Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

(2019) Patrick Carlson et al.   NATURE CELL BIOLOGY

A Sox2–Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells

(2019) Giacomo Domenici et al.   ONCOGENE

Revolutionizing Treatment of Advanced Melanoma with Immunotherapy

(2019) Nicole Carreau et al.   SURGICAL ONCOLOGY-OXFORD

ATF4 contributes to autophagy and survival in sunitinib treated brain tumor initiating cells (BTICs)

(2019) Sylvia Moeckel et al.   Oncotarget

Inhibition of BET Proteins and Histone Deacetylase (HDACs): Crossing Roads in Cancer Therapy

(2019) Gloria Manzotti et al.   Cancers

Histone Deacetylase Inhibitors and Phenotypical Transformation of Cancer Cells

(2019) Anna Wawruszak et al.   Cancers

ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield

(2019) Juanjuan Ou et al.   Nature Communications

ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness”

(2019) Patricia Dauer et al.   Cell Death & Disease

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

(2019) Maartje van der Heijden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer

(2019) Helai P. Mohammad et al.   NATURE MEDICINE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

Immunotherapy and targeted therapy combinations in metastatic breast cancer

(2019) Francisco J Esteva et al.   LANCET ONCOLOGY

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

(2019) Tareq Saleh et al.   CANCER RESEARCH

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

(2019) Jonathan Cooper et al.   CANCER CELL

The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance

(2019) Xing Huang et al.   Autophagy

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

(2019) Mohamed Elgendy et al.   CANCER CELL

Can Exercise-Induced Modulation of the Tumor Physiologic Microenvironment Improve Antitumor Immunity?

(2019) Xiaojie Zhang et al.   CANCER RESEARCH

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma

(2019) Nikki K. Lytle et al.   CELL

Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells

(2019) Yuxuan Miao et al.   CELL

Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance

(2019) Shun Li et al.   Nature Communications

STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cells

(2018) Yuying Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Itraconazole targets cell cycle heterogeneity in colorectal cancer

(2018) Simon J.A. Buczacki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-γ orchestrates tumor elimination, tumor dormancy, tumor escape, and progression

(2018) Hussein F. Aqbi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B

(2018) Mikkel Staberg et al.   Molecular Oncology

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

(2018) Wei Yan et al.   NATURE CELL BIOLOGY

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

(2018) Nikolaos Zacharakis et al.   NATURE MEDICINE

Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

(2018) Arnaud Pommier et al.   SCIENCE

Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma

(2018) Melanie Werner-Klein et al.   Nature Communications

Rethinking Extended Adjuvant Antiestrogen Therapy to Increase Survivorship in Breast Cancer

(2018) Balkees Abderrahman et al.   JAMA Oncology

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

(2018) Tareq Saleh et al.   Frontiers in Oncology

Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy

(2018) Yuzhu Hou et al.   IMMUNITY

TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence

(2018) Isabel Puig et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

(2018) Benjamin D. Hopkins et al.   NATURE

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

(2018) Francesca Zanconato et al.   NATURE MEDICINE

The role of cancer stem cells in the modulation of anti-tumor immune responses”

(2018) Cristina Maccalli et al.   SEMINARS IN CANCER BIOLOGY

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

(2018) Tyler Risom et al.   Nature Communications

Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance

(2018) Megha Budhwani et al.   Frontiers in Oncology

Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer

(2018) François M. Vallette et al.   BIOCHEMICAL PHARMACOLOGY

Cancer stem cells: Road to therapeutic resistance and strategies to overcome resistance

(2018) Monish Ram Makena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance

(2018) Emma Madden et al.   BIOLOGY OF THE CELL

SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance

(2018) Xiaodong Yuan et al.   BRITISH JOURNAL OF CANCER

Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling

(2018) Amanda Balboni Iniguez et al.   CANCER CELL

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

(2018) Kunihiko Hinohara et al.   CANCER CELL

STING promotes homeostasis via regulation of cell proliferation and chromosomal stability

(2018) Diana Rose E. Ranoa et al.   CANCER RESEARCH

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Dormant tumour cells, their niches and the influence of immunity

(2018) Erica T. Goddard et al.   NATURE CELL BIOLOGY

Unbalanced YAP–SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma

(2018) Lianghai Wang et al.   ONCOGENE

Therapy-induced enrichment of cancer stem-like cells in solid human tumors: Where do we stand?

(2018) Sara R. Martins-Neves et al.   PHARMACOLOGICAL RESEARCH

Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

(2018) Sébastien Corre et al.   Nature Communications

ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma

(2018) Rani Ojha et al.   Cancer Discovery

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

(2018) Shunsuke Kitajima et al.   Cancer Discovery

Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer

(2017) Klara M. Giessler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

CDK4/6 inhibition triggers anti-tumour immunity

(2017) Shom Goel et al.   NATURE

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

(2017) Xiaoyang Lan et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

(2017) Georg Fluegen et al.   NATURE CELL BIOLOGY

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

(2017) Elodie M Kuntz et al.   NATURE MEDICINE

Marked for death: targeting epigenetic changes in cancer

(2017) Sophia Xiao Pfister et al.   NATURE REVIEWS DRUG DISCOVERY

Transcriptional reprogramming in cellular quiescence

(2017) Benjamin Roche et al.   RNA Biology

Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

(2017) Sanja Stevanović et al.   SCIENCE

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells

(2017) Yuying Liu et al.   Nature Communications

Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers

(2017) Nirakar Rajbhandari et al.   Cell Reports

Chemotherapy-Induced Ca 2+ Release Stimulates Breast Cancer Stem Cell Enrichment

(2017) Haiquan Lu et al.   Cell Reports

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors

(2017) Maithili P. Dalvi et al.   Cell Reports

Hexokinase 2 is a determinant of neuroblastoma metastasis

(2016) Liat Edry Botzer et al.   BRITISH JOURNAL OF CANCER

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy

(2016) Xiaohong Wang et al.   CANCER RESEARCH

miR-155 Drives Metabolic Reprogramming of ER + Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors

(2016) Marina Bacci et al.   CANCER RESEARCH

Inflammation Triggers Zeb1-Dependent Escape from Tumor Latency

(2016) Jasmine M. De Cock et al.   CANCER RESEARCH

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer

(2016) D S Matassa et al.   CELL DEATH AND DIFFERENTIATION

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

(2016) Aldwin Suryo Rahmanto et al.   EMBO JOURNAL

Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells

(2016) Kyle K. Payne et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma

(2016) J. B. Gifford et al.   MOLECULAR CANCER THERAPEUTICS

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

(2016) Maia Vinogradova et al.   Nature Chemical Biology

Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape

(2016) Malte Mohme et al.   Nature Reviews Clinical Oncology

Treating cancer with selective CDK4/6 inhibitors

(2016) Ben O'Leary et al.   Nature Reviews Clinical Oncology

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

(2016) Eric Tran et al.   NEW ENGLAND JOURNAL OF MEDICINE

The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations

(2016) H Endo et al.   ONCOGENE

Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer

(2016) Pasquale Sansone et al.   Nature Communications

Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

(2016) Michael Ramirez et al.   Nature Communications

Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells

(2016) Luigi Ippolito et al.   Oncotarget

Dynamic regulation of the cancer stem cell compartment by Cripto-1 in colorectal cancer

(2015) F Francescangeli et al.   CELL DEATH AND DIFFERENTIATION

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

(2015) Hyo-eun C Bhang et al.   NATURE MEDICINE

Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1

(2015) Tina El Rayes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity of somatic mutations in human gastrointestinal cancers

(2015) E. Tran et al.   SCIENCE

Interplay between unfolded protein response and autophagy promotes tumor drug resistance

(2015) MING-MING YAN et al.   Oncology Letters

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

(2015) Maria Soledad Sosa et al.   Nature Communications

Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread

(2015) Elisa Giannoni et al.   Oncotarget

Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis

(2015) Cory D. Bovenzi et al.   Biomed Research International

Abstract 4782: Epigenetic resistance to Notch inhibition in T cell acute lymphoblastic leukemia

(2015) Birgit Knoechel et al.   CANCER RESEARCH

Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome

(2014) J. Doyen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

(2014) Robert J. Vanner et al.   CANCER CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1and Cyclin D1 and induces cell cycle exit and neuronal differentiation

(2014) Ulf Soppa et al.   CELL CYCLE

Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer

(2014) A Zeuner et al.   CELL DEATH AND DIFFERENTIATION

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

Colorectal Cancer Stem Cells: From the Crypt to the Clinic

(2014) Ann Zeuner et al.   Cell Stem Cell

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic Cancer

(2013) W.-c. Lin et al.   CANCER RESEARCH

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition

(2013) Daniel J. Goff et al.   Cell Stem Cell

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Reduction of Breast Cancer Relapses with Perioperative Non-Steroidal Anti-Inflammatory Drugs: New Findings and a Review

(2013) Michael Retsky et al.   CURRENT MEDICINAL CHEMISTRY

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells

(2013) Lara H. El Touny et al.   JOURNAL OF CLINICAL INVESTIGATION

Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle

(2013) Jia-Yun Chen et al.   MOLECULAR CELL

Metastasis Awakening: The challenges of targeting minimal residual cancer

(2013) Bernhard Polzer et al.   NATURE MEDICINE

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

(2013) Felipe De Sousa E Melo et al.   NATURE MEDICINE

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Analysis of Marker-Defined HNSCC Subpopulations Reveals a Dynamic Regulation of Tumor Initiating Properties

(2012) Paloma Bragado et al.   PLoS One

Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

(2011) Y. Zhou et al.   CANCER RESEARCH

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC

(2010) Alexa B. Turke et al.   CANCER CELL

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Targeting leukemic stem cells by breaking their dormancy

(2010) Marieke Alida Gertruda Essers et al.   Molecular Oncology

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

(2010) Boyi Gan et al.   NATURE

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells

(2010) M-Q Gao et al.   ONCOGENE

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)

(2010) A. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma

(2009) Jennifer L. Dembinski et al.   CLINICAL & EXPERIMENTAL METASTASIS

Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies

(2009) Annamaria Rapisarda et al.   DRUG RESISTANCE UPDATES

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells

(2008) Zhen Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

(2008) Wataru Sakai et al.   NATURE

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS