Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

Pathophysiological significance of c-junN-terminal kinase in acetaminophen hepatotoxicity

(2015) Kuo Du et al.   Expert Opinion on Drug Metabolism & Toxicology

Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses

(2015) Kuo Du et al.   FOOD AND CHEMICAL TOXICOLOGY

A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine andN-ethylmaleimide

(2015) Mitchell R. Mcgill et al.   TOXICOLOGY MECHANISMS AND METHODS

Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells

(2015) Yuchao Xie et al.   XENOBIOTICA

A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine andN-ethylmaleimide

(2015) Mitchell R. Mcgill et al.   TOXICOLOGY MECHANISMS AND METHODS

Targeting Mitochondria-Derived Reactive Oxygen Species to Reduce Epithelial Barrier Dysfunction and Colitis

(2014) Arthur Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

(2014) Mitchell R McGill et al.   Expert Opinion on Drug Metabolism & Toxicology

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase

(2014) Kuo Du et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

(2014) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury

(2012) Hong-Min Ni et al.   TOXICOLOGICAL SCIENCES

Emergency Department Visits for Overdoses of Acetaminophen-Containing Products

(2011) Daniel S. Budnitz et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Lipopolysaccharide-Induced Mitochondrial DNA Depletion

(2011) Amal Choumar et al.   ANTIOXIDANTS & REDOX SIGNALING

Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition

(2011) Amanda LoGuidice et al.   HEPATOLOGY

Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States

(2011) Angelika D. Manthripragada et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity

(2011) Mary Lynn Bajt et al.   TOXICOLOGICAL SCIENCES

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity

(2011) Anup Ramachandran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

(2010) Anup Ramachandran et al.   FREE RADICAL RESEARCH

Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase

(2010) R. Agarwal et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Oxygen Tension Modulates Acetaminophen-Induced Mitochondrial Oxidant Stress and Cell Injury in Cultured Hepatocytes

(2010) Hui-Min Yan et al.   TOXICOLOGICAL SCIENCES

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

Sensitivity of Liver Injury in Heterozygous Sod2 Knockout Mice Treated with Troglitazone or Acetaminophen

(2009) Kazunori Fujimoto et al.   TOXICOLOGIC PATHOLOGY

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

(2008) Jan Trnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY