Transformable Nanoparticle‐Enabled Synergistic Elicitation and Promotion of Immunogenic Cell Death for Triple‐Negative Breast Cancer Immunotherapy

Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors

(2019) Xiaopin Duan et al.   Nature Communications

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

(2018) Jinyang Li et al.   IMMUNITY

Selective self-induced stimulus amplification prodrug platform for inhibiting multidrug resistance and lung metastasis

(2018) Chenfeng Xu et al.   JOURNAL OF CONTROLLED RELEASE

Micelle System Based on Molecular Economy Principle for Overcoming Multidrug Resistance and Inhibiting Metastasis

(2018) Yan Qi et al.   MOLECULAR PHARMACEUTICS

Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages

(2018) Bing He et al.   Nature Communications

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunotherapy in triple-negative breast cancer

(2017) Heather Katz et al.   MEDICAL ONCOLOGY

Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

(2017) Ping’an Ma et al.   NANO LETTERS

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

(2017) Jianqin Lu et al.   Nature Communications

Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy

(2016) Bing Feng et al.   ADVANCED FUNCTIONAL MATERIALS

Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin

(2016) Yang Wang et al.   Autophagy

Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy

(2016) Xiao Zhao et al.   BIOMATERIALS

Electrically Activated Primary Human Fibroblasts Improve In Vitro and In Vivo Skin Regeneration

(2016) Mahmoud Rouabhia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy

(2016) Cong Luo et al.   NANO LETTERS

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

(2016) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer

(2016) Haijun Yu et al.   Theranostics

5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers

(2016) Lauren Van Der Kraak et al.   Journal for ImmunoTherapy of Cancer

In Situ Formation of Nanofibers from Purpurin18-Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites

(2015) Di Zhang et al.   ADVANCED MATERIALS

Enzymatic Hydrogelation-Induced Fluorescence Turn-Off for Sensing Alkaline Phosphatase in Vitro and in Living Cells

(2015) Ling Dong et al.   ANALYTICAL CHEMISTRY

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor- B to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer

(2015) J. Peng et al.   CANCER RESEARCH

Cisplatin plus gemcitabine versus paclitaxel plus gemcitabine as first-line therapy for metastatic triple-negative breast cancer (CBCSG006): a randomised, open-label, multicentre, phase 3 trial

(2015) Xi-Chun Hu et al.   LANCET ONCOLOGY

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug-resistant cancer cells

(2015) Xu Li et al.   Journal of Materials Chemistry B

The Interplay of Immunotherapy and Chemotherapy: Harnessing Potential Synergies

(2015) Leisha A. Emens et al.   Cancer Immunology Research

Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents

(2014) Daniel Yuan Qiang Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cisplatin-Induced Antitumor Immunomodulation: A Review of Preclinical and Clinical Evidence

(2014) A. R. de Biasi et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: The Immunogenic Effects of Platinum-Based Chemotherapeutics

(2014) S. V. Hato et al.   CLINICAL CANCER RESEARCH

Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

(2014) B. M. Wolpin et al.   ONCOLOGIST

Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment

(2013) Zhou J. Deng et al.   ACS Nano

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

The additional facet of immunoscore: immunoprofiling as a possible predictive tool for cancer treatment

(2013) Paolo A Ascierto et al.   Journal of Translational Medicine

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

(2013) Rossella Marullo et al.   PLoS One

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Male contraceptive Adjudin is a potential anti-cancer drug

(2012) Qian Reuben Xie et al.   BIOCHEMICAL PHARMACOLOGY

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft

(2012) Kevin S. Chu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Primary Effusion Lymphoma Cell Death Induced by Bortezomib and AG 490 Activates Dendritic Cells through CD91

(2012) Mara Cirone et al.   PLoS One

Dasatinib as a Single Agent in Triple-Negative Breast Cancer: Results of an Open-Label Phase 2 Study

(2011) R. S. Finn et al.   CLINICAL CANCER RESEARCH

Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

(2011) W. Joost Lesterhuis et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of Immunogenic Apoptosis by Blockade of Epidermal Growth Factor Receptor Activation with a Specific Antibody

(2011) Greta Garrido et al.   JOURNAL OF IMMUNOLOGY

Antiangiogenic Antitumor Activity of HPMA Copolymer–Paclitaxel–Alendronate Conjugate on Breast Cancer Bone Metastasis Mouse Model

(2011) Keren Miller et al.   MOLECULAR PHARMACEUTICS

Melanoma drug wins US approval

(2011) Heidi Ledford   NATURE

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Improved Clinical Outcome in Indolent B-Cell Lymphoma Patients Vaccinated with Autologous Tumor Cells Experiencing Immunogenic Death

(2010) R. Zappasodi et al.   CANCER RESEARCH

The role of porphyrin chemistry in tumor imaging and photodynamic therapy

(2010) Manivannan Ethirajan et al.   CHEMICAL SOCIETY REVIEWS

Triple-Negative Breast Cancer

(2010) Shaheenah Dawood   DRUGS

Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

(2010) Daniel P. Silver et al.   JOURNAL OF CLINICAL ONCOLOGY

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Tumor-Associated Lymphocytes As an Independent Predictor of Response to Neoadjuvant Chemotherapy in Breast Cancer

(2009) Carsten Denkert et al.   JOURNAL OF CLINICAL ONCOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Cisplatin Ototoxicity and Protection: Clinical and Experimental Studies

(2009) Leonard P Rybak et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows

(2008) F. Gentile et al.   JOURNAL OF BIOMECHANICS

Adjudin-mediated germ cell depletion alters the anti-oxidant status of adult rat testis

(2008) Oli Sarkar et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT