Article
Biophysics
Daquan Wang, Na Zhou, Ning Zhang, Zhe Zhi, Yongping Shao, Lingjie Meng, Demei Yu
Summary: A novel redox/pH dual-responsive and biodegradable polyphosphazene (PPZ) nano-prodrugs have been prepared, which can achieve controlled drug release in tumor microenvironment, exhibit significant cytotoxicity to cancer cells, and have negligible side effects on normal cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Ji Luo, Shuguang Zhang, Peiyao Zhu, Wenke Liu, Jiang Du
Summary: In this study, pH/redox dual-responsive mixed polyprodrug micelles (MPPMs) were prepared for enhanced anticancer drug delivery. The MPPMs showed reasonable size and uniform dispersion, and exhibited pH and redox responsiveness. In vitro and in vivo experiments demonstrated that these MPPMs effectively released the drug and inhibited tumor growth, resulting in improved therapeutic efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lu Wang, Yunfeng Yan
Summary: RNA interference (RNAi) has potential in treating cancer and genetic disorders, but safe delivery methods remain a challenge. pH-responsive hybrid nanoparticles offer promise for siRNA delivery, with unique properties and potential benefits for therapeutic applications.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Polymer Science
Hung-Hsun Lu, Hsueh Wen Liu, Trinh Kieu Dinh, Cheng-Hung Huang, Hsi-Chien Huang, Ya-Ching Tseng, Man-Hsuan Ku, Fu-Sheng Wang, Yunching Chen, Chi-How Peng
Summary: The combination of chemotherapy and gene therapy is a versatile strategy for treating multi-drug-resistant cancer. Researchers have developed a pH-responsive triblock copolymeric carrier for delivering both chemotherapeutic and genetic drugs simultaneously.
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Chemistry, Applied
Min Mu, Xiaoyan Liang, Di Chuan, Shasha Zhao, Wei Yu, Rangrang Fan, Aiping Tong, Na Zhao, Bo Han, Gang Guo
Summary: The study successfully constructed a Cabazitaxel@MPN/CS delivery system, with good drug release and cellular internalization effects in melanoma therapy, providing a promising strategy for cancer treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Yunfei Yi, Mian Yu, Chan Feng, Huisong Hao, Weiwei Zeng, Chuchu Lin, Hongzhong Chen, Feng Lv, Dunwan Zhu, Xiaoyuan Ji, Lin Mei, Meiying Wu, Wei Tao
Summary: In this study, peptide-based siRNA nanomaterials were developed to enhance the efficacy of antitumor immunotherapy. These nanomaterials respond to the tumor microenvironment and enable precise drug delivery and release. Photodynamic therapy mediated by these nanomaterials can eliminate solid tumors and induce immunogenic cell death, generating systemic immune responses. Additionally, the normalization of tumor vasculature and the silencing of tumor cells' resistance to immune effector cells further strengthen the antitumor immunogenicity.
Article
Biophysics
Chong-Hua Zhang, Ke Cai, Peng-Ge Zhang, Zhan Wu, Ming Ma, Bo Chen
Summary: The novel cancer theragnostic nanoassembly developed has high biocompatibility, stability, and low toxicity, and can be rapidly activated by the tumor microenvironment for selective fluorescence imaging, chemotherapy, and chemoenzymatic therapy. It shows great potential in cancer diagnosis and efficient therapy.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Applied
Akram Rahmani, Salar Salmanipour, Yousef Nami, Hassan Zavvar Mousavi, Roya Salehi
Summary: Polymeric micelles produced from novel biodegradable pH-sensitive copolymers have been developed as drug delivery carriers for combination therapy of breast cancer. These micelles can co-deliver hydrophilic and hydrophobic drugs, leading to enhanced cytotoxicity and apoptosis in cancer cells.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Review
Chemistry, Multidisciplinary
Nayeon Kang, Subin Son, Sunhong Min, Hyunsik Hong, Chowon Kim, Jusung An, Jong Seung Kim, Heemin Kang
Summary: Ferroptosis, an iron-dependent programmed cell death mechanism, can be regulated by intracellular iron supplementation and glutathione synthesis inhibition. Utilizing various endogenous and exogenous stimuli, such as tumor microenvironment conditions and external energy sources, can provide precise control and controllability for ferroptosis-based cancer therapy. The utilization of dual stimuli provides a new direction for efficient cancer therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Engineering, Biomedical
Yu-Han Wen, Po-I Hsieh, Hsin-Cheng Chiu, Chil-Wei Chiang, Chun-Liang Lo, Yi-Ting Chiang
Summary: This study developed dual pH-sensitive and tumor microenvironment-active targeting micelles for combining immunotherapy and chemotherapy, which effectively inhibited tumor cell growth, exhibited high tumor accumulation, and reduced adverse effects in a mouse model.
MATERIALS TODAY BIO
(2022)
Article
Biotechnology & Applied Microbiology
He Wang, Wenwen Shi, Danning Zeng, Qiudi Huang, Jiacui Xie, Huaying Wen, Jinfang Li, Xiyong Yu, Linghao Qin, Yi Zhou
Summary: In this study, an acid-activated mitochondria-targeting and redox-responsive drug nanocarrier was constructed to deliver paclitaxel (PTX) for enhancing therapeutic efficacy in drug-resistant lung cancer. The nanocarrier demonstrated selective mitochondrial targeting and inhibition of P-glycoprotein activity, leading to the suppression of drug resistance and cancer metastasis. The promising results suggest that this nanocarrier represents a significant advancement in cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yu Wang, Qianmei Wang, Xiaowen Wang, Pu Yao, Qing Dai, Xiaowei Qi, Ming Yang, Xiao Zhang, Rong Huang, Jing Yang, Qian Wang, Peiyuan Xia, Dinglin Zhang, Fengjun Sun
Summary: A self-responsive nanomaterial capable of self-supplying reactive oxygen species (ROS) was developed to deliver immunogenic cell death (ICD) inducers. The nanomaterial showed significant potential in inhibiting tumor growth and metastasis, as well as improving the efficacy of immunotherapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Tae-Young Heo, Quan Truong Hoang, Thuy Giang Nguyen Cao, Seung-Hwan Oh, Moon-Chul Ryu, Min Suk Shim, Soo-Hyung Choi
Summary: This study synthesized block copoly-electrolytes containing a poly(ethylene oxide) neutral block and a cationic block, achieving safe and efficient delivery of siRNA. Optimizing the fraction of guanidinium groups enhanced cellular internalization and siRNA transfection, but also had a trade-off between cellular uptake and toxicity.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Yuseon Shin, Patihul Husni, Kioh Kang, Dayoon Lee, Sehwa Lee, Eunseong Lee, Yuseok Youn, Kyungtaek Oh
Summary: The combination of nanotechnology and chemotherapy has led to more effective drug design through the development of nanomaterial-based drug delivery systems, offering precise control over the release of therapeutics. Among these systems, photo-triggered and pH-induced delivery methods have been widely studied and are effective in targeting solid tumors.
Article
Chemistry, Multidisciplinary
Yuqi Wang, Honglei Xie, Yao Wu, Shuzhou Xu, Yongping Li, Jie Li, Xiaoxuan Xu, Siling Wang, Yaping Li, Zhiwen Zhang
Summary: In this study, a reduction-sensitive nitric oxide donor conjugate of furoxans-oxaliplatin was synthesized and a stroma-cell-accessible bioinspired lipoprotein system (S-LFO) was designed to facilitate CTL infiltration in tumors for anticancer immunotherapy. The S-LFO treatment promoted tumor vessel normalization, eliminated components of tumor stroma, increased the number of CD3(+)CD8(+) T cells, and facilitated their trafficking to cancer cell regions in tumors. Additionally, the combination of S-LFO with an antiprogrammed death ligand-1 showed therapeutic benefits of retarded tumor growth and extended survivals in three murine tumor models.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yaxin Cui, Tianyu Zhu, Xueyan Zhang, Jicong Chen, Fengying Sun, Youxin Li, Lesheng Teng
Summary: Protein-based drugs face challenges in maintaining activity during oral delivery. This study developed bifunctional oral lipid polymer hybrid nanoparticles to deliver superoxide dismutase (SOD) for ulcerative colitis (UC) treatment, showing promising results in enhancing drug absorption and therapeutic effect.
CHINESE CHEMICAL LETTERS
(2022)
Correction
Biochemistry & Molecular Biology
Xi Wang, Yarong Zhao, Shiyan Dong, Robert J. Lee, Dongsheng Yang, Huan Zhang, Lesheng Teng
Article
Chemistry, Multidisciplinary
Ting Wu, Tianqun Lang, Chao Zheng, Wenlu Yan, Yu Li, Runqi Zhu, Xin Huang, Huae Xu, Yaping Li, Qi Yin
Summary: In this study, a nanoparticle HDC-DM was prepared by coating red blood cell membrane onto a hybrid micelle consisting of prodrugs and an anti-metastasis agent. The combination of phototherapy, chemotherapy, and anti-metastatic therapy using HDC-DM showed promising results in treating TNBC, increasing drug concentration in tumors and promoting drug penetration and immunogenic cell death.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Xiangyu Li, Shixin Zhang, Miaomiao Zhang, Ge Li, Bo Yang, Xinyue Lu, Lesheng Teng, Youxin Li, Fengying Sun
Summary: A new method of treating rheumatoid arthritis (RA) was developed in this study, which involves a combination of multiple treatment regimens to compensate for the limitations of single therapy. The results showed that the method had high blood compatibility and ideal in vitro phototherapy effect, and exhibited a selective enrichment at the inflammatory site and demonstrated anti-RA efficacy in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Bo Hou, Jiayi Ye, Junhao Li, Zhiai Xu, Haijun Yu
Summary: Due to pathophysiological barriers, the immune-excluded tumors (IETs) have limited response to current immune blockade therapy. In this study, a clickable prodrug nanoplatform was proposed to enhance immunotherapy of IETs by improving intratumoral infiltration of cytotoxic T lymphocytes (CTLs). The nanoplatform consisted of acidity-activatable nanoparticles and sequentially activated in the tumor microenvironment to promote the regression of IETs.
Article
Chemistry, Multidisciplinary
Yun Zhu, Shunan Zhang, Yi Lai, Jiaxing Pan, Fangmin Chen, Tingting Wang, Fengyang Wang, Zhiai Xu, Wenjun Yang, Haijun Yu
Summary: This study presents a self-cooperative prodrug nanovesicle for highly tumor-specific chemoradiotherapy, which can target tumors efficiently and overcome immune evasion mechanisms.
Article
Chemistry, Physical
Yingjie Wang, Fangmin Chen, Huiling Zhou, Lujia Huang, Jiayi Ye, Xiaoying Liu, Weizhong Sheng, Weidong Gao, Haijun Yu, Feng Wang
Summary: This study reveals that a combination therapy of dihydroartemisinin (DHA) and RSL-3 can induce ferroptosis of pancreatic ductal adenocarcinoma (PDAC) tumor cells. Nanoparticles that can deliver DHA and RSL-3 are synthesized and shown to inhibit tumor growth effectively in mouse models. This study provides novel insights for the treatment of PDAC with ferroptosis-based immunotherapy.
Article
Nanoscience & Nanotechnology
Ge Li, Xinyue Lu, Shixin Zhang, Jingbo Zhang, Xiaoge Fu, Miaomiao Zhang, Lesheng Teng, Fengying Sun
Summary: Drug resistance in tumor treatment has always been a major challenge. Ferroptosis, a regulated form of cell death, shows promising clinical applications. However, the effectiveness of ferroptosis-inducing agents is often limited when used alone, and thus, synergistic therapy becomes a potential strategy to address this issue.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Weiqi Wang, Qiwen Zhu, Yilan Jin, Jing Gao, Jianan Li, Xiaohua Zheng, Weidong Gao, Madiha Saeed, Weizhong Sheng, Haijun Yu
Summary: This study reports a self-immolated nanoadjuvant that enhances the effectiveness of cancer vaccination immunotherapy. The nanoadjuvants accumulate at the tumor site and release immune activators and photosensitizers in a specific manner. By activating immune cells and inducing immunogenic cell death of tumor cells, this nanoadjuvant effectively inhibits tumor growth and generates sustained immunological memory in a mouse model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jiaxing Pan, Yi Lai, Shunan Zhang, Huijuan Zhang, Yiming Shan, Lujia Huang, Feng Wang, Haijun Yu, Leiming Xu, Zhiai Xu
Summary: The weak response of pancreatic cancer patients to immunotherapy is attributed to cancer-associated fibroblast-induced fibrosis and tumor cell-mediated T-cell exhaustion. A self-adaptive nanoregulator has been developed to intervene in tumor fibrosis and reverse T-cell exhaustion, providing a novel approach to enhance PDAC immunotherapy.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Ziwei Li, Songren Han, Guilin Cui, Beilin Xue, Jiaxin Li, Yuhong Man, Huan Zhang, Lesheng Teng
Summary: A folic acid-targeted drug delivery system based on liposomes (FA-LP-GCK) was developed to treat rheumatoid arthritis (RA). The FA-LP-GCK showed high stability, encapsulation efficiency, and demonstrated strong anti-inflammatory and therapeutic effects in both cell and animal experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Huijuan Zhang, Jiaxing Pan, Tingting Wang, Yi Lai, Xiaoying Liu, Fangmin Chen, Leiming Xu, Xiongwei Qu, Xiuli Hu, Haijun Yu
Summary: This study reported a dual-responsive and biodegradable polypeptide nanoparticle for combinatory chemotherapy and photodynamic therapy of breast cancer. The nanoparticle could be activated in the acidic environment to release drugs, inducing apoptosis in tumor cells and effectively inhibiting tumor growth and metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yi Lai, Yijing Dang, Qian Sun, Jiaxing Pan, Haijun Yu, Wen Zhang, Zhiai Xu
Summary: A novel Fe3O4 nanoparticle-conjugated MGO-activatable NIR-II fluorescent probe with enhanced BBB penetration and brain accumulation capability through T7 peptide is reported in this study, which can be used for MGO detection in AD.
Article
Chemistry, Multidisciplinary
Jiayi Ye, Bo Hou, Madiha Saeed, Zhiai Xu, Haijun Yu
Summary: The success of immunotherapy, particularly immune checkpoint blockade therapy, has been witnessed in the current era. However, the complex tumor microenvironment and the immune resistance of tumor cells often hinder the effectiveness of immunotherapy. In recent years, scientists have developed bioinspired nanotherapeutics to overcome cancer immune resistance and enhance immunotherapy. These nanotherapeutics can deliver immunotherapeutics specifically to tumor cells by responding to signals in the tumor microenvironment, and they can also inhibit immune checkpoints to relieve adaptive immune resistance. The strategies mentioned in this article provide potential solutions for the clinical therapy of immune-resistant cancer.
ACCOUNTS OF MATERIALS RESEARCH
(2022)