标题
The role of histone demethylases in cancer therapy
作者
关键词
-
出版物
Molecular Oncology
Volume 6, Issue 6, Pages 683-703
出版商
Wiley
发表日期
2012-08-07
DOI
10.1016/j.molonc.2012.07.004
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Lysine-Specific Histone Demethylase 1 Inhibitors Control Breast Cancer Proliferation in ERα-Dependent and -Independent Manners
- (2012) Julie A. Pollock et al. ACS Chemical Biology
- Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases
- (2012) Esther C. Y. Woon et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Histone demethylase JMJD5 is essential for embryonic development
- (2012) Sangphil Oh et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
- (2012) William J. Harris et al. CANCER CELL
- Identification of catechols as histone-lysine demethylase inhibitors
- (2012) Anders L. Nielsen et al. FEBS LETTERS
- Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor
- (2012) Dominica Willmann et al. INTERNATIONAL JOURNAL OF CANCER
- TSA-induced JMJD2B downregulation is associated with cyclin B1-dependent survivin degradation and apoptosis in LNCap cells
- (2012) Shan Zhu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases
- (2012) Nathan R. Rose et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
- (2012) Tino Schenk et al. NATURE MEDICINE
- Epigenetic protein families: a new frontier for drug discovery
- (2012) Cheryl H. Arrowsmith et al. NATURE REVIEWS DRUG DISCOVERY
- Molecular mechanisms and potential functions of histone demethylases
- (2012) Susanne Marije Kooistra et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Regulation of Tumor Suppressor p53 and HCT116 Cell Physiology by Histone Demethylase JMJD2D/KDM4D
- (2012) Tae-Dong Kim et al. PLoS One
- Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors
- (2011) Brian Lohse et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer
- (2011) Wenjuan Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors
- (2011) Hanae Benelkebir et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Inhibitors of histone demethylases
- (2011) Brian Lohse et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties
- (2011) J. Wang et al. CANCER RESEARCH
- A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases
- (2011) Dante Rotili et al. CHEMISTRY & BIOLOGY
- Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds
- (2011) Kai-Hsuan Chang et al. ChemMedChem
- Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A
- (2011) T. Sengoku et al. GENES & DEVELOPMENT
- Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors
- (2011) Hans-Ulrich Schildhaus et al. HUMAN PATHOLOGY
- Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family
- (2011) Lars Hillringhaus et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Jumonji/ARID1 B (JARID1B) Protein Promotes Breast Tumor Cell Cycle Progression through Epigenetic Repression of MicroRNA let-7e
- (2011) Doyel Mitra et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro
- (2011) Bei-Xu Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Lysine Demethylases Inhibitors
- (2011) Takayoshi Suzuki et al. JOURNAL OF MEDICINAL CHEMISTRY
- An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases
- (2011) Anup K. Upadhyay et al. JOURNAL OF MOLECULAR BIOLOGY
- A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases
- (2011) Xuelai Luo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Histone Demethylase JMJD2A Regulates Kaposi's Sarcoma-Associated Herpesvirus Replication and Is Targeted by a Viral Transcriptional Factor
- (2011) P.-C. Chang et al. JOURNAL OF VIROLOGY
- Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer
- (2011) Eric C. Kauffman et al. MOLECULAR CARCINOGENESIS
- LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
- (2011) Antonio Adamo et al. NATURE CELL BIOLOGY
- The Expression of Histone Demethylase JMJD1A in Renal Cell Carcinoma
- (2011) X. GUO et al. NEOPLASMA
- The H3K27me3 demethylase, KDM6B, is induced by Epstein–Barr virus and over-expressed in Hodgkin's Lymphoma
- (2011) J A Anderton et al. ONCOGENE
- Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development
- (2011) Masahito Kawazu et al. PLoS One
- Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1-CoREST Complex
- (2011) Riccardo Baron et al. STRUCTURE
- Histone modification: cause or cog?
- (2011) Steven Henikoff et al. TRENDS IN GENETICS
- Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases
- (2010) Nima Mosammaparast et al. Annual Review of Biochemistry
- Structurally Designedtrans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1,,§
- (2010) Shinya Mimasu et al. BIOCHEMISTRY
- A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
- (2010) Sreenath V. Sharma et al. CELL
- Tumor suppression by the histone demethylase UTX
- (2010) Miao-Chih Tsai et al. CELL CYCLE
- Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
- (2010) Martin Sauvageau et al. Cell Stem Cell
- Jumonji Domain Containing 1A Is a Novel Prognostic Marker for Colorectal Cancer: In vivo Identification from Hypoxic Tumor Cells
- (2010) M. Uemura et al. CLINICAL CANCER RESEARCH
- Structural insights into histone lysine demethylation
- (2010) Haifeng Hou et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Histone Demethylase JmjD2A Regulates Neural Crest Specification
- (2010) Pablo Hernan Strobl-Mazzulla et al. DEVELOPMENTAL CELL
- LSD1 demethylates histone and non-histone proteins
- (2010) Thomas B. Nicholson et al. Epigenetics
- Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
- (2010) Shinya Hayami et al. INTERNATIONAL JOURNAL OF CANCER
- Key roles of histone methyltransferase and demethylase in leukemogenesis
- (2010) Akihide Yoshimi et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches
- (2010) Nathan R. Rose et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors
- (2010) Shohei Hamada et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural Basis for Human PHF2 Jumonji Domain Interaction with Metal Ions
- (2010) John R. Horton et al. JOURNAL OF MOLECULAR BIOLOGY
- Histone methyltransferases: regulation of transcription and contribution to human disease
- (2010) Keisuke Nimura et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2
- (2010) Claudia Binda et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4
- (2010) Eric Metzger et al. NATURE
- Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates
- (2010) Armin Thalhammer et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors
- (2010) Oliver N. F. King et al. PLoS One
- Targeting epigenetic modifiers: Inhibitors of histone methyltransferases
- (2010) Elisabeth-Maria Bissinger et al. MedChemComm
- Role of Hypoxia-Inducible Factors in Epigenetic Regulation via Histone Demethylases
- (2009) Jun Yang et al. Annals of the New York Academy of Sciences
- Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors
- (2009) Shohei Hamada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy
- (2009) J. H. Schulte et al. CANCER RESEARCH
- Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
- (2009) Soyoung Lim et al. CARCINOGENESIS
- Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)
- (2009) Rok Sekirnik et al. CHEMICAL COMMUNICATIONS
- The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors
- (2009) Astrid Spannhoff et al. ChemMedChem
- Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes
- (2009) Y. Huang et al. CLINICAL CANCER RESEARCH
- Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail
- (2009) D. Brasacchio et al. DIABETES
- New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin
- (2009) Federico Forneris et al. FEBS Journal
- Nickel Ions Inhibit Histone Demethylase JMJD1A and DNA Repair Enzyme ABH2 by Replacing the Ferrous Iron in the Catalytic Centers
- (2009) Haobin Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Novel Mammalian Flavin-dependent Histone Demethylase
- (2009) Aristotele Karytinos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors
- (2009) Rie Ueda et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A miniaturized screen for inhibitors of Jumonji histone demethylases
- (2009) Masaaki Sakurai et al. Molecular BioSystems
- Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases
- (2009) John R Horton et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
- (2009) G Liu et al. ONCOGENE
- Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing
- (2009) Celia J. Webby et al. SCIENCE
- Histone methyltransferases in cancer
- (2009) Mareike Albert et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Mucosa-Associated Lymphoid Tissue Lymphoma: Novel Translocations Including Rearrangements of ODZ2, JMJD2C, and CNN3
- (2008) U. Vinatzer et al. CLINICAL CANCER RESEARCH
- The emerging functions of histone demethylases
- (2008) Karl Agger et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Cancer treatment of the future: Inhibitors of histone methyltransferases
- (2008) Astrid Spannhoff et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Characterization of Recombinant Human Prolyl 3-Hydroxylase Isoenzyme 2, an Enzyme Modifying the Basement Membrane Collagen IV
- (2008) Päivi Tiainen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases⊥
- (2008) Nathan R. Rose et al. JOURNAL OF MEDICINAL CHEMISTRY
- Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules
- (2008) Q. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25Å
- (2007) Shinya Mimasu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Polycythemia vera transforming to acute myeloid leukemia and complex abnormalities including 9p homogeneously staining region with amplification of MLLT3, JMJD2C, JAK2, and SMARCA2
- (2007) Catherine Hélias et al. CANCER GENETICS AND CYTOGENETICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now