Aging and Parkinson's disease: Different sides of the same coin?

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Interrogating the aged striatum: Robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration

(2015) Timothy J. Collier et al.   NEUROBIOLOGY OF DISEASE

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

(2015) Ulf Dettmer et al.   Nature Communications

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

(2011) P. Seibler et al.   JOURNAL OF NEUROSCIENCE

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

(2011) Timothy J. Collier et al.   NATURE REVIEWS NEUROSCIENCE

The aging striatal dopamine function

(2011) Olivier Darbin   PARKINSONISM & RELATED DISORDERS

Induced Pluripotent Stem Cells: Fundamentals and Applications of the Reprogramming Process and its Ramifications on Regenerative Medicine

(2011) Bhavita Walia et al.   Stem Cell Reviews and Reports

Age at onset: the major determinant of outcome in Parkinson's disease

(2010) M. A. Hely et al.   ACTA NEUROLOGICA SCANDINAVICA

Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism

(2010) Christin Glorioso et al.   NEUROBIOLOGY OF DISEASE

Modeling Parkinson's disease

(2009) C. Warren Olanow et al.   ANNALS OF NEUROLOGY

Lewy Body Pathology in Normal Elderly Subjects

(2009) William R. Markesbery et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Motor control and aging: Links to age-related brain structural, functional, and biochemical effects

(2009) Rachael D. Seidler et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: Relevance in selective neuronal vulnerability to degeneration

(2008) N. M. Kanaan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys

(2008) Nicholas M. Kanaan et al.   GLIA

Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys

(2008) Nicholas M. Kanaan et al.   NEUROBIOLOGY OF AGING