标题
The chemistry of senescence
作者
关键词
-
出版物
Nature Reviews Chemistry
Volume 3, Issue 7, Pages 426-441
出版商
Springer Science and Business Media LLC
发表日期
2019-06-13
DOI
10.1038/s41570-019-0108-0
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
- (2019) Jamie N. Justice et al. EBioMedicine
- The curcumin analog EF24 is a novel senolytic agent
- (2019) Wen Li et al. Aging-US
- Oxidation resistance 1 is a novel senolytic target
- (2018) Xin Zhang et al. AGING CELL
- Senescence mirrors the extent of liver fibrosis in chronic hepatitis C virus infection
- (2018) F. Wandrer et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction?
- (2018) Zakia Sultana et al. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
- (2018) Xingui Liu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A versatile drug delivery system targeting senescent cells
- (2018) Daniel Muñoz‐Espín et al. EMBO Molecular Medicine
- Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis
- (2018) Sundeep Khosla et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
- (2018) Darren J. Baker et al. JOURNAL OF CLINICAL INVESTIGATION
- Is DNA damage indispensable for stress-induced senescence?
- (2018) Anna Bielak-Zmijewska et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Senolytics improve physical function and increase lifespan in old age
- (2018) Ming Xu et al. NATURE MEDICINE
- Senotherapeutics for healthy ageing
- (2018) Laura J. Niedernhofer et al. NATURE REVIEWS DRUG DISCOVERY
- Evidence of oxidative stress-induced senescence in mature, post-mature and pathological human placentas
- (2018) Tereza Cindrova-Davies et al. PLACENTA
- Hallmarks of Cellular Senescence
- (2018) Alejandra Hernandez-Segura et al. TRENDS IN CELL BIOLOGY
- Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
- (2018) Tyler J. Bussian et al. NATURE
- Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts
- (2018) Bela Ozsvari et al. Aging-US
- The emerging field of senotherapeutic drugs
- (2018) Vassilios Myrianthopoulos Future Medicinal Chemistry
- Bioactivities of EF24, a Novel Curcumin Analog: A Review
- (2018) Yonghan He et al. Frontiers in Oncology
- The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
- (2017) Birgit Ritschka et al. GENES & DEVELOPMENT
- An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo
- (2017) Beatriz Lozano-Torres et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Clinical Potential of Senolytic Drugs
- (2017) James L. Kirkland et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Cellular senescence: Implications for metabolic disease
- (2017) Marissa J. Schafer et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Senescence-associated reprogramming promotes cancer stemness
- (2017) Maja Milanovic et al. NATURE
- Chemical screening identifies ATM as a target for alleviating senescence
- (2017) Hyun Tae Kang et al. Nature Chemical Biology
- Targeting cellular senescence prevents age-related bone loss in mice
- (2017) Joshua N Farr et al. NATURE MEDICINE
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
- (2017) Ok Hee Jeon et al. NATURE MEDICINE
- The role of cellular senescence in ageing of the placenta
- (2017) Lynne S. Cox et al. PLACENTA
- Identification of HSP90 inhibitors as a novel class of senolytics
- (2017) Heike Fuhrmann-Stroissnigg et al. Nature Communications
- Cellular senescence drives age-dependent hepatic steatosis
- (2017) Mikolaj Ogrodnik et al. Nature Communications
- The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy
- (2017) Markus Schosserer et al. Frontiers in Oncology
- Small molecule compounds that induce cellular senescence
- (2016) Nadezhda V. Petrova et al. AGING CELL
- Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
- (2016) Carolyn M. Roos et al. AGING CELL
- Robust, universal biomarker assay to detect senescent cells in biological specimens
- (2016) Konstantinos Evangelou et al. AGING CELL
- Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
- (2016) Yingying Wang et al. Aging-US
- NKG2D ligands mediate immunosurveillance of senescent cells
- (2016) Adi Sagiv et al. Aging-US
- Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
- (2016) Brandon M. Hall et al. Aging-US
- Morphological and Functional Characteristic of Senescent Cancer Cells
- (2016) Ewa Sikora et al. CURRENT DRUG TARGETS
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
- (2016) Aharon Helman et al. NATURE MEDICINE
- Senescent intimal foam cells are deleterious at all stages of atherosclerosis
- (2016) B. G. Childs et al. SCIENCE
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
- (2016) Reut Yosef et al. Nature Communications
- Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
- (2016) Marco Demaria et al. Cancer Discovery
- Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
- (2016) EA Georgakopoulou et al. Aging-US
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts
- (2015) Hyun Lim et al. BIOCHEMICAL PHARMACOLOGY
- mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
- (2015) Nicolás Herranz et al. NATURE CELL BIOLOGY
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
- (2015) Ming Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Leucocyte telomere length as marker for cardiovascular ageing
- (2014) A. Zietzer et al. Acta Physiologica
- FL118 Induces p53-Dependent Senescence in Colorectal Cancer Cells by Promoting Degradation of MdmX
- (2014) X. Ling et al. CANCER RESEARCH
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Senescence and apoptosis: dueling or complementary cell fates?
- (2014) B. G. Childs et al. EMBO REPORTS
- Cellular senescence: from physiology to pathology
- (2014) Daniel Muñoz-Espín et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
- (2013) David E. Harrison et al. AGING CELL
- Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
- (2013) Christin E. Burd et al. CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Programmed Cell Senescence during Mammalian Embryonic Development
- (2013) Daniel Muñoz-Espín et al. CELL
- Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
- (2013) Mekayla Storer et al. CELL
- α-Fucosidase as a novel convenient biomarker for cellular senescence
- (2013) Dominic Hildebrand et al. CELL CYCLE
- CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversion
- (2013) Olga V. Leontieva et al. CELL CYCLE
- Lysosomal multienzyme complex: pros and cons of working together
- (2013) Erik J. Bonten et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
- (2013) Albert R. Davalos et al. JOURNAL OF CELL BIOLOGY
- Metabolic changes during cellular senescence investigated by proton NMR-spectroscopy
- (2013) Claudia Gey et al. MECHANISMS OF AGEING AND DEVELOPMENT
- A complex secretory program orchestrated by the inflammasome controls paracrine senescence
- (2013) Juan Carlos Acosta et al. NATURE CELL BIOLOGY
- Synthesis of piperlogs and analysis of their effects on cells
- (2013) Zarko V. Boskovic et al. TETRAHEDRON
- The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype
- (2013) Lei Zhao et al. PeerJ
- Glucocorticoids suppress selected components of the senescence-associated secretory phenotype
- (2012) Remi-Martin Laberge et al. AGING CELL
- Targeted Cargo Delivery in Senescent Cells Using Capped Mesoporous Silica Nanoparticles
- (2012) Alessandro Agostini et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity
- (2012) Fong-Chun Huang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
- (2012) Paul D. Ray et al. CELLULAR SIGNALLING
- Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
- (2012) R M Naylor et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- The profile of lysosomal exoglycosidases in replicative and stress-induced senescence in early passage human fibroblasts
- (2012) Małgorzata Knaś et al. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
- Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
- (2012) Xiaoni Kong et al. HEPATOLOGY
- Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
- (2012) Sebastian Müller et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
- (2012) D. J. Adams et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells
- (2011) C. N. Marconett et al. CARCINOGENESIS
- Too many breaks (brakes): Pancreatic β-cell senescence leads to diabetes
- (2011) Omid Tavana et al. CELL CYCLE
- p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
- (2011) Adam Freund et al. EMBO JOURNAL
- Cyclopentenyl Cytosine Induces Senescence in Breast Cancer Cells through the Nucleolar Stress Response and Activation of p53
- (2011) M. Huang et al. MOLECULAR PHARMACOLOGY
- Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- (2011) Tae-Won Kang et al. NATURE
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Telomere dysfunction-induced foci arise with the onset of telomeric deletions and complex chromosomal aberrations in resistant chronic lymphocytic leukemia cells
- (2010) T. Brugat et al. BLOOD
- Cell Senescence in the Aging Kidney
- (2010) H. Yang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Is Telomere Length a Biomarker of Aging? A Review
- (2010) K. A. Mather et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
- (2010) Mariela Jaskelioff et al. NATURE
- Enzyme-Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose
- (2009) Andrea Bernardos et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Real-time in vivo imaging of p16Ink4areveals cross talk with p53
- (2009) Kimi Yamakoshi et al. JOURNAL OF CELL BIOLOGY
- Ceramide Regulates Gemcitabine-Induced Senescence and Apoptosis in Human Pancreatic Cancer Cell Lines
- (2009) D. E. Modrak et al. MOLECULAR CANCER RESEARCH
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- (2009) Francis Rodier et al. NATURE CELL BIOLOGY
- Telomere Diseases
- (2009) Rodrigo T. Calado et al. NEW ENGLAND JOURNAL OF MEDICINE
- Disparate Effects of Roscovitine on Renal Tubular Epithelial Cell Apoptosis and Senescence: Implications for Autosomal Dominant Polycystic Kidney Disease
- (2008) Jin-Young Park et al. AMERICAN JOURNAL OF NEPHROLOGY
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
- Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
- (2008) Juan C. Acosta et al. CELL
- Senescence of Activated Stellate Cells Limits Liver Fibrosis
- (2008) Valery Krizhanovsky et al. CELL
- ATP-Noncompetitive Inhibitors of CDK-Cyclin Complexes
- (2008) Mar Orzáez et al. ChemMedChem
- Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
- (2008) Darren J. Baker et al. NATURE CELL BIOLOGY
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