Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis

Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

(2014) Roy Emanuel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis

(2014) Ismail Sergin et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Interaction Domains of p62: A Bridge Between p62 and Selective Autophagy

(2013) Xiaolong Lin et al.   DNA AND CELL BIOLOGY

p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions

(2013) Yoshihisa Watanabe et al.   PLoS One

The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

(2013) K. Mori et al.   SCIENCE

Programmed Cell Death in Parkinson's Disease

(2013) K. Venderova et al.   Cold Spring Harbor Perspectives in Medicine

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

Mitochondria and Mitophagy

(2012) Dieter A. Kubli et al.   CIRCULATION RESEARCH

p62 Links β-adrenergic input to mitochondrial function and thermogenesis

(2012) Timo D. Müller et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Autophagy and Neuronal Cell Death in Neurological Disorders

(2012) R. A. Nixon et al.   Cold Spring Harbor Perspectives in Biology

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

(2011) Stefan Freigang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Protein aggregates in Huntington's disease

(2011) Montserrat Arrasate et al.   EXPERIMENTAL NEUROLOGY

Fatty Acid Synthase Modulates Homeostatic Responses to Myocardial Stress

(2011) Babak Razani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

(2011) Seth L. Masters et al.   TRENDS IN MOLECULAR MEDICINE

Alpha-1-Antitrypsin Deficiency: Importance of Proteasomal and Autophagic Degradative Pathways in Disposal of Liver Disease–Associated Protein Aggregates

(2010) David H. Perlmutter   Annual Review of Medicine

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection

(2010) Berenice Barajas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lysosomes, cholesterol and atherosclerosis

(2010) W Gray Jerome   Clinical Lipidology

Physiological significance of selective degradation of p62 by autophagy

(2010) Masaaki Komatsu et al.   FEBS LETTERS

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Autophagy and innate immunity: Triggering, targeting and tuning

(2010) Rhea Sumpter et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inclusion Body Myositis: A Degenerative Muscle Disease Associated with Intra-Muscle Fiber Multi-Protein Aggregates, Proteasome Inhibition, Endoplasmic Reticulum Stress and Decreased Lysosomal Degradation

(2009) Valerie Askanas et al.   BRAIN PATHOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Probing the interactions of the solvated electron with DNA by molecular dynamics simulations: bromodeoxyuridine substituted DNA

(2008) Tsvetan G. Gantchev et al.   JOURNAL OF MOLECULAR MODELING

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

(2008) J. Ramesh Babu et al.   JOURNAL OF NEUROCHEMISTRY

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

(2008) Thomas E. Sussan et al.   PLoS One

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

(2008) P. K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA