Article
Cardiac & Cardiovascular Systems
Mayyasa Rammah, Magali Theveniau-Ruissy, Rachel Sturny, Francesca Rochais, Robert G. Kelly
Summary: This study reveals that the lipid sensor PPAR gamma is expressed in the future subpulmonary myocardium and is regulated by the transcription factor TBX1. Manipulating PPAR gamma activity through ex vivo cultured embryos and genetic deletion experiments shows that PPAR gamma is required for the addition of future subpulmonary myocardium and normal arterial pole development. Additionally, the non-canonical DLK1/NOTCH/HES1 pathway negatively regulates Ppar gamma in the future subaortic myocardium.
CIRCULATION RESEARCH
(2022)
Article
Hematology
Shengxu Li, Dave Watson, Alissa Jorgenson, Zainab Adelekan, Weihong Tang, Kathleen Garland, Leah Zupancich, David Dassenko, R. Erik Edens, David M. Overman, Marnie T. Huntley
Summary: This study identified novel circulating metabolites and metabolic pathways associated with thrombosis after cardiac surgery in children with congenital heart disease. The findings provide insights for further research and understanding of the mechanisms underlying thrombosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Anesthesiology
Ariane Willems, Renaud Havaux, Denis Schmartz, Jean-Francois Fils, Francoise De Pooter, Philippe Van Der Linden
Summary: This study examined the impact of two different inotropic regimens on postoperative morbidity and mortality in infants undergoing complex cardiac surgery. The results showed that the use of milrinone combined with epinephrine was associated with a higher incidence of postoperative morbidity or mortality compared to dobutamine.
MINERVA ANESTESIOLOGICA
(2023)
Article
Cardiac & Cardiovascular Systems
David F. A. Lloyd, Milou P. M. van Poppel, Kuberan Pushparajah, Trisha V. Vigneswaran, Vita Zidere, Johannes Steinweg, Joshua F. P. van Amerom, Thomas A. Roberts, Alexander Schulz, Marietta Charakida, Owen Miller, Gurleen Sharland, Mary Rutherford, Joseph Hajnal, John M. Simpson, Reza Razavi
Summary: Novel fetal MRI techniques provide a new way to understand and accurately predict severe neonatal CoA, with reduced blood flow through the left heart associated with important configurational changes at the aortic isthmus in fetal life, predisposing to CoA when the arterial duct closes after birth.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Linhong Song, Yi Wang, Hui Wang, Gang Wang, Ning Ma, Qiang Meng, Kunao Zhu, Siqi Hu, Gengxu Zhou, Zhichun Feng
Summary: This study retrospectively analyzed the clinical characteristics of CHD patients and provides important implications for therapeutic interventions. The medical records of CHD patients aged between 0 and 18 years were collected and analyzed. The most common CHD was congenital anomaly of a ventricle or the ventricular septum according to the International Classification of Diseases (ICD-11).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xuelian Yuan, Fengchao Liang, Jun Zhu, Keyong Huang, Li Dai, Xiaohong Li, Yanping Wang, Qi Li, Xiangfeng Lu, Jianfeng Huang, Lihui Liao, Yang Liu, Dongfeng Gu, Hanmin Liu, Fangchao Liu
Summary: This study investigated the association between maternal exposure to fine particulate matter (PM2.5) and fetal congenital heart defects (CHDs) in China. The results showed that higher maternal PM2.5 exposure, especially during the preconception period, increased the risk of certain types of CHDs in offspring. The findings highlight the importance of improving air quality in China and other highly polluted regions for CHD prevention.
Article
Cardiac & Cardiovascular Systems
Markus Schwerzmann, Francisco Javier Ruperti-Repilado, Helmut Baumgartner, Berto Bouma, Judith Bouchardy, Werner Budts, Laurence Campens, Massimo Chessa, Maria Jesus del Cerro Marin, Harald Gabriel, Pastora Gallego, Rocio Garcia-Orta, Ana Elvira Gonzalez, Annette Schophuus Jensen, Magalie Ladouceur, Berta Miranda-Barrio, Marielle Morissens, Agnes Pasquet, Joaquin Rueda, Annemien E. van den Bosch, Heleen Berdina van der Zwaan, Daniel Tobler, Matthias Greutmann
Summary: This study aimed to collect clinical outcome data and identify risk factors for a complicated course of COVID-19 in patients with adult congenital heart disease (ACHD). Risk factors such as age, obesity, and multiple comorbidities were associated with an increased risk of a complicated COVID-19 course in ACHD patients. Cyanotic heart disease, including unrepaired cyanotic defects or Eisenmenger syndrome, were identified as particularly high-risk congenital cardiac defects in ACHD patients.
Article
Pediatrics
Ping Ni, Mingjie Zhang, Yibei Wu, Wenyi Luo, Zhuoming Xu
Summary: Inadequate energy and protein supply in the acute postoperative period for children with CHD may be mainly caused by fluid restriction and fasting. Additionally, there is a moderate correlation between REE calculated by the Fick method and that estimated by the equation.
Article
Cardiac & Cardiovascular Systems
Carmen Leung, Anish Engineer, Mella Y. Kim, Xiangru Lu, Qingping Feng
Summary: The study generated a mouse model with cardiomyocyte-specific deletion of Rac1 during heart development, which resulted in disorganized cardiomyocytes, impaired growth, and a spectrum of congenital heart defects. This implicates Rac1 signaling in the ventricular myocardium as a crucial regulator of heart development.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Review
Cell Biology
Yuwen Chen, Deyong Xiao, Lu Zhang, Chen-Leng Cai, Bai-Yan Li, Ying Liu
Summary: Tbx20, a member of the T-box gene family, plays crucial roles in cardiovascular development and homeostasis, as well as cardiac remodeling in response to pathophysiological stresses. Mutations and genetic variants in TBX20 are associated with a wide spectrum of congenital heart defects and heart diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Health Care Sciences & Services
Olga Maria Diz, Rocio Toro, Sergi Cesar, Olga Gomez, Georgia Sarquella-Brugada, Oscar Campuzano
Summary: Congenital heart disease is a group of pathologies characterized by structural malformations of the heart or great vessels, with genetic variants playing a key role. High-throughput genetic technologies can help identify pathogenic factors. Early diagnosis and personalized treatment are crucial due to the high incidence and associated complications.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Danielle S. Burstein, Joseph W. Rossano, Heather Griffis, Xuemei Zhang, Rachel Fowler, Benjamin Frischertz, Yuli Y. Kim, JoAnn Lindenfield, Jeremy A. Mazurek, Jonathan B. Edelson, Jonathan N. Menachem
Summary: Limited contemporary data exist regarding outcomes and resource use among adults with congenital heart disease and heart failure. This study compared outcomes and resource use between adults with congenital heart disease and heart failure (ACHD-HF) and non-ACHD with heart failure (HF-non-ACHD). The study found that ACHD-HF patients have increased emergency department and hospital resource use over the past 10 years, but are less likely to receive advanced heart failure therapies such as ventricular assist device (VAD) or transplant compared with non-ACHD heart failure patients.
Article
Pediatrics
Bryanna N. Schwartz, Lisa A. Hom, Isabelle Von Kohorn, Jeffrey Becker, Sandra S. Cuzzi, Sue Ellin Grier Clarke, Sharon C. Kiernan, Gerard R. Martin
Summary: The study evaluated newborn pulse oximetry screening outcomes at a large community hospital and the impact of the recommended revised screening algorithm. Results showed that pulse oximetry screening is an effective tool for identifying critical congenital heart disease and other conditions.
Article
Biotechnology & Applied Microbiology
Ellen Garven, Christopher B. Rodell, Kristen Shema, Krianthan Govender, Samantha E. Cassel, Bryan Ferrick, Gabriella Kupsho, Ethan Kung, Kara L. Spiller, Randy Stevens, Amy L. Throckmorton
Summary: This study aims to address the high mortality rates in neonatal recipients of the Norwood procedure by developing a geometrically tunable blood shunt. Mathematical and computational models were utilized to determine the design criteria for shunt diameter changes. Through prototyping, responsive hydrogel systems were successfully designed and tested to allow for controlled modulation of blood flow. This research offers a new methodology to rebalance blood flow in vulnerable patients during growth and development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Critical Care Medicine
Daniel O. Hassumani, Mu Shan, Christopher W. Mastropietro, Sarah E. Wing, Matthew L. Friedman
Summary: Seizures are common in pediatric patients receiving ECMO for cardiac indications, with nearly one in five patients experiencing seizures. These seizures are often subclinical and can progress to status epilepticus, leading to longer ICU stays and poorer clinical outcomes in affected children.
NEUROCRITICAL CARE
(2022)
Article
Surgery
Daisy A. Elliott, Cynthia A. Ochieng, Jesmond Zahra, Angus G. K. G. McNair, Barry G. Main, Anni S. Skilton, Natalie S. Blencowe, Sian Cousins, Sangeetha Paramasivan, Christin L. Hoffmann, Jenny L. M. Donovan, Jane M. Blazeby, Lotus Clin Innovator Collaborators
Summary: This study investigated how information about innovative surgical procedures is communicated to patients. Through qualitative research on seven case studies in hospitals across the United Kingdom, interviews were conducted with clinician innovators, preoperative consultations were recorded, and postoperative interviews were conducted with patients. The study found inconsistencies between clinicians' intentions to inform patients about uncertain outcomes and their actual discussions with patients. Many patients were unaware of the unknown risks associated with the procedure.
Article
Medicine, General & Internal
Kurt Taylor, Robyn E. Wootton, Qian Yang, Sam Oddie, John Wright, Tiffany C. Yang, Maria Magnus, Ole A. Andreassen, Maria Carolina Borges, Massimo Caputo, Deborah A. Lawlor
Summary: This study used genetic epidemiology methods to explore the effects of maternal body mass index (BMI), smoking, and alcohol on offspring congenital heart diseases (CHDs). The results showed inconclusive associations between maternal BMI, smoking, alcohol, and offspring CHDs, indicating the need for further large-scale studies to replicate these findings.
Article
Cardiac & Cardiovascular Systems
Monica Cattaneo, Antonio P. Beltrami, Anita C. Thomas, Gaia Spinetti, Valeria Vincenza Alvino, Elisa Avolio, Claudia Veneziano, Irene Giulia Rolle, Sandro Sponga, Elena Sangalli, Anna Maciag, Fabrizio Dal Piaz, Carmine Vecchione, Aishah Alenezi, Stephen Paisey, Annibale A. Puca, Paolo Madeddu
Summary: The longevity-associated variant of the BPIFB4 gene, known as LAV-BPIFB4, can improve heart function and perfusion in older people, and prevent the decline of heart performance. Gene therapy with LAV-BPIFB4 can reverse the age-related decline in cardiac function, improve microvasculature density and pericyte coverage.
CARDIOVASCULAR RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Amy G. Harris, Tasneem Salih, Mohamed T. Ghorbel, Massimo Caputo, Giovanni Biglino, Michele Carrabba
Summary: Congenital heart disease is a common birth defect requiring invasive surgeries. The lack of growth and remodeling potential in current prosthetics limits their use in cardiovascular surgery. Tissue engineering aims to develop durable scaffolds that can grow and remodel in defective hearts. This review discusses existing biological scaffolds, including fixation and decellularization techniques, as well as cellularization methods for pediatric CHD treatment.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, General & Internal
Enoch F. Akowuah, Rebecca H. Maier, Helen C. Hancock, Ehsan Kharatikoopaei, Luke Vale, Cristina Fernandez-Garcia, Emmanuel Ogundimu, Janelle Wagnild, Ayesha Mathias, Zoe Walmsley, Nicola Howe, Adetayo Kasim, Richard Graham, Gavin J. Murphy, Joseph Zacharias
Summary: The safety and effectiveness of thoracoscopically-guided minithoracotomy compared with median sternotomy in mitral valve repair for patients with degenerative mitral valve regurgitation remain uncertain. This randomized trial aimed to compare the safety and effectiveness of minithoracotomy vs sternotomy in mitral valve repair. The results showed that minithoracotomy was not superior to sternotomy in physical function recovery at 12 weeks, but had similar safety outcomes at 1 year.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Sajad Hussain, Alexander G. Swystun, Massimo Caputo, Gianni D. Angelini, Hunaid A. Vohra
Summary: This study compared the outcomes between minimally invasive mitral valve surgery (MIMVS) and conventional sternotomy (CS) through a review and meta-analysis. The results showed that MIMVS was associated with lower risks of renal failure, new onset atrial fibrillation, mortality, and prolonged intubation compared to CS. Additionally, MIMVS had shorter ICU stay and time to discharge.
Article
Biotechnology & Applied Microbiology
Froso Sophocleous, Kiril Delchev, Estefania De Garate, Mark C. K. Hamilton, Massimo Caputo, Chiara Bucciarelli-Ducci, Giovanni Biglino
Summary: This study successfully applied 4D MRI technology to analyze arterial blood flow in 12 patients with bicuspid aortic valve (BAV) and 7 healthy controls. The results demonstrate the feasibility of studying wave propagation and reflection using this method, opening up possibilities for research applications in different cardiovascular scenarios.
BIOENGINEERING-BASEL
(2023)
Article
Cardiac & Cardiovascular Systems
Yue Gu, Elisa Avolio, Valeria V. Alvino, Anita C. Thomas, Andrew Herman, Poppy J. Miller, Niall Sullivan, Ashton Faulkner, Paolo Madeddu
Summary: The second-generation tyrosine kinase inhibitor dasatinib can reduce cardiac and bone marrow adiposity and improve cardiac function in obese, type 2 diabetic mice. These findings suggest that dasatinib may be a new treatment for diabetic cardiac steatosis.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cell Biology
Marston Bradshaw, John M. Squire, Edward Morris, Georgia Atkinson, Rebecca Richardson, Jon Lees, Massimo Caputo, Giulia M. Bigotti, Danielle M. Paul
Summary: This study used cryo-EM to investigate the three-dimensional structure of zebrafish cardiac thin and actin filaments, and found that they have the same fundamental organization as human reconstituted thin filaments. Zebrafish, as a model organism for human disease research, have similar genes and disease-causing genes to humans, making them suitable for studying human diseases.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2023)
Review
Cardiac & Cardiovascular Systems
Elisa Avolio, Paola Campagnolo, Rajesh Katare, Paolo Madeddu
Summary: Millions of cardiomyocytes die immediately after myocardial infarction, regardless of revascularization. Residual ischaemia in the peri-infarct zone causes further damage and a decline in function. Pericytes have crucial roles in angiogenesis, scar formation, inflammation control, and can be the target of various therapies to restore the perivascular niche after myocardial infarction.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Mai Baquedano, Samantha E. de Jesus, Filippo Rapetto, Gavin J. Murphy, Gianni Angelini, Umberto Benedetto, Patricia Caldas, Prashant K. Srivastava, Orhan Uzun, Karen Luyt, Cecilia Gonzalez Corcia, Demetris Taliotis, Serban Stoica, Deborah A. Lawlor, Andrew R. Bamber, Alison Perry, Katie L. Skeffington, Ikenna Omeje, John Pappachan, Andrew D. Mumford, Richard J. M. Coward, Damien Kenny, Massimo Caputo
Summary: This study aims to establish a prospective cohort of patients with congenital heart disease (CHD) undergoing cardiac procedures. It will collect clinical data, biological samples, and participant questionnaires to investigate risk factors, predictors, and the effects of surgery on outcomes.
Article
Medicine, General & Internal
Salvador Catsis, Alan R. Champneys, Rebecca Hoyle, Christine Currie, Jessica Enright, Katherine Cheema, Mike Woodall, Gianni Angelini, Ramesh Nadarajah, Chris Gale, Ben Gibbison
Summary: This study models the referral, diagnostic and treatment pathway for cardiovascular disease (CVD) in the English National Health Service (NHS) using a systems dynamics approach. The study uses routinely collected, publicly available data streams of primary and secondary care. The results show an increase in NHS CVD waiting lists in England, primarily due to restrictions in referrals from primary care.
Letter
Biochemistry & Molecular Biology
Elisa Avolio, Prashant K. Srivastava, Jiahui Ji, Michele Carrabba, Christopher T. W. Tsang, Yue Gu, Anita C. Thomas, Kapil Gupta, Imre Berger, Costanza Emanueli, Paolo Madeddu
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Miron Sopic, Emma L. Robinson, Costanza Emanueli, Prashant Srivastava, Claudio Angione, Carlo Gaetano, Gianluigi Condorelli, Fabio Martelli, Thierry Pedrazzini, Yvan Devaux
Summary: The field of epigenetics has gained attention in cardiovascular research due to its association with disease development. Multi-omics approaches that integrate different levels of disease regulation, such as DNA, histone, and RNA modifications, are essential for understanding complex diseases like cardiovascular diseases. This review focuses on discussing the role of epigenetic mechanisms in regulating gene expression and their interlinkage in the development of cardiac disease, particularly heart failure. The review also presents current methods and tools used for data integration and analysis, which can contribute to the discovery of novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.
BASIC RESEARCH IN CARDIOLOGY
(2023)