PIEZO1 Is Selectively Expressed in Small Diameter Mouse DRG Neurons Distinct From Neurons Strongly Expressing TRPV1

Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice

(2019) Mingmin Zhang et al.   Cell Reports

Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?

(2019) Nikita Mikhailov et al.   NEUROPHARMACOLOGY

Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation

(2018) Nathaniel G. dela Paz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

(2018) Shang Ma et al.   CELL

Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1

(2018) Jerome J. Lacroix et al.   Nature Communications

A TRP channel trio mediates acute noxious heat sensing

(2018) Ine Vandewauw et al.   NATURE

Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells

(2018) Josefina Inés del Mármol et al.   eLife

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

(2018) Wei-Zheng Zeng et al.   SCIENCE

PIEZO2 mediates injury-induced tactile pain in mice and humans

(2018) Marcin Szczot et al.   Science Translational Medicine

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

(2018) Swetha E. Murthy et al.   Science Translational Medicine

Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination

(2017) Alice Arcourt et al.   NEURON

Gap junctions, pannexins and pain

(2017) David C. Spray et al.   NEUROSCIENCE LETTERS

Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers

(2017) Hélène Beaudry et al.   PAIN

Biallelic Loss of Proprioception-Related PIEZO2 Causes Muscular Atrophy with Perinatal Respiratory Distress, Arthrogryposis, and Scoliosis

(2016) Andrea Delle Vedove et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss of the proprioception and touch sensation channel PIEZO2 in siblings with a progressive form of contractures

(2016) A.A. Mahmud et al.   CLINICAL GENETICS

Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain

(2016) Yu Shin Kim et al.   NEURON

The potential role of Piezo2 in the mediation of visceral sensation

(2016) Jing Yang et al.   NEUROSCIENCE LETTERS

The Role of PIEZO2 in Human Mechanosensation

(2016) Alexander T. Chesler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1

(2016) Pooja Singhmar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons

(2016) Danny Florez-Paz et al.   Scientific Reports

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

(2015) Istvan Borbiro et al.   Science Signaling

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

(2015) Viktor Lukacs et al.   Nature Communications

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

(2015) Istvan Borbiro et al.   Science Signaling

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The functional and anatomical dissection of somatosensory subpopulations using mouse genetics

(2014) Claire E. Le Pichon et al.   Frontiers in Neuroanatomy

Human PIEZO1: Removing Inactivation

(2013) Chilman Bae et al.   BIOPHYSICAL JOURNAL

The Star-Nosed Mole Reveals Clues to the Molecular Basis of Mammalian Touch

(2013) Kristin A. Gerhold et al.   PLoS One

A role for Piezo2 in EPAC1-dependent mechanical allodynia

(2013) N Eijkelkamp et al.   Nature Communications

Mechanosensitive Ca2+permeant cation channels in human prostate tumor cells

(2012) Rosario Maroto et al.   Channels

Single Mechanosensitive and Ca2+-Sensitive Channel Currents Recorded from Mouse and Human Embryonic Stem Cells

(2012) Bernat Soria et al.   JOURNAL OF MEMBRANE BIOLOGY

The role of Drosophila Piezo in mechanical nociception

(2012) Sung Eun Kim et al.   NATURE

Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents

(2012) Adrienne E. Dubin et al.   Cell Reports

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Analysis of hyperalgesia time courses in humans after painful electrical high-frequency stimulation identifies a possible transition from early to late LTP-like pain plasticity

(2011) Doreen B. Pfau et al.   PAIN

Nociceptors: the sensors of the pain pathway

(2010) Adrienne E. Dubin et al.   JOURNAL OF CLINICAL INVESTIGATION

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Persistent Pain Is Dependent on Spinal Mitochondrial Antioxidant Levels

(2009) E. S. Schwartz et al.   JOURNAL OF NEUROSCIENCE

Models and Mechanisms of Hyperalgesia and Allodynia

(2009) Jürgen Sandkühler   PHYSIOLOGICAL REVIEWS

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice

(2008) Erica S. Schwartz et al.   PAIN

Trpv1 mediates spontaneous firing and heat sensitization of cutaneous primary afferents after plantar incision

(2008) Ratan K. Banik et al.   PAIN