Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease
出版年份 2017 全文链接
标题
Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease
作者
关键词
α-synuclein, Iron, Dopamine, Endosomal trafficking, Oxidative stress, Post translational modification, N-terminal acetylation, Phosphorylation, Oxidation
出版物
Molecular Neurodegeneration
Volume 12, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-06-07
DOI
10.1186/s13024-017-0186-8
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
- (2017) Fabio A. Zucca et al. PROGRESS IN NEUROBIOLOGY
- Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations
- (2016) Igor Dikiy et al. ACS Chemical Biology
- Lysines, Achilles’ heel in alpha-synuclein conversion to a deadly neuronal endotoxin
- (2016) Nicoletta Plotegher et al. AGEING RESEARCH REVIEWS
- Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease
- (2016) Shounak Baksi et al. FREE RADICAL BIOLOGY AND MEDICINE
- The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure
- (2016) Aditya Iyer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
- (2016) Abdel A. Belaidi et al. JOURNAL OF NEUROCHEMISTRY
- Structural disorder of monomeric α-synuclein persists in mammalian cells
- (2016) Francois-Xavier Theillet et al. NATURE
- Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC
- (2016) Bruce Do Van et al. NEUROBIOLOGY OF DISEASE
- Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson’s Disease Stages?
- (2016) Lucie Hopes et al. PLoS One
- Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites
- (2016) Andres Binolfi et al. Nature Communications
- Dopamine Transporter Activity Is Modulated by α-Synuclein
- (2015) Brittany Butler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, andin Vivo
- (2015) Martial Kamdem Mbefo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Brain region-dependent differential expression of alpha-synuclein
- (2015) Katsutoshi Taguchi et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of -Amyloid Precursor Protein
- (2015) S. Ayton et al. JOURNAL OF NEUROSCIENCE
- Dopamine midbrain neurons in health and Parkinson’s disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels
- (2015) E. Dragicevic et al. NEUROSCIENCE
- DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity
- (2015) Patricia Muñoz et al. TOXICOLOGICAL SCIENCES
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
- (2015) Ulf Dettmer et al. Nature Communications
- Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event
- (2014) Jonas Kosten et al. ACS Chemical Neuroscience
- The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of -synuclein, and enhances its secretion and nuclear localization in cells
- (2014) M.-B. Fares et al. HUMAN MOLECULAR GENETICS
- In Vitro Phosphorylation Does not Influence the Aggregation Kinetics of WT α-Synuclein in Contrast to Its Phosphorylation Mutants
- (2014) Sarah Schreurs et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein
- (2014) Riccardo Porcari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Divergent effects of the H50Q and G51DSNCAmutations on the aggregation of α-synuclein
- (2014) Nicola J. Rutherford et al. JOURNAL OF NEUROCHEMISTRY
- Protective and toxic roles of dopamine in Parkinson's disease
- (2014) Juan Segura-Aguilar et al. JOURNAL OF NEUROCHEMISTRY
- Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
- (2014) K. J. Vargas et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner
- (2014) Guowei Yin et al. NEUROBIOLOGY OF DISEASE
- Diverse Metastable Structures Formed by Small Oligomers of α-Synuclein Probed by Force Spectroscopy
- (2014) Krishna Neupane et al. PLoS One
- Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers
- (2014) Georg Sebastian Nübling et al. PLoS One
- β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin
- (2014) Bruce X. Wong et al. PLoS One
- An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta
- (2014) Dominic J. Hare et al. Chemical Science
- Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration
- (2014) Scott Ayton et al. Biomed Research International
- Labile iron in cells and body fluids: physiology, pathology, and pharmacology
- (2014) Zvi Ioav Cabantchik Frontiers in Pharmacology
- Structures of the E46K Mutant-Type α-Synuclein Protein and Impact of E46K Mutation on the Structures of the Wild-Type α-Synuclein Protein
- (2013) Olivia Wise-Scira et al. ACS Chemical Neuroscience
- G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
- (2013) Suzanne Lesage et al. ANNALS OF NEUROLOGY
- Oxidative damage to macromolecules in human Parkinson disease and the rotenone model
- (2013) Laurie H. Sanders et al. FREE RADICAL BIOLOGY AND MEDICINE
- Parkinson disease: from pathology to molecular disease mechanisms
- (2013) David T. Dexter et al. FREE RADICAL BIOLOGY AND MEDICINE
- N-terminal Acetylation Stabilizes N-terminal Helicity in Lipid- and Micelle-bound α-Synuclein and Increases Its Affinity for Physiological Membranes
- (2013) Igor Dikiy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates
- (2013) Alexander S. Maltsev et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Site-Specific Perturbations of Alpha-Synuclein Fibril Structure by the Parkinson's Disease Associated Mutations A53T and E46K
- (2013) Luisel R. Lemkau et al. PLoS One
- Is R2* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up
- (2013) Miguel Ulla et al. PLoS One
- Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease
- (2012) Scott Ayton et al. ANNALS OF NEUROLOGY
- α-Synuclein knockout mice have cognitive impairments
- (2012) V.S. Kokhan et al. BEHAVIOURAL BRAIN RESEARCH
- Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties
- (2012) Alexander S. Maltsev et al. BIOCHEMISTRY
- Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context
- (2012) Vicente Sancenon et al. HUMAN MOLECULAR GENETICS
- α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer
- (2012) Bruno Fauvet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease
- (2012) David S. Goldstein et al. JOURNAL OF NEUROCHEMISTRY
- Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation
- (2012) M. J. Diogenes et al. JOURNAL OF NEUROSCIENCE
- Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
- (2012) Peng Lei et al. NATURE MEDICINE
- Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes
- (2012) Felix Schmidt et al. PLoS One
- Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene
- (2012) N. Jahanshad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impaired neurotransmission caused by overexpression of -synuclein in nigral dopamine neurons
- (2012) M. Lundblad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns
- (2012) Alicia Lundby et al. Cell Reports
- Phosphorylation of α-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of α-Synuclein in the Pathogenesis of Parkinson’s Disease and Related Disorders
- (2011) Yu Lu et al. ACS Chemical Neuroscience
- CSPα knockout causes neurodegeneration by impairing SNAP-25 function
- (2011) Manu Sharma et al. EMBO JOURNAL
- Synuclein modulation of monoamine transporters
- (2011) Adam W. Oaks et al. FEBS LETTERS
- Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes
- (2011) Naomi P. Visanji et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The alpha-synuclein 5′untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen
- (2011) Jack T. Rogers et al. JOURNAL OF NEURAL TRANSMISSION
- Iron Efflux from Oligodendrocytes Is Differentially Regulated in Gray and White Matter
- (2011) K. Schulz et al. JOURNAL OF NEUROSCIENCE
- Ceruloplasmin Oxidation, a Feature of Parkinson's Disease CSF, Inhibits Ferroxidase Activity and Promotes Cellular Iron Retention
- (2011) S. Olivieri et al. JOURNAL OF NEUROSCIENCE
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies
- (2010) Dalton James Surmeier et al. ANTIOXIDANTS & REDOX SIGNALING
- The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding
- (2010) Tim Bartels et al. BIOPHYSICAL JOURNAL
- Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
- (2010) James A. Duce et al. CELL
- The relevance of iron in the pathogenesis of Parkinson’s disease
- (2010) Jeswinder Sian-Hülsmann et al. JOURNAL OF NEUROCHEMISTRY
- Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions
- (2010) K. E. Paleologou et al. JOURNAL OF NEUROSCIENCE
- Exploring the Structural Details of Cu(I) Binding to α-Synuclein by NMR Spectroscopy
- (2010) Andres Binolfi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
- (2010) Venu M. Nemani et al. NEURON
- Iron Deficiency Anemia and Cognitive Function in Infancy
- (2010) R. C. Carter et al. PEDIATRICS
- -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
- (2010) B. Greten-Harrison et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells
- (2009) Bo Wu et al. ACTA HISTOCHEMICA
- Formation of dopamine-mediated α-synuclein-soluble oligomers requires methionine oxidation
- (2009) Su Ling Leong et al. FREE RADICAL BIOLOGY AND MEDICINE
- Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease
- (2009) Ning Song et al. FREE RADICAL BIOLOGY AND MEDICINE
- α-Synuclein Aggregation and Ser-129 Phosphorylation-dependent Cell Death in Oligodendroglial Cells
- (2009) Christine L. Kragh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents
- (2009) Songcang Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Binding of α-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes
- (2009) Yong Peng et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of α-Synuclein in a pH-Dependent Manner
- (2009) Chi L.L. Pham et al. JOURNAL OF MOLECULAR BIOLOGY
- Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson’s disease pathogenesis
- (2009) Kai-Yin Chau et al. JOURNAL OF NEUROCHEMISTRY
- Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons
- (2009) Eugene V. Mosharov et al. NEURON
- Iron, the substantia nigra and related neurological disorders
- (2008) Amanda M. Snyder et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Parkinson's disease: The syndrome, the pathogenesis and pathophysiology
- (2008) Anna L. Bartels et al. CORTEX
- Oligodendrocytes and myelination: The role of iron
- (2008) Bozho Todorich et al. GLIA
- Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein
- (2008) Katerina E. Paleologou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of α-Synuclein
- (2008) Elisa A. Waxman et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The phosphorylation state of Ser-129 in human -synuclein determines neurodegeneration in a rat model of Parkinson disease
- (2008) O. S. Gorbatyuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
- (2008) J. Salazar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started