Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro

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(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

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SIRT3: A New Regulator of Cardiovascular Diseases

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Involvement of mitogen activated kinase kinase 7 intracellular signalling pathway in Sunitinib-induced cardiotoxicity

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SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway

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Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

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Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity

(2017) Songtao Li et al.   HEPATOLOGY

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

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Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma

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Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury

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(2016) Andrei S Chagin   CURRENT OPINION IN PHARMACOLOGY

Survival or death: a dual role for autophagy in stress-induced pericyte loss in diabetic retinopathy

(2016) Dongxu Fu et al.   DIABETOLOGIA

The tyrosine kinase inhibitor, sunitinib malate, induces cognitive impairment in vivo via dysregulating VEGFR signaling, apoptotic and autophagic machineries

(2016) Amal Kamal Abdel-Aziz et al.   EXPERIMENTAL NEUROLOGY

SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ROS Production

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Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway

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Cardiovascular events among 1090 cancer patients treated with sunitinib, interferon, or placebo: A comprehensive adjudicated database analysis demonstrating clinically meaningful reversibility of cardiac events

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HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS–JNK–autophagy pathway

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Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells

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Coronary Microvascular Pericytes Are the Cellular Target of Sunitinib Malate-Induced Cardiotoxicity

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Emerging beneficial roles of sirtuins in heart failure

(2012) Masaya Tanno et al.   BASIC RESEARCH IN CARDIOLOGY

Incidence and Risk of Congestive Heart Failure in Patients With Renal and Nonrenal Cell Carcinoma Treated With Sunitinib

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Autophagy plays an important role in Sunitinib-mediated cell death in H9c2 cardiac muscle cells

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Cardiovascular toxicity following sunitinib therapy in metastatic renal cell carcinoma: a multicenter analysis

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Electrocardiographic Characterization of the QTc Interval in Patients with Advanced Solid Tumors: Pharmacokinetic- Pharmacodynamic Evaluation of Sunitinib

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Sunitinib-Induced Cardiotoxicity Is Mediated by Off-Target Inhibition of AMP-Activated Protein Kinase

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Pyroptosis: host cell death and inflammation

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