Fidelity of Cotranslational Protein Targeting by the Signal Recognition Particle

Signal Recognition Particle: An Essential Protein-Targeting Machine

(2013) David Akopian et al.   Annual Review of Biochemistry

The Cotranslational Function of Ribosome-Associated Hsp70 in Eukaryotic Protein Homeostasis

(2013) Felix Willmund et al.   CELL

Deubiquitinases Sharpen Substrate Discrimination during Membrane Protein Degradation from the ER

(2013) Zai-Rong Zhang et al.   CELL

SecYEG activates GTPases to drive the completion of cotranslational protein targeting

(2013) David Akopian et al.   JOURNAL OF CELL BIOLOGY

The Ribosome as a Hub for Protein Quality Control

(2013) Sebastian Pechmann et al.   MOLECULAR CELL

Structural basis of signal sequence surveillance and selection by the SRP–FtsY complex

(2013) Ottilie von Loeffelholz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The N-End Rule Pathway

(2012) Takafumi Tasaki et al.   Annual Review of Biochemistry

Mitochondrial protein import: Common principles and physiological networks

(2012) Jan Dudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cytosolic events involved in chloroplast protein targeting

(2012) Dong Wook Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

(2012) Onn Brandman et al.   CELL

Translation Elongation Regulates Substrate Selection by the Signal Recognition Particle

(2012) Dawei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Allostery of the Chaperonin GroEL

(2012) Helen R. Saibil et al.   JOURNAL OF MOLECULAR BIOLOGY

NAC functions as a modulator of SRP during the early steps of protein targeting to the endoplasmic reticulum

(2012) Ying Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Concerted Action of the Ribosome and the Associated Chaperone Trigger Factor Confines Nascent Polypeptide Folding

(2012) Anja Hoffmann et al.   MOLECULAR CELL

Activated GTPase movement on an RNA scaffold drives co-translational protein targeting

(2012) Kuang Shen et al.   NATURE

Dynamic switch of the signal recognition particle from scanning to targeting

(2012) Wolf Holtkamp et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Twin-arginine-dependent translocation of folded proteins

(2012) J. Frobel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Staying on message: ensuring fidelity in pre-mRNA splicing

(2012) Daniel R. Semlow et al.   TRENDS IN BIOCHEMICAL SCIENCES

Selective Ribosome Profiling Reveals the Cotranslational Chaperone Action of Trigger Factor In Vivo

(2011) Eugene Oh et al.   CELL

Site-Specific Fluorescent Labeling of Nascent Proteins on the Translating Ribosome

(2011) Ishu Saraogi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of signal-sequence recognition by the signal recognition particle

(2011) Tobias Hainzl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the molecular evolution of SRP-GTPase activation by protein

(2011) Gert Bange et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

(2011) Jens Frauenfeld et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct visualization reveals dynamics of a transient intermediate during protein assembly

(2011) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting

(2011) K. Shen et al.   RNA

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

(2011) S. F. Ataide et al.   SCIENCE

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

(2011) Marta del Alamo et al.   PLOS BIOLOGY

Cryo-electron microscopy of ribosomal complexes in cotranslational folding, targeting, and translocation

(2011) Kèvin Knoops et al.   Wiley Interdisciplinary Reviews-RNA

Recognition of nuclear targeting signals by Karyopherin-β proteins

(2010) Darui Xu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Lipid activation of the signal recognition particle receptor provides spatial coordination of protein targeting

(2010) Vinh Q. Lam et al.   JOURNAL OF CELL BIOLOGY

G domain dimerization controls dynamin's assembly-stimulated GTPase activity

(2010) Joshua S. Chappie et al.   NATURE

Recognition of a signal peptide by the signal recognition particle

(2010) Claudia Y. Janda et al.   NATURE

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor

(2010) Leandro F Estrozi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting

(2010) Kuang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting

(2010) X. Zhang et al.   SCIENCE

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

RNA polymerase fidelity and transcriptional proofreading

(2009) Jasmin F Sydow et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A trans-membrane segment inside the ribosome exit tunnel triggers RAMP4 recruitment to the Sec61p translocase

(2009) Martin R. Pool   JOURNAL OF CELL BIOLOGY

It takes two to tango: regulation of G proteins by dimerization

(2009) Raphael Gasper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Delivering proteins for export from the cytosol

(2009) Benedict C. S. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

(2009) Günter Kramer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multiple conformational switches in a GTPase complex control co-translational protein targeting

(2009) Xin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel

(2009) U. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal Sequences Activate the Catalytic Switch of SRP RNA

(2009) N. Bradshaw et al.   SCIENCE

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

(2009) T. Becker et al.   SCIENCE

SRP Keeps Polypeptides Translocation-Competent by Slowing Translation to Match Limiting ER-Targeting Sites

(2008) Asvin K.K. Lakkaraju et al.   CELL

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

Molecular mechanism and structure of Trigger Factor bound to the translating ribosome

(2008) Frieder Merz et al.   EMBO JOURNAL

Role of Protein Translocation Pathways across the Endoplasmic Reticulum inTrypanosoma brucei

(2008) Hanoch Goldshmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of a Multistep Mechanism for Assembly of the SRP·SRP Receptor Complex: Implications for the Catalytic Role of SRP RNA

(2008) Xin Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

A Cleavable N-Terminal Membrane Anchor is Involved in Membrane Binding of the Escherichia coli SRP Receptor

(2008) Benjamin Weiche et al.   JOURNAL OF MOLECULAR BIOLOGY

Quality control by the ribosome following peptide bond formation

(2008) Hani S. Zaher et al.   NATURE

SRP RNA controls a conformational switch regulating the SRP–SRP receptor interaction

(2008) Saskia B Neher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

(2008) Alice Y Yam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Signal sequence–independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel

(2008) Thomas Bornemann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformation of the signal recognition particle in ribosomal targeting complexes

(2008) I. A. Buskiewicz et al.   RNA

Protein Translocation Across the Bacterial Cytoplasmic Membrane

(2007) Arnold J.M. Driessen et al.   Annual Review of Biochemistry

Sec- and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—Distinct translocases and mechanisms

(2007) Paolo Natale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES