition particle components and anti-parasitic effect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP

(2014) M Panchal et al.   Cell Death & Disease

mRNA-programmed translation pauses in the targeting of E. coli membrane proteins

(2014) Nir Fluman et al.   eLife

A Network of Cytosolic Factors Targets SRP-Independent Proteins to the Endoplasmic Reticulum

(2013) Tslil Ast et al.   CELL

Co-translational mechanisms of protein maturation

(2013) Felix Gloge et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular Mechanism of GTPase Activation at the Signal Recognition Particle (SRP) RNA Distal End

(2013) Kuang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SecYEG activates GTPases to drive the completion of cotranslational protein targeting

(2013) David Akopian et al.   JOURNAL OF CELL BIOLOGY

Translation- and SRP-independent mRNA targeting to the endoplasmic reticulum in the yeast Saccharomyces cerevisiae

(2013) Judith Kraut-Cohen et al.   MOLECULAR BIOLOGY OF THE CELL

The Structural Basis of FtsY Recruitment and GTPase Activation by SRP RNA

(2013) Felix Voigts-Hoffmann et al.   MOLECULAR CELL

SIMIBI twins in protein targeting and localization

(2013) Gert Bange et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Signal Recognition Particle RNA in Dinoflagellates and the Perkinsid Perkinsus marinus

(2013) Huan Zhang et al.   PROTIST

Exome Sequencing Identifies Autosomal-Dominant SRP72 Mutations Associated with Familial Aplasia and Myelodysplasia

(2012) Michael Kirwan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Novel Histone H4 Arginine 3 Methylation-sensitive Histone H4 Binding Activity and Transcriptional Regulatory Function for Signal Recognition Particle Subunits SRP68 and SRP72

(2012) Jingjing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic switch of the signal recognition particle from scanning to targeting

(2012) Wolf Holtkamp et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and Functional Discussion of the Tetra-Trico-Peptide Repeat, a Protein Interaction Module

(2012) Natalie Zeytuni et al.   STRUCTURE

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

(2011) Alfred Wittinghofer et al.   Annual Review of Biochemistry

Lipids Trigger a Conformational Switch That Regulates Signal Recognition Particle (SRP)-mediated Protein Targeting

(2011) Goran Stjepanovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of signal-sequence recognition by the signal recognition particle

(2011) Tobias Hainzl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the molecular evolution of SRP-GTPase activation by protein

(2011) Gert Bange et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct visualization reveals dynamics of a transient intermediate during protein assembly

(2011) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle

(2011) Rob W. van Nues et al.   RNA Biology

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

(2011) S. F. Ataide et al.   SCIENCE

Is there a twist in the Escherichia coli signal recognition particle pathway?

(2011) Eitan Bibi   TRENDS IN BIOCHEMICAL SCIENCES

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

(2011) Marta del Alamo et al.   PLOS BIOLOGY

Structural insights into the assembly of the human and archaeal signal recognition particles

(2010) Klemens Wild et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibitors of MAPK Pathway ERK1/2 or p38 Prevent the IL-1β-induced Up-regulation of SRP72 Autoantigen in Jurkat Cells

(2010) Victor E. Arana-Argáez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of a signal peptide by the signal recognition particle

(2010) Claudia Y. Janda et al.   NATURE

Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor

(2010) Leandro F Estrozi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting

(2010) Kuang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinship in the SRP RNA family

(2010) Magnus Alm Rosenblad et al.   RNA Biology

Structure of SRP14 from theSchizosaccharomyces pombesignal recognition particle

(2009) Mark A. Brooks et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Two Cooperating Helices Constitute the Lipid-binding Domain of the Bacterial SRP Receptor

(2009) David Braig et al.   JOURNAL OF MOLECULAR BIOLOGY

It takes two to tango: regulation of G proteins by dimerization

(2009) Raphael Gasper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Delivering proteins for export from the cytosol

(2009) Benedict C. S. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

(2009) Günter Kramer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multiple conformational switches in a GTPase complex control co-translational protein targeting

(2009) Xin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel

(2009) U. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the SRP68/72 interface of human signal recognition particle by systematic site-directed mutagenesis

(2009) Elena Iakhiaeva et al.   PROTEIN SCIENCE

Signal Sequences Activate the Catalytic Switch of SRP RNA

(2009) N. Bradshaw et al.   SCIENCE

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

(2009) T. Becker et al.   SCIENCE

SRP RNA controls a conformational switch regulating the SRP–SRP receptor interaction

(2008) Saskia B Neher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Signal sequence–independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel

(2008) Thomas Bornemann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of SRP54 and SRP19, the Two Proteins that Organize the Ribonucleic Core of the Signal Recognition Particle from Pyrococcus furiosus

(2008) Pascal F. Egea et al.   PLoS One

Structures of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus furiosus: Implications for the Targeting Step at the Membrane

(2008) Pascal F. Egea et al.   PLoS One