Targeting and translocation of proteins to the endoplasmic reticulum at a glance

hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells

(2017) Sarah Haßdenteufel et al.   FEBS LETTERS

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins

(2017) Arati Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calmodulin antagonist affects peroxisomal functionality by disrupting both peroxisomal Ca2+and protein import

(2017) Francisco J. Corpas et al.   JOURNAL OF CELL SCIENCE

Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins

(2017) Joseph Casson et al.   JOURNAL OF CELL SCIENCE

Mechanistic basis for a molecular triage reaction

(2017) Sichen Shao et al.   SCIENCE

Structural biology of the import pathways of peroxisomal matrix proteins

(2016) Leonidas Emmanouilidis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stress exposure results in increased peroxisomal levels of yeast Pnc1 and Gpd1, which are imported via a piggy-backing mechanism

(2016) Sanjeev Kumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Analysis of membrane proteins localizing to the inner nuclear envelope in living cells

(2016) Christine J. Smoyer et al.   JOURNAL OF CELL BIOLOGY

Pex9p is a novel yeast peroxisomal import receptor for PTS1-proteins

(2016) Daniel Effelsberg et al.   JOURNAL OF CELL SCIENCE

Characterization of proteome dynamics in oleate reveals a novel peroxisome targeting receptor

(2016) Eden Yifrach et al.   JOURNAL OF CELL SCIENCE

Structural Biology and Regulation of Protein Import into the Nucleus

(2016) Mary Christie et al.   JOURNAL OF MOLECULAR BIOLOGY

Cotranslational Intersection between the SRP and GET Targeting Pathways to the Endoplasmic Reticulum of Saccharomyces cerevisiae

(2016) Ying Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Once upon a Time – Chloroplast Protein Import Research from Infancy to Future Challenges

(2016) Bettina Bölter et al.   Molecular Plant

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

(2016) Naama Aviram et al.   NATURE

Cotranslational signal-independent SRP preloading during membrane targeting

(2016) Justin W. Chartron et al.   NATURE

Global profiling of SRP interaction with nascent polypeptides

(2016) Daniela Schibich et al.   NATURE

Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains

(2016) Bianca Schrul et al.   NATURE CELL BIOLOGY

Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets

(2016) Nora Kory et al.   TRENDS IN CELL BIOLOGY

The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding

(2015) Melissa A. Patterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Pex21p for Piggyback Import of Gpd1p and Pnc1p into Peroxisomes ofSaccharomyces cerevisiae

(2015) Daniel Effelsberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diffusion and retention are major determinants of protein targeting to the inner nuclear membrane

(2015) Rosemarie Ungricht et al.   JOURNAL OF CELL BIOLOGY

Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events

(2015) Brian J. Conti et al.   MOLECULAR CELL

Structure of the Get3 targeting factor in complex with its membrane protein cargo

(2015) A. Mateja et al.   SCIENCE

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Mechanisms Regulating Protein Localization

(2015) Nicholas C. Bauer et al.   TRAFFIC

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

(2015) Bhalchandra Jadhav et al.   Nature Communications

Ventromedial hypothalamic neurons control a defensive emotion state

(2015) Prabhat S Kunwar et al.   eLife

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease

(2014) Angelika B. Harbauer et al.   Cell Metabolism

The Back and Forth of Cargo Exit from the Endoplasmic Reticulum

(2014) Yosef Geva et al.   CURRENT BIOLOGY

Embracing the void—how much do we really know about targeting and translocation to the endoplasmic reticulum?

(2014) Naama Aviram et al.   CURRENT OPINION IN CELL BIOLOGY

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase

(2014) Fei Wang et al.   NATURE

Cotranslational folding inhibits translocation from within the ribosome–Sec61 translocon complex

(2014) Brian J Conti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon

(2014) Stefan Pfeffer et al.   Nature Communications

A Network of Cytosolic Factors Targets SRP-Independent Proteins to the Endoplasmic Reticulum

(2013) Tslil Ast et al.   CELL

Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway

(2013) Yuichi Yagita et al.   JOURNAL OF CELL BIOLOGY

Peroxisomes take shape

(2013) Jennifer J. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Precise timing of ATPase activation drives targeting of tail-anchored proteins

(2013) M. E. Rome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway

(2013) V. Denic et al.   Cold Spring Harbor Perspectives in Biology

Trafficking to uncharted territory of the nuclear envelope

(2012) Laura T Burns et al.   CURRENT OPINION IN CELL BIOLOGY

TRC40 can deliver short secretory proteins to the Sec61 translocon

(2012) N. Johnson et al.   JOURNAL OF CELL SCIENCE

Karyopherin-independent spontaneous transport of amphiphilic proteins through the nuclear pore

(2012) M. Kumeta et al.   JOURNAL OF CELL SCIENCE

Molecular Machinery for Insertion of Tail-Anchored Membrane Proteins into the Endoplasmic Reticulum Membrane in Mammalian Cells

(2012) Yasunori Yamamoto et al.   MOLECULAR CELL

Dynamic switch of the signal recognition particle from scanning to targeting

(2012) Wolf Holtkamp et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Calmodulin-Dependent Translocation Pathway for Small Secretory Proteins

(2011) Sichen Shao et al.   CELL

Preferential Targeting of a Signal Recognition Particle-dependent Precursor to the Ssh1p Translocon in Yeast

(2011) Michael P. Spiller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanism of membrane-associated steps in tail-anchored protein insertion

(2011) Malaiyalam Mariappan et al.   NATURE

Polypeptide binding specificities of Saccharomyces cerevisiae oligosaccharyltransferase accessory proteins Ost3p and Ost6p

(2011) M. Fairuz B. Jamaluddin et al.   PROTEIN SCIENCE

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

(2011) Marta del Alamo et al.   PLOS BIOLOGY

Fungal Secretome Database: Integrated platform for annotation of fungal secretomes

(2010) Jaeyoung Choi et al.   BMC GENOMICS

Structural Studies and the Assembly of the Heptameric Post-translational Translocon Complex

(2010) Yoichiro Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asna1/TRC40-mediated membrane insertion of tail-anchored proteins

(2010) V. Favaloro et al.   JOURNAL OF CELL SCIENCE

Peroxisomal Membrane Proteins Insert into the Endoplasmic Reticulum

(2010) Adabella van der Zand et al.   MOLECULAR BIOLOGY OF THE CELL

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms

(2010) Erik Wallin et al.   PROTEIN SCIENCE

Signal Recognition Particle (SRP) and SRP Receptor: A New Paradigm for Multistate Regulatory GTPases

(2009) Shu-ou Shan et al.   BIOCHEMISTRY

Cotranslational and Posttranslational N-Glycosylation of Polypeptides by Distinct Mammalian OST Isoforms

(2009) Catalina Ruiz-Canada et al.   CELL

A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel

(2009) U. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Hitchhiking of Cu/Zn Superoxide Dismutase to Peroxisomes - Evidence for a Natural Piggyback Import Mechanism in Mammals

(2009) Markus Islinger et al.   TRAFFIC

Peroxisomal Targeting of PTS2 Pre-Import Complexes in the YeastSaccharomyces cerevisiae

(2009) Silke Grunau et al.   TRAFFIC

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation

(2008) Ying Jiang et al.   JOURNAL OF CELL BIOLOGY

Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins

(2008) V. Favaloro et al.   JOURNAL OF CELL SCIENCE

Analysis of Glycosylation Site Occupancy Reveals a Role for Ost3p and Ost6p in Site-specificN-Glycosylation Efficiency

(2008) Benjamin L. Schulz et al.   MOLECULAR & CELLULAR PROTEOMICS