Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use

DNA Methylation, Its Mediators and Genome Integrity

(2015) Huan Meng et al.   International Journal of Biological Sciences

Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism

(2015) Seung Min Jeong et al.   MOLECULES AND CELLS

Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine

(2015) Silvia Sookoian et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process

(2014) Antero Salminen et al.   CELLULAR SIGNALLING

Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2

(2014) Peifeng Hou et al.   PLoS One

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases

(2014) Hanna Tarhonskaya et al.   Nature Communications

Simultaneous Quantitation of Alpha-ketoglutaric Acid and 5-Hydroxymethylfurfural in Plasma by HPLC with UV and Fluorescence Detection

(2013) Fabrizio DONNARUMMA et al.   ANALYTICAL SCIENCES

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas

(2013) Luis Jaime Castro-Vega et al.   HUMAN MOLECULAR GENETICS

α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism

(2013) Natsuko Tokonami et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

(2013) J.-A. Losman et al.   SCIENCE

Mutations in the Isocitrate Dehydrogenase Genes IDH1 and IDH2 in Tumors

(2012) Frank G. Schaap et al.   ADVANCES IN ANATOMIC PATHOLOGY

SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors

(2012) Antoine Italiano et al.   BMC CANCER

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

The mitochondrial oxoglutarate carrier: from identification to mechanism

(2012) Magnus Monné et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Anti-osteopenic effect of alpha-ketoglutarate sodium salt in ovariectomized rats

(2012) Radoslaw Piotr Radzki et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

The role of histone demethylases in cancer therapy

(2012) Inga Hoffmann et al.   Molecular Oncology

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

Effects of combined maternal administration with alpha-ketoglutarate (AKG) and β-hydroxy-β-methylbutyrate (HMB) on prenatal programming of skeletal properties in the offspring

(2012) Marcin R Tatara et al.   Nutrition & Metabolism

Metabolomics Approach for Analyzing the Effects of Exercise in Subjects with Type 1 Diabetes Mellitus

(2012) Laura Brugnara et al.   PLoS One

Alpha-ketoglutarate (AKG) inhibits proliferation of colon adenocarcinoma cells in normoxic conditions

(2012) Wojciech Rzeski et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells

(2011) Kang Yao et al.   AMINO ACIDS

Overproduction and secretion of α-ketoglutaric acid by microorganisms

(2011) Christina Otto et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Artefacts in cell culture: α-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media

(2011) Lee Hua Long et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Inhibition of 2-oxoglutarate dependent oxygenases

(2011) Nathan R. Rose et al.   CHEMICAL SOCIETY REVIEWS

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

(2011) M Fernanda Amary et al.   JOURNAL OF PATHOLOGY

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

(2011) D. R. Borger et al.   ONCOLOGIST

Revisiting the TCA cycle: signaling to tumor formation

(2011) Nuno Raimundo et al.   TRENDS IN MOLECULAR MEDICINE

Simultaneous quantitative determination of α-ketoglutaric acid and 5-hydroxymethylfurfural in human plasma by gas chromatography–mass spectrometry

(2010) Bernhard M. Wagner et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Structural studies on human 2-oxoglutarate dependent oxygenases

(2010) Michael A McDonough et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Alpha-Ketoglutarate and intestinal function

(2010) Yongqing Hou   Frontiers in Bioscience-Landmark

SDHA is a tumor suppressor gene causing paraganglioma

(2010) Nelly Burnichon et al.   HUMAN MOLECULAR GENETICS

Treatment with growth hormone and IGF-I in growing rats increases bone mineral content but not bone mineral density

(2010) Harold N. Rosen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

(2010) K. A. Janeway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IDH mutations in glioma and acute myeloid leukemia

(2010) Lenny Dang et al.   TRENDS IN MOLECULAR MEDICINE

Effects of α-ketoglutarate on neutrophil intracellular amino and α-keto acid profiles and ROS production

(2009) Jörg Mühling et al.   AMINO ACIDS

Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model

(2009) Ken Matsumoto et al.   CANCER SCIENCE

Acute toxicity of some synthetic cyanogens in rats and their response to oral treatment with alpha-ketoglutarate

(2009) R. Bhattacharya et al.   FOOD AND CHEMICAL TOXICOLOGY

The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications

(2009) C. A. Stratakis et al.   JOURNAL OF INTERNAL MEDICINE

Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells

(2009) Ana M Cervera et al.   Molecular Cancer

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Functions and Regulatory Mechanisms of Gq-Signaling Pathways

(2009) Norikazu Mizuno et al.   NEUROSIGNALS

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death

(2009) D A Tennant et al.   ONCOGENE

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Growth Hormone, Insulin-Like Growth Factors, and the Skeleton

(2008) Andrea Giustina et al.   ENDOCRINE REVIEWS

Germline SDHB Mutations and Familial Renal Cell Carcinoma

(2008) C. Ricketts et al.   JNCI-Journal of the National Cancer Institute

Poly(triol α-ketoglutarate) as Biodegradable, Chemoselective, and Mechanically Tunable Elastomers

(2008) Devin G. Barrett et al.   MACROMOLECULES

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Expanding chemical biology of 2-oxoglutarate oxygenases

(2008) Christoph Loenarz et al.   Nature Chemical Biology

Dietary α-ketoglutarate reduces gastrectomy-evoked loss of calvaria and trabecular bone in female rats

(2008) Piotr J. Dobrowolski et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Oxidative stress mediated cytotoxicity of cyanide in LLC-MK2 cells and its attenuation by alpha-ketoglutarate and N-acetyl cysteine

(2008) J. Hariharakrishnan et al.   TOXICOLOGY LETTERS

Cell cycle control as a basis for cancer chemoprevention through dietary agents

(2007) Syed Musthapa Meeran   Frontiers in Bioscience-Landmark

The absorption, tissue distribution and excretion of enteraly administered α-ketoglutarate in rats

(2007) R. Filip et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION